[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543893":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":7,"locations":8,"responsibleParty":32,"collaborators":34,"id":37,"slug":7,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":38,"sex":44,"minAge":7,"maxAge":7,"enrollmentInfo":45,"targetDuration":7,"studyType":48,"phases":7,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":11,"whyStopped":7,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},{"fullName":5,"class":6},"Fondazione IRCCS Istituto Nazionale dei Tumori, Milano","OTHER",null,[9],{"facility":10,"status":11,"city":12,"state":7,"zip":13,"country":14,"cosmosGeoPoint":15,"geoPoint":20,"contacts":21},"Fondazione IRCCS Istituto Nazionale dei Tumori","RECRUITING","Milan","20133","Italy",{"type":16,"coordinates":17},"Point",[18,19],9.18951,45.46427,{"lat":19,"lon":18},[22,27,30],{"name":23,"role":24,"phone":25,"phoneExt":7,"email":26},"Alessandro Cicchetti, PhD","CONTACT","0223903858","alessandro.cicchetti@istitutotumori.mi.it",{"name":28,"role":24,"phone":7,"phoneExt":7,"email":29},"Chiara Casati","chiara.casati@istitutotumori.mi.it",{"name":23,"role":31,"phone":7,"phoneExt":7,"email":7},"PRINCIPAL_INVESTIGATOR",{"type":33,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[35],{"name":36,"class":6},"Politecnico di Milano","100543893",false,"NCT06361784","Improving the Success Rate for Thoracic Radiotherapy Through Specific Cardiac Substructure Dosimetry: Location Matters. (LOCATION MATTERS)","\"Improving the Success Rate for Thoracic Radiotherapy Through Specific Cardiac Substructure Dosimetry: Location Matters - a Prospective Study\"","LM","Inclusion Criteria:\n\n* Patients with NSCLC\n* Patients with locally advanced disease (Stage 3)\n* Patients treated with RT at Fondazione IRCCS Istituto Nazionale dei Tumori\n\nExclusion Criteria:\n\n* Previous thoracic radiotherapy\n* Previous heart surgery","ALL",{"count":46,"type":47},150,"ESTIMATED","OBSERVATIONAL","The prospective study LOCATION MATTERS aims to investigate the radiation-induced damage to the heart and the cardiovascular system in patients treated with thoracic radiotherapy. Patients enrolled in the study will complete a set of extensive measures at the baseline, end of RT, and 9 months after treatment. Ultrasound exams, CT scans, pulmonary tests and wearable devices will assess functional and morphological parameters and the association with their variation and the dose delivered to the heart substructures and to the normal lung.",[51],"Locally Advanced Lung Non-Small Cell Carcinoma",[53,54,55,56,57],"cardiotoxicity","adverse events","heart substructures","MACE","subclinical warnings","2024-04-12",{"date":60,"type":61},"2024-04-15","ACTUAL",{"date":63,"type":61},"2024-03-29",{"date":65,"type":47},"2029-03-29",{"name":5,"class":6},1]