[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100419027":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":156,"collaborators":10,"id":158,"slug":10,"hasResults":159,"nctId":160,"briefTitle":161,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":159,"sex":164,"minAge":165,"maxAge":166,"enrollmentInfo":167,"targetDuration":10,"studyType":170,"phases":10,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":187},{"fullName":5,"class":6},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Kidney transplanted patients treated with Nulojix",null,"Patients treated with Simulect as induction, and with Nulojix®, mycophenolic acid and steroids as maintenance therapy during the first year of kidney transplant.",[13],"Drug: Belatacept Injection [Nulojix]",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Belatacept Injection [Nulojix]","Drugs administrated are part of the usual care",[9],[21,22,23],"Simulect","Mycophenolate mofetil","Steroid",[25],{"name":26,"affiliation":5,"role":27},"Antoine Durrbach, MD-PhD","PRINCIPAL_INVESTIGATOR",[29,33],{"name":26,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","+33614112981","antoine.durrbach@inserm.fr",{"name":34,"role":30,"phone":35,"phoneExt":10,"email":36},"florence Herr, PhD","+33663680985","florence.herr@inserm.fr",[38,55,69,83,96,106,116,129,142],{"facility":39,"status":40,"city":41,"state":10,"zip":42,"country":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Nephrologie transplantation CHRU Besançon","RECRUITING","Besançon","25000","France",{"type":45,"coordinates":46},"Point",[47,48],6.01815,47.24878,{"lat":48,"lon":47},[51],{"name":52,"role":30,"phone":53,"phoneExt":10,"email":54},"Jamal BAMOULID","+33 3 81 21 81 97","jbamoulid@chu-besancon.fr",{"facility":56,"status":40,"city":57,"state":10,"zip":58,"country":43,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Néphrologie, hémodialyse, aphérèses, transplantation rénale","La Tronche","38700",{"type":45,"coordinates":60},[61,62],5.74629,45.20507,{"lat":62,"lon":61},[65],{"name":66,"role":30,"phone":67,"phoneExt":10,"email":68},"Paolo MALVEZZI","+33 4 76 76 54 60","PMalvezzi@chu-grenoble.fr",{"facility":70,"status":40,"city":71,"state":10,"zip":72,"country":43,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Nephrologie transplantation CHRU Nantes","Nantes","44200",{"type":45,"coordinates":74},[75,76],-1.55336,47.21725,{"lat":76,"lon":75},[79],{"name":80,"role":30,"phone":81,"phoneExt":10,"email":82},"Gilles BLANCHO","+33 2 40 08 74 53","gblancho@chu-nantes.fr",{"facility":84,"status":40,"city":85,"state":10,"zip":86,"country":43,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Nephrologie transplantation CHU Saint Louis Paris","Paris","75010",{"type":45,"coordinates":88},[89,90],2.3488,48.85341,{"lat":90,"lon":89},[93],{"name":94,"role":30,"phone":10,"phoneExt":10,"email":95},"Carmen LEFAUCHEUR","carmen.lefaucheur@aphp.fr",{"facility":97,"status":40,"city":85,"state":10,"zip":98,"country":43,"cosmosGeoPoint":99,"geoPoint":101,"contacts":102},"Nephrologie transplantation CHU Pitié Salpetriere Paris","75013",{"type":45,"coordinates":100},[89,90],{"lat":90,"lon":89},[103],{"name":104,"role":30,"phone":10,"phoneExt":10,"email":105},"Alexandre HERTIG","alexandre.hertig@aphp.fr",{"facility":107,"status":40,"city":85,"state":10,"zip":108,"country":43,"cosmosGeoPoint":109,"geoPoint":111,"contacts":112},"Nephrologie hôpital Henri-Mondor","94010 Créteil",{"type":45,"coordinates":110},[89,90],{"lat":90,"lon":89},[113],{"name":114,"role":30,"phone":115,"phoneExt":10,"email":32},"Antoine DURRBACH","+33 1 49 51 44 51",{"facility":117,"status":40,"city":118,"state":10,"zip":119,"country":43,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Nephrologie transplantation CHRU Poitiers","Poitiers","86021",{"type":45,"coordinates":121},[122,123],0.34348,46.58261,{"lat":123,"lon":122},[126],{"name":127,"role":30,"phone":10,"phoneExt":10,"email":128},"Antoine THIERRY","antoine.thierry@chu-poitiers.fr",{"facility":130,"status":40,"city":131,"state":10,"zip":132,"country":43,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"Nephrologie transplantation CHRU Toulouse","Toulouse","31059 Toulouse Cedex 9",{"type":45,"coordinates":134},[135,136],1.44367,43.60426,{"lat":136,"lon":135},[139],{"name":140,"role":30,"phone":10,"phoneExt":10,"email":141},"Nassim KAMAR","kamar.n@chu-toulouse.fr",{"facility":143,"status":40,"city":144,"state":10,"zip":145,"country":43,"cosmosGeoPoint":146,"geoPoint":150,"contacts":151},"Nephrologie transplantation CHRU Tours","Tours","37044",{"type":45,"coordinates":147},[148,149],0.70398,47.39484,{"lat":149,"lon":148},[152],{"name":153,"role":30,"phone":154,"phoneExt":10,"email":155},"Mathias BUCHLER","+33 2 47 47 37 46","mathias.buchler@univ-tours.fr",{"type":157,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100419027",false,"NCT04736381","Impact of the Microbiota on the Likelihood of Renal Graft Rejection","MERRLIN","Inclusion Criteria:\n\n* Patients called for a kidney transplant\n* Induction therapy with Simulect, maintenance therapy with Nulojix, mycophenolate acid and steroids\n* Patient having signed the informed consent\n\nExclusion Criteria:\n\n* Multiple grafts combined or sequential\n* Induction therapy with polyclonal antibodies\n* HIV or active viral infection such as hepatitis B or C\n* Active bacterial infection\n* Pregnancy or breastfeeding at time of inclusion\n* Patient unable to express their consent","ALL","18 Years","70 Years",{"count":168,"type":169},70,"ESTIMATED","OBSERVATIONAL","Identification of a bacterial signature in the blood or stool that may be associated with acute rejection in patients treated with Nulojix during their first year of transplant.",[173],"Kidney Transplant Rejection",[175,176,177],"Microbiota","Belatacept","Second signal inhibitor","2025-04-09",{"date":180,"type":181},"2025-04-10","ACTUAL",{"date":183,"type":181},"2021-10-07",{"date":185,"type":169},"2027-01-07",{"name":5,"class":6},9]