[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563019":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":42,"collaborators":10,"id":45,"slug":10,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":10,"enrollmentInfo":53,"targetDuration":10,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},{"fullName":5,"class":6},"Leiden University Medical Center","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Elderly patients with a suspected urinary tract infection",null,[12],"Diagnostic Test: Urine Biomarkers",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DIAGNOSTIC_TEST","Urine Biomarkers","At baseline midstream urine will be collected in a sterile urine container.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Nora El Moussaoui","CONTACT","0031-0634531571","n.el_moussaoui@lumc.nl",[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Leiden university medical center (LUMC)","RECRUITING","Leiden","South Holland","2333 ZA","Netherlands",{"type":34,"coordinates":35},"Point",[36,37],4.49306,52.15833,{"lat":37,"lon":36},[40],{"name":21,"role":22,"phone":41,"phoneExt":10,"email":24},"0031634531571",{"type":43,"investigatorFullName":21,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","drs. N. El Moussaoui","100563019",false,"NCT06610721","'Improving Urinary Tract Infection Diagnosis in Older Patients: Validation of a Biomarker Panel (UTI-GOLD)'","UTI-GOLD","Inclusion criteria:\n\n* Age 65 years or older\n* Clinically suspected UTI by treating physician\n* Sufficient understanding of the Dutch language\n\nExclusion criteria