[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561484":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":41,"studyPopulation":32,"armGroups":42,"interventions":58,"overallOfficials":32,"centralContacts":65,"locations":71,"responsibleParty":92,"collaborators":32,"id":95,"slug":32,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":32,"eligibilityCriteria":100,"healthyVolunteers":96,"sex":101,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":32,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":113,"overallStatus":74,"whyStopped":32,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Carmel Medical Center","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":23,"otherOutcomes":32},[9,13,16,19],{"measure":10,"description":11,"timeFrame":12},"Assessing patients' QoL-related concerns will be performed using the Edmonton Symptom Assessment Scale (ESAS)","Assessing the effectiveness and safety of an IO intervention involving acupressure and relaxation, either with or without the addition of acupuncture, on the severity of QoL-related concerns among hospitalized oncology patients. Of the three PROMs, ESAS asks respondents to score a list of 10 QoL-related concerns on a scale from 0 (no symptom) to 10 (worst severity of the symptom).","Before and immediately following the IO intervention; at 24-48 hours; and two weeks post-treatment.",{"measure":14,"description":15,"timeFrame":12},"Assessing patients' QoL-related concerns will be performed using the Measure Yourself Concerns and Wellbeing (MYCAW).","Of the three PROMs used to assess patients' QoL, in MYCAW, patients to list and then score (from 0 to 6; 6 is most severe) their 2 most severe QoL-related concerns.",{"measure":17,"description":18,"timeFrame":12},"Assessing patients' QoL-related concerns will be performed using the European Organization for Research and Treatment of Cancer Quality of Life(EORTC QLQ-C30).","EORTC QLQ C-30 asks a number of QoL-related clusters of concerns, from 1 (not at all) to 4 (very much).",{"measure":20,"description":21,"timeFrame":22},"Assessment of objective physiological changes during the intervention","Assessment of objective physiological changes during the 30-minute intervention will be conducted using chest-lead electrocardiogram monitoring autonomic heart rate variability (HRV) throughout. At the same time, nociceptive levels (NOL) will be monitored using a PMD-200 device (Medasense, Ramat Gan, Israel).","During the 30 minutes intervention",[24,28],{"measure":25,"description":26,"timeFrame":27},"Identifying the most commonly reported QoL-related concerns of hospitalized oncology patients. This based on the Measure Yourself Concerns and Wellbeing (MYCAW) questionnaire.","Identify and evaluating the most commonly reported QoL-related concerns of patients during hospitalization and the indications for which the hospital staff refer them to the IO treatment program. In MYCAW, patients to list and then score (from 0 to 6; 6 is most severe) their 2 most severe QoL-related concerns. In addition to quantitative assessment of patient concerns, a qualitative assessment will be performed using the MYCAW narratives as reported by patients following open-ended questions.","Before and immediately following the 30-minute intervention.",{"measure":29,"description":30,"timeFrame":31},"Identifying barriers and enablers to the continuity of integrative oncology care.This based on the Measure Yourself Concerns and Wellbeing (MYCAW) questionnaire.","Identifying barriers and enablers to the continuity of integrative oncology care for patients with cancer, from the in-patient hospital to the out-patient community care setting. MYCAW questionnaire include also a qualitative segment where patients are asked to report on their feedback and experience following treatment.","Two weeks for patients with localized cancer; 12 weeks for patients with advanced cancer",null,{"allocation":34,"interventionModel":35,"interventionModelDescription":32,"primaryPurpose":36,"observationalModel":32,"timePerspective":32,"maskingInfo":37},"RANDOMIZED","PARALLEL","SUPPORTIVE_CARE",{"masking":38,"maskingDescription":32,"whoMasked":39},"SINGLE",[40],"OUTCOMES_ASSESSOR","Scientific background: The provision of complementary and integrative medicine therapies within supportive and palliative oncology care (herewith, Integrative Oncology, IO) is increasingly taking place in leading oncology centers across the globe. The Society for Integrative Oncology (SIO) and the American Society of Clinical Oncology (ASCO) have co-published clinical practice guidelines on the effective and safe use of these modalities for patients with cancer. The proposed study will explore the provision of IO care to patients with cancer during hospitalization, with the goal of addressing emotional distress, pain, fatigue, gastro-intestinal symptoms, and other quality of life (QoL)-related concerns.