[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621128":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":25,"studyPopulation":26,"armGroups":22,"interventions":27,"overallOfficials":22,"centralContacts":32,"locations":40,"responsibleParty":64,"collaborators":22,"id":67,"slug":22,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":22,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":22,"studyType":79,"phases":22,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":43,"whyStopped":22,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Badr University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":22,"otherOutcomes":22},[9,13,16,19],{"measure":10,"description":11,"timeFrame":12},"serum IgG, IgA, IgM","Immunoglobulins: Concentrations of IgG(mg\u002Fdl) IgA,(mg\u002Fdl) and IgM (mg\u002Fdl) were determined from serum using an automated nephelometer","Upon enrollment and prior to any intervention baseline data were collected",{"measure":14,"description":15,"timeFrame":12},"Respiratory Rate","Respiratory rate (breaths\u002Fminute) was determined by direct observation and counting of chest wall movements over one full minute",{"measure":17,"description":18,"timeFrame":12},"Arterial Oxygen Saturation (SaO2)","Peripheral oxygen saturation (%) was measured non-invasively via pulse oximetry",{"measure":20,"description":21,"timeFrame":12},"White Blood Cell count","Total WBC count (thousands\u002Fmm³) was measured from a whole blood sample using an ADVIA 120 automated hematology analyzer",null,{"allocation":22,"interventionModel":22,"interventionModelDescription":22,"primaryPurpose":22,"observationalModel":6,"timePerspective":24,"maskingInfo":22},"RETROSPECTIVE","descriptive, cross-sectional study analyzed baseline data from 40 children with DS and acute pneumonia enrolled prior to intervention in a larger trial. Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.","Data collection occurred at the inpatient pediatric ward of King Abdulaziz University Hospital.",[28],{"type":29,"name":30,"description":31,"armGroupLabels":22,"otherNames":22},"PROCEDURE","Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age","Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":22,"email":37},"Mona Mohamed Abdelkhalek, assistance prof","CONTACT","002021024056108","3m.sons@gmail.com",{"name":34,"role":35,"phone":36,"phoneExt":22,"email":39},"Mona.Abdelkhalek@buc.edu.eg",[41,56],{"facility":42,"status":43,"city":44,"state":22,"zip":22,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Badr university","RECRUITING","Cairo","Egypt","EG",{"type":48,"coordinates":49},"Point",[50,51],31.24967,30.06263,{"lat":51,"lon":50},[54],{"name":55,"role":35,"phone":22,"phoneExt":22,"email":22},"Mona Abdelkhalek, Phd",{"facility":57,"status":43,"city":44,"state":22,"zip":22,"country":45,"countryCode":46,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"Mona Mohamed Abdelkhalek",{"type":48,"coordinates":59},[50,51],{"lat":51,"lon":50},[62],{"name":63,"role":35,"phone":36,"phoneExt":22,"email":37},"Mona Abdelkhalek, assistance prof",{"type":65,"investigatorFullName":57,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","assistance professor","100621128",false,"NCT07366593","Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis","Relationship Between Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis","Inclusion Criteria:\n\n* Down Syndrome with acute bronchopneumonia\n* sufficient cognitive ability\n\nExclusion Criteria:\n\n* severe congenital heart defects\n* primary immunodeficiencies","ALL","1 Year","6 Years",{"count":77,"type":78},40,"ESTIMATED","OBSERVATIONAL","Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age",[82],"Down Syndrome",[84],"Down Syndrome, pneumonia, immune, oxygen saturation","2026-01-16",{"date":87,"type":88},"2026-01-26","ACTUAL",{"date":90,"type":88},"2025-07-01",{"date":92,"type":78},"2026-01-30",{"name":5,"class":6},2]