Health Trials

About this trial

This study is about determining if an aerobic and resistance exercise intervention is feasible in patients diagnosed with acute or chronic GVHD (Graft-Versus-Host Disease) after having an allogeneic stem cell transplant.

The names of the study interventions involved in this study are:

* Aerobic and resistance exercise (A+R) - Home-based aerobic and resistance exercise program * Attention control (AC) - Home-based stretching program

Eligibility criteria

Qualifiers

Over 18 years old; children under the age of 18 will be excluded due to rarity of disease

Newly diagnosed with acute or chronic GVHD, starting corticosteroids at a dose of .20 mg/kg or greater for the first time since transplant

Received allogeneic stem cell transplant (any conditioning, any donor) at Dana-Farber Cancer Institute

Physician's clearance to participate in moderate-vigorous intensity exercise

Disqualifiers

Have a plan for hospital admission within the next 13 weeks at the time of recruitment

If patients are not enrolled within 14 days after initial steroid treatment, they will be ineligible

Pre-existing musculoskeletal or cardiorespiratory conditions

Patients should not have any uncontrolled illness including ongoing or active infection, uncontrolled diabetes, hypertension, or thyroid disease

Trial design

Treatments tested in this trial

  • Exercise
  • Attention control

Treatment groups

36 Participants
are divided into 2 treatment groups

Locations

2
Brigham and Women's Hospital02115, BostonMassachusetts, United States
Dana Farber Cancer Institute02215, BostonMassachusetts, United States

Sponsors and collaborators

Dana-Farber Cancer Institute

Lead sponsor

Source ClinicalTrials.gov