\n\nStudy objectives and purpose: The primary study objective is to improve patients' QoL-related concerns while hospitalized for a variety of cancer-related indications. This, in a clinical context in which in-patient IO interventions are provided together with palliative care, with the two teams coordinating their work. Secondary objective is to identify barriers and enablers to the continuity of IO care, following hospitalization, for patients with cancer, from the in-patient hospital to the out-patient community care setting.\n\nMethods: Study design and setting: The proposed study will take place within a prospective randomized controlled methodology, beginning with a patient-preference stage, in which patients are asked to choose whether they are interested in undergoing IO treatments or palliative nursing counseling.\n\nStudy population: Patients of either gender, diagnosed with cancer, age ≥ 18 years and hospitalized in one of the five surgical\u002Finternal departments will be eligible for study inclusion. Participating patients will be referred to the study team by a medical healthcare provider in their respective departments, providing a list of clinical indications for the referral.\n\nAllocation to study arms and groups:\n\nParticipants will be allocated to one of the two primary study arms, based on their preference for undergoing IO treatments:\n\n* Integrative oncology (IO) arm (Groups A and B): Patients choosing to undergo IO treatments, in addition to standard palliative care\n* Palliative nursing counseling (Group C): Patients choosing to undergo a palliative nursing consultation only.\n\nPatients choosing to receive IO care will then be randomly and openly assigned to one of the intervention groups, using the \"Research Randomizer\" online tool (https:\u002F\u002Fwww.randomizer.org\u002F), to one of the following study groups:\n\n* Single-modality IO, receiving acupressure\u002Frelaxation only (Group A)\n* Multi-modality IO receiving acupressure\u002Frelaxation with acupuncture (Group B) IO treatments and palliative nursing consultation: Patients in the intervention arm of the study (groups A and B) will be interviewed and assessed by the IO practitioner, while a palliative nurse specialist will interview those choosing the palliative nursing consultation (Group C). In all study groups, the interviews will address QoL-related concerns, identifying the patient's leading concern (e.g., pain, anxiety). Following the QOL assessment in both groups, an integrative or palliative intervention with the goal of alleviating the patient's leading QoL-related concerns over the next 24-hour period.\n\nPatients in the IO intervention arm of the study will undergo acupressure\u002Frelaxation treatments only (Single Modality, Group A), or with the addition of acupuncture (Multi-Modality, Group B). The acupressure\u002Facupuncture points will be designated according to a protocol for each of the four leading concerns (pain, fatigue, emotional, and gastrointestinal), based on evidence-based research. The palliative nursing intervention (Group C) will entail a personalized bio-psycho-social-oriented discussion, highlighting the patient's and their informal caregiver's unmet needs and QoL-related concerns.",[43,49,53],{"label":44,"type":45,"description":46,"interventionNames":47},"Integrative oncology single-modality","EXPERIMENTAL","Acupressure\u002Frelaxation only",[48],"Other: acupressure\u002Frelaxation with acupuncture",{"label":50,"type":45,"description":51,"interventionNames":52},"Integrative oncology multi-modality","Acupressure\u002Frelaxation with acupuncture",[48],{"label":54,"type":55,"description":56,"interventionNames":57},"Palliative nursing counseling","ACTIVE_COMPARATOR","Patients choosing to undergo a palliative nursing consultation