[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637018":3},{"organization":4,"outcomesModule":7,"designInfo":25,"detailedDescription":31,"studyPopulation":24,"armGroups":32,"interventions":50,"overallOfficials":55,"centralContacts":59,"locations":67,"responsibleParty":85,"collaborators":24,"id":88,"slug":24,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":95,"sex":96,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":24,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":109,"overallStatus":69,"whyStopped":24,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"University of Virginia","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":24},[9,13],{"measure":10,"description":11,"timeFrame":12},"Microvascular blood volume in skeletal and cardiac muscle - changes from baseline","insulin-mediated changes in skeletal and cardiac muscle as determined by insulin clamp","Before and after 15 weeks of exercise training",{"measure":14,"description":15,"timeFrame":16},"maximal aerobic exercise capacity","change in VO2max","before and after 15 weeks of exercise training",[18,21],{"measure":19,"description":20,"timeFrame":16},"insulin-mediated whole body glucose disposal","insulin-mediated whole body glucose disposal during insulin clamp",{"measure":22,"description":23,"timeFrame":16},"Muscle capillary density and satellite cells","Changes in muscle capillary density and satellite cells",null,{"allocation":26,"interventionModel":27,"interventionModelDescription":24,"primaryPurpose":28,"observationalModel":24,"timePerspective":24,"maskingInfo":29},"NON_RANDOMIZED","PARALLEL","BASIC_SCIENCE",{"masking":30,"maskingDescription":24,"whoMasked":24},"NONE","This study will test the hypothesis that in humans with T1D skeletal muscle microvascular insulin resistance predicts a reduction in Cardiorespiratory Fitness (CRF) and obesity exacerbates microvascular insulin resistance, leading to further CRF decline, which is mechanistically linked to increased muscle microvascular endothelial oxidative stress, impaired muscle mitochondrial function, reduced muscle capillary density and decreased satellite cells.",[33,39,43,47],{"label":34,"type":35,"description":36,"interventionNames":37},"Type 1 diabetes - normal weight","ACTIVE_COMPARATOR","Type 1 diabetes normal weight",[38],"Other: Exercise training",{"label":40,"type":35,"description":41,"interventionNames":42},"Control - normal weight","healthy control - normal weight",[38],{"label":44,"type":35,"description":45,"interventionNames":46},"Overweight control","Overweight, otherwise healthy",[38],{"label":48,"type":35,"description":48,"interventionNames":49},"Type 1 diabetes - overweight",[38],[51],{"type":6,"name":52,"description":53,"armGroupLabels":54,"otherNames":24},"Exercise training","15 weeks of HIIT exercise training",[40,44,34,48],[56],{"name":57,"affiliation":5,"role":58},"Zhenqi Liu, MD","PRINCIPAL_INVESTIGATOR",[60,65],{"name":61,"role":62,"phone":63,"phoneExt":24,"email":64},"Lee Hartline, MEd","CONTACT","434-924-5247","lmh9d@virginia.edu",{"name":57,"role":62,"phone":24,"phoneExt":24,"email":66},"zl3e@UVAhealth.org",[68],{"facility":5,"status":69,"city":70,"state":71,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"RECRUITING","Charlottesville","Virginia","22908","United States","US",{"type":76,"coordinates":77},"Point",[78,79],-78.47668,38.02931,{"lat":79,"lon":78},[82,83,84],{"name":57,"role":62,"phone":63,"phoneExt":24,"email":66},{"name":61,"role":62,"phone":63,"phoneExt":24,"email":64},{"name":57,"role":58,"phone":24,"phoneExt":24,"email":24},{"type":58,"investigatorFullName":86,"investigatorTitle":87,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Zhenqi Liu","Associate Professor","100637018",false,"NCT07573228","Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes","Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes (","ZQL010","Inclusion Criteria:\n\n* • Male or female ≥21 and ≤50 years old\n\n  * For persons with T1D: Disease duration ≥ 5 years and HbA1c ≤ 8.5% on multiple daily insulin injection or insulin pump\n  * Body mass index: ≥19 and ≤27 kg\u002Fm2 for control and T1D, ≥30 and ≤40 kg\u002Fm2 (27.5 to 37.5 for Asian Americans) for obesity and T1D + obesity. BMI is limited to ≤40 kg\u002Fm2 (37.5 for Asian Americans) for easier vascular access and cardiac imaging.\n  * Stable use of non-insulin medications for over 6 months other than estrogen\u002Fprogesterone containing medications which must be discontinued at least 3 months prior to the study (intrauterine devices may be continued due to limited systemic absorption)\n\nExclusion Criteria:\n\n* • Acute or chronic disease other than T1D or obesity\n\n  * History of microvascular or macrovascular diabetes complications\n  * History of diabetic ketoacidosis in the past 24 months\n  * History of hypoglycemia unawareness\n  * Recently active (\\>20 min of moderate\u002Fhigh intensity exercise, 2 times\u002Fweek)\n  * Subjects who are smokers or who have quit smoking \\\u003C5 years\n  * Subjects with hypertriglyceridemia (\\>400 mg\u002Fdl)\n  * Current use of vasoactive medications (i.e. calcium channel blockers, angiotensin-converting enzyme or renin inhibitors, angiotensin-receptor blockers, nitrates, alpha- or beta-blockers, or diuretics).\n  * Females taking oral contraceptives in the past 3 months\n  * Subjects with a history of significant metabolic, cardiac, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or malignancy\n  * Pregnant (as evidenced by positive pregnancy test) or nursing women\n  * Musculoskeletal condition preventing participation in exercise testing or exercise training\n  * History of gastroparesis\n  * Pulse oximetry \\\u003C90%",true,"ALL","21 Years","50 Years",{"count":100,"type":101},60,"ESTIMATED","INTERVENTIONAL",[104],"NA","The purpose of this study is:\n\n* To see if insulin resistance (how sensitive your muscle tissue is to insulin) is associated with lower cardio fitness in people with Type 1 diabetes compared to healthy controls, before and after a High Intensity Interval Training (HIIT) exercise program.\n* To see if being overweight and having Type 1 diabetes is associated with lower cardio fitness compared to overweight healthy controls, before and after a HIIT exercise program.",[107,108],"Type 1 Diabetes","Overweight",[110,52,111,112],"Type 1 diabetes","healthy controls","overweight","2026-05-01",{"date":115,"type":116},"2026-05-07","ACTUAL",{"date":118,"type":116},"2026-02-23",{"date":120,"type":101},"2030-06-30",{"name":5,"class":6},1]