[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100453964":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":20,"locations":29,"responsibleParty":59,"collaborators":7,"id":62,"slug":7,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":76,"studyType":77,"phases":7,"briefSummary":78,"conditions":79,"keywords":84,"overallStatus":32,"whyStopped":7,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Ulm","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"BIOLOGICAL","Application of exosomes in a whole blood assay","Co-incubation of patient-derived whole blood samples with mesenchymal stem cell derived exosomes and read-out of biomarkers, RNA and immune phenotypes after 24h.",[14,18],{"name":15,"affiliation":16,"role":17},"Manfred Weiss, MD","Clinic of Anaesthesiology and Intensive Care Medicine","PRINCIPAL_INVESTIGATOR",{"name":19,"affiliation":16,"role":17},"Marion Schneider, PhD",[21,26],{"name":15,"role":22,"phone":23,"phoneExt":24,"email":25},"CONTACT","+49(0)731500","60226","manfred.weiss@uniklinik-ulm.de",{"name":19,"role":22,"phone":23,"phoneExt":27,"email":28},"60319","marion.schneider@uni-ulm.de",[30],{"facility":31,"status":32,"city":33,"state":7,"zip":34,"country":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Ulm University Hospital, Clinic of Anesthesiology and Intensive Care Medicine","RECRUITING","Ulm","89070","Germany",{"type":37,"coordinates":38},"Point",[39,40],9.99155,48.39841,{"lat":40,"lon":39},[43,46,48,49,50,53,55,57],{"name":44,"role":22,"phone":45,"phoneExt":7,"email":25},"Manfred Weiss, MD, MBA","+49-(0)731-500-60226",{"name":19,"role":22,"phone":47,"phoneExt":7,"email":28},"+49-(0)731-500-60080",{"name":15,"role":17,"phone":7,"phoneExt":7,"email":7},{"name":19,"role":17,"phone":7,"phoneExt":7,"email":7},{"name":51,"role":52,"phone":7,"phoneExt":7,"email":7},"Bettina Jungwirth, MD","SUB_INVESTIGATOR",{"name":54,"role":52,"phone":7,"phoneExt":7,"email":7},"Karl Traeger, MD",{"name":56,"role":52,"phone":7,"phoneExt":7,"email":7},"Eberhard Barth, MD",{"name":58,"role":17,"phone":7,"phoneExt":7,"email":7},"Benedikt Nussbaum, MD",{"type":17,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Manfred Weiss","Professor, MD, MBA, Clinical Professor","100453964",false,"NCT05191381","Immune Modulation by Exosomes in COVID-19","Immune Modulation by Stem Cell Derived Exosomes in Critically Ill COVID-19","IMECOV19","Inclusion Criteria:\n\n* Critically ill COVID-19 patients with lung dysfunction\n* COVID-19 WHO severity degree \\>= 4, ARDS (WHO Definition 13 March 2020)\n* Body weight \\> 50 kg\n* Informed consent\n\nExclusion Criteria:\n\n* Pregnant or breast feeding women",true,"ALL","18 Years","90 Years",{"count":74,"type":75},40,"ESTIMATED","12 Months","OBSERVATIONAL","Following whole blood stimulation with mesenchymal stem cell derived exosomes, immune phenotype, cytokine release and mRNA expression patterns from critically ill patients with COVID-19 will be determined.",[80,81,82,83],"COVID-19","Critical Illness","Hypercytokinemia","Lung Fibrosis",[80,85,82,86,87,88,89,90],"Critical illness","Exosomes","Mesenchymal stem cells","Tissue reconstitution","Immune modulation","Sepsis","2024-01-16",{"date":93,"type":94},"2024-01-17","ACTUAL",{"date":96,"type":94},"2021-12-22",{"date":98,"type":75},"2026-12-31",{"name":5,"class":6},1]