only.",[48],[59],{"type":6,"name":60,"description":61,"armGroupLabels":62,"otherNames":63},"acupressure\u002Frelaxation with acupuncture","The acupressure\u002Facupuncture points will be designated according to a protocol for each of the four leading concerns (pain, fatigue, emotional, and gastrointestinal), based on evidence-based research. For example, clinical guideline-based IO protocols for pain relief will include the following analgesia-related acupressure\u002Facupuncture points: Liver-3, Taichong; Large-Intestine 4, Hegu; Stomach-36, Zusanli; Pericard-6, Neiguan; Spleen-6, Sanyinjiao; Yin tang; as well as battlefield ear acupuncture points. In both IO intervention groups, relaxation techniques will be tailored to the patient's main concern, with the option of including breathing and guided imagery modalities as well.",[50,44,54],[64],"Manual and mind-body therapies",[66],{"name":67,"role":68,"phone":69,"phoneExt":32,"email":70},"Eran Ben-Arye, MD","CONTACT","+97248568333","ERANBE@clalit.org.il",[72],{"facility":73,"status":74,"city":75,"state":76,"zip":77,"country":76,"countryCode":78,"cosmosGeoPoint":79,"geoPoint":84,"contacts":85},"Carmel Medical center","RECRUITING","Haifa","Israel","35152","IL",{"type":80,"coordinates":81},"Point",[82,83],34.99928,32.81303,{"lat":83,"lon":82},[86,90],{"name":67,"role":68,"phone":87,"phoneExt":88,"email":89},"972528709282","0","eranbe@clalit.org.il",{"name":91,"role":68,"phone":32,"phoneExt":32,"email":32},"Eran Ben-Arye",{"type":93,"investigatorFullName":91,"investigatorTitle":94,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Director, Integrative Oncology Program","100561484",false,"NCT06590766","Impact of Acupuncture and Manual Therapies on Patients' Quality-of-life in a Hospital-to-community Continuum","Impact of Acupuncture and Manual Therapies on Patients' Quality-of-life in a Hospital-to-community Continuum of Integrative Oncology and Supportive-palliative Care","Inclusion Criteria:\n\nPatients diagnosed with cancer, age ≥ 18 years and hospitalized in one of the six internal medicine and surgical departments in the hospital.\n\nExclusion Criteria:\n\nInability to read and provide informed consent","ALL","18 Years","100 Years",{"count":105,"type":106},520,"ESTIMATED","INTERVENTIONAL",[109],"NA","Oncology patients often suffer during hospitalization from pain, emotional distress, gastrointestinal symptoms, weakness, and quality of life (QoL)-related concerns. A large body of research has shown that acupuncture and other integrative oncology (IO) modalities, when provided in conjunction with supportive care, can significantly address and alleviate QoL-related concerns. In the proposed study, we examine an innovative model of IO and palliative care, provided to patients with cancer during hospitalization. Oncology patients at the Carmel Medical Center, Haifa, Israel, will be referred by hospital to IO\u002Fpalliative care, specifying the patient's QoL-related concerns. After signing the informed consent form, patients will be asked to choose between IO intervention (Group A and B) or palliative nursing counseling only (Group C). Patients choosing to undergo integrative treatment will be randomly allocated to one of the two study interventions: acupressure-relaxation alone (Group A); or acupressure-relaxation modalities with acupuncture (Group B). The response to the study intervention for QoL-related concerns will be re-assessed immediately; at 24-48 hours; and after 2 weeks following the treatment. Patients will also undergo objective measurements during treatment using Heart Rate Variability (HRV) and Nociception Levels (NOL) to determine the impact of the intervention on their QoL and concerns. In summary, the proposed study will examine the short-term impact of an integrative\u002Fpalliative intervention on patient QoL-related concerns, comparing acupressure-relaxation modalities with or without acupuncture, as well as to patients receiving palliative nursing counseling. Following discharge, treatments will be provided at one of six participating community IO services, over a 12-week period, in coordination with the oncology and palliative care teams in the community.",[112],"Oncology",[114,115,116],"Integrative oncology","Palliative care","Acupuncture","2024-09-10",{"date":119,"type":120},"2024-09-19","ACTUAL",{"date":122,"type":120},"2023-04-18",{"date":124,"type":106},"2027-06-30",{"name":5,"class":6},1]