[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637721":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":59,"collaborators":62,"id":95,"slug":11,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":96,"sex":102,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":11,"studyType":108,"phases":109,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":118,"whyStopped":11,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"Changhai Hospital","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Acetic Acid-Indigo Carmine Chromocolonoscopy Group","EXPERIMENTAL",null,[13],"Procedure: Acetic Acid-Indigo Carmine Chromocolonoscopy Group",{"label":15,"type":16,"description":11,"interventionNames":17},"Brilliant Blue Chromocolonoscopy Sham-Control Group","SHAM_COMPARATOR",[18],"Procedure: Brilliant Blue Chromocolonoscopy Sham-Control Group",{"label":20,"type":21,"description":11,"interventionNames":11},"Conventional White-Light Colonoscopy Group","NO_INTERVENTION",[23,27],{"type":24,"name":9,"description":25,"armGroupLabels":26,"otherNames":11},"PROCEDURE","Participants undergo colonoscopy with acetic acid-indigo carmine chromoendoscopy. After successful cecal intubation and randomization, the colonoscope is withdrawn and a spray catheter is used to apply an opaque acetic acid-indigo carmine solution from the cecum to the splenic flexure.",[9],{"type":24,"name":15,"description":28,"armGroupLabels":29,"otherNames":11},"Participants undergo colonoscopy with brilliant blue dye application as a sham chromoendoscopy control to maintain participant blinding. After cecal intubation and randomization, an opaque brilliant blue solution is sprayed from the cecum to the splenic flexure using a spray catheter, with suctioning of any excess dye.",[15],[31],{"name":32,"affiliation":5,"role":33},"Zhaoshen Li, MD","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":11,"email":38},"CONTACT","86-021-31161365","li.zhaoshen@hotmail.com",{"name":40,"role":36,"phone":41,"phoneExt":11,"email":42},"Yu Bai, MD","86-021-31161335","baiyu1998@hotmail.com",[44],{"facility":45,"status":11,"city":46,"state":47,"zip":48,"country":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"China, Shanghai Changhai Hospital, Second Military Medical University","Shanghai","Shanghai Municipality","200433","China",{"type":51,"coordinates":52},"Point",[53,54],121.45806,31.22222,{"lat":54,"lon":53},[57,58],{"name":32,"role":36,"phone":37,"phoneExt":11,"email":38},{"name":40,"role":36,"phone":41,"phoneExt":11,"email":42},{"type":33,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Zhaoshen Li","M.D., Director, Head of Department of Gastroenterology and Digestive Endoscopy Center, Principal Investigator",[63,65,67,70,72,74,76,78,80,83,85,87,89,91,93],{"name":64,"class":6},"Heilongjiang Provicial Hospital",{"name":66,"class":6},"Ankang Central Hospital",{"name":68,"class":69},"Huadong Hospital Affiliated with Fudan University, Shanghai","UNKNOWN",{"name":71,"class":6},"The First Affiliated Hospital of Nanchang University",{"name":73,"class":6},"Yan'an People's Hospital",{"name":75,"class":6},"The Second Hospital of Hebei Medical University",{"name":77,"class":6},"Chongqing General Hospital",{"name":79,"class":69},"Guangzhou Medical University Affiliated Qingyuan Hospital (Qingyuan People's Hospital)",{"name":81,"class":82},"Shanxi Provincial People's Hospital","OTHER_GOV",{"name":84,"class":69},"Shanghai Sixth Hospital",{"name":86,"class":69},"People's Hospital of Leshan, Sichuan Province",{"name":88,"class":6},"The Third People's Hospital of Chengdu",{"name":90,"class":69},"The Third People's Hospital of Jingdezhen",{"name":92,"class":69},"Ningbo Hospital of Integrated Traditional Chinese and Western Medicine",{"name":94,"class":69},"Shandong Provincial Second People's Hospital","100637721",false,"NCT07601217","Impact of Acetic Acid-Indigo Carmine Chromocolonoscopy on Proximal Sessile Serrated Lesions","Impact of Acetic Acid-Indigo Carmine Chromocolonoscopy on Proximal Sessile Serrated Lesions: a Multicenter Randomized Trial","ACID-SSL","Inclusion Criteria:\n\n* Patients whose age are between 45-85\n* Patients who have indications for screening\n* Patients who have signed inform consent form.\n\nExclusion Criteria:\n\n* Patients undergoing surveillance colonoscopy after polypectomy or therapeutic colonoscopy for known polyps\n* Patients with a history of colonoscopy within the past 5 years\n* Patients with highly suspected or confirmed colorectal cancer\n* Patients with alarming signs or symptoms: hematochezia, melena, unexplained anemia, weight loss, abdominal mass, positive digital rectal examination\n* Pregnant or breastfeeding women\n* Patients with gastrointestinal obstruction\n* Patients with inflammatory bowel disease, colonic polyposis, or melanosis coli\n* Patients with coagulation disorders or who have taken antiplatelets or anticoagulants (e.g., aspirin, warfarin) within 7 days before colonoscopy\n* Patients currently participating in another clinical trial or who have participated in another clinical trial within the preceding 60 days\n* Patients with failed cecal intubation for any reason (e.g., obstructing lesion, intolerance of the procedure)\n* Patients with an Aronchick bowel preparation score \\>3 at colonoscope insertion, indicating inadequate preparation requiring a repeat bowel preparation\n* Patients who have used bowel preparation agents not recommended by guidelines, such as oral sodium phosphate or senna\n* Patients with known allergy to acetic acid-indigo carmine, brilliant blue dye, or medications related to colonoscopy\n* Patients with missing essential information in the case report form prior to enrollment","ALL","45 Years","85 Years",{"count":106,"type":107},2689,"ESTIMATED","INTERVENTIONAL",[110],"NA","Chromocolonoscopy with acetic acid and indigo carmine has shown promise for improving the detection of sessile serrated lesions (SSLs), the precursor lesions responsible for a substantial proportion of interval colorectal cancers. Previous studies have demonstrated its potential to enhance visualization of both adenomatous and non-adenomatous polyps, particularly the subtle SSLs that are frequently missed during conventional white-light colonoscopy. However, high-quality randomized controlled trials comparing chromocolonoscopy with standard white-light imaging to provide definitive evidence on its efficacy for SSL detection are lacking. We therefore conducted a multicenter, prospective, randomized controlled trial to evaluate the diagnostic yield of acetic acid-indigo carmine chromocolonoscopy versus standard colonoscopy for SSL detection.",[113],"Sessile Serrated Lesion",[113,115,116,117],"Sessile Serrated Lesion Detection Rate","Chromocolonoscopy","Acetic Acid and Indigo Carmine","NOT_YET_RECRUITING","2026-05-17",{"date":121,"type":122},"2026-05-22","ACTUAL",{"date":124,"type":107},"2026-06-15",{"date":126,"type":107},"2028-11-15",{"name":5,"class":6},1]