[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644654":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":30,"locations":39,"responsibleParty":60,"collaborators":63,"id":66,"slug":21,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":21,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":93,"overallStatus":99,"whyStopped":21,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Kessler Foundation","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"participants with chronic SCIs.","EXPERIMENTAL","Participation in this study will take about 5 to 6 months and will include approximately 30 to 40 separate lab visits. Most visits will last about 2 hours, though some of the early visits may take longer.\n\nThe study consists of:\n\n1. Baseline assessments, including a tilt test and various cardiovascular assessments\n2. Mapping stimulation sessions - several days when different stimulation parameters and locations are tested in order to obtain the configurations for the most suitable blood pressure response.\n3. Repeat tilt test, with stimulation (intervention 1), with continuous blood pressure monitoring\n4. 20 stimulation sessions, each 30-min long, with participants in their wheelchairs (intervention 2)\n5. Repeat baseline assessments",[13,14],"Device: Tilt test with stimulation (real-time effects): Intervention 1","Device: 20 sessions of stimulation (Intervention 2)",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DEVICE","Tilt test with stimulation (real-time effects): Intervention 1","While lying supine, participants will be strapped to a Hi-Low tilt-table bed. The bed will gradually be tilted to a 70 degrees tilt, during which time continuous hemodynamic measures will be recorded. This position will be maintained for 30 minutes. During tilt, transcutaneous stimulation will be applied, using the configuration that was chosen based on the mapping sessions.",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"20 sessions of stimulation (Intervention 2)","Participants will undergo 20 separate 30-minute sessions of transcutaneous spinal cord stimulation while seated in their wheelchairs",[9],[27],{"name":28,"affiliation":5,"role":29},"Gail F Forrest, PhD","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":21,"email":35},"LeighAnn Martinez, BA","CONTACT","972-324-3557","lmartinez@kesslerfoundation.org",{"name":37,"role":33,"phone":21,"phoneExt":21,"email":38},"Einat Engel-Haber, MD","ehaber@kesslerfoundation.org",[40],{"facility":5,"status":21,"city":41,"state":42,"zip":43,"country":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"West Orange","New Jersey","07052","United States",{"type":46,"coordinates":47},"Point",[48,49],-74.23904,40.79871,{"lat":49,"lon":48},[52,54,55,56,59],{"name":32,"role":33,"phone":53,"phoneExt":21,"email":35},"(973)324-3557",{"name":37,"role":33,"phone":21,"phoneExt":21,"email":38},{"name":28,"role":29,"phone":21,"phoneExt":21,"email":21},{"name":57,"role":58,"phone":21,"phoneExt":21,"email":21},"Steven Kirshblum, MD","SUB_INVESTIGATOR",{"name":37,"role":58,"phone":21,"phoneExt":21,"email":21},{"type":29,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"Einat Haber","Research scientist",[64],{"name":65,"class":6},"Montclair State University","100644654",false,"NCT07674511","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury: Short and Long-Term Effects","(SCI)","Inclusion Criteria:\n\n* Individuals with a SCI ≥ 1 year after injury\n* Injury level ≥ T6 (thoracic level)\n* AIS grade A-C\n* Cardiovascular dysfunction characterized by one or more of the following:\n\n  1. Persistent hypotension (SBP \\\u003C 90mmHg)\n  2. Orthostatic hypotension (OH, a drop of 20\u002F10 mmHg in SBP\u002FDBP within 5 minutes of standing\u002Fupright positioning).\n\nAdditionally, experiencing orthostatic symptoms in daily life and\u002For requiring medication to manage OH.\n\nExclusion Criteria:\n\n* Current illness (e.g., infection, a pressure injury that might interfere with the intervention)\n* Ventilator-dependent\n* History of implanted brain\u002Fspine\u002Fnerve stimulators\n* Cardiac pacemaker\u002Fdefibrillator or intra-cardiac lines\n* Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction\n* History of seizures\n* pregnancy\n* Insufficient mental capacity to understand and independently provide consent\n* Deemed unsuitable by the study physician","ALL","18 Years","75 Years",{"count":77,"type":78},10,"ESTIMATED","INTERVENTIONAL",[81],"NA","The purpose of this study is to learn whether stimulation applied to the spinal cord through the skin (called transcutaneous spinal stimulation) can help control blood pressure in people with a spinal cord injury.\n\nThe main questions this study attempts to solve:\n\n1. What are the immediate effects of spinal cord transcutaneous stimulation on BP?\n2. Does stimulation produce lasting improvements in BP regulation and subsequently, daily function?",[84,85,86,87,88,89,90,91,92],"Spinal Cord Injuries","Hypotension","Orthostatic Hypotension","Spinal Cord Diseases","Cardiovascular Diseases","Trauma, Nervous System","Central Nervous System Disease","Nervous System Diseases","Blood Pressure",[94,95,96,97,98],"transcutaneous spinal cord stimulation","spinal stimulations","orthostatic hypotension","blood pressure","neuromodulation","NOT_YET_RECRUITING","2026-06-24",{"date":102,"type":103},"2026-06-29","ACTUAL",{"date":105,"type":78},"2026-09",{"date":107,"type":78},"2028-12",{"name":5,"class":6},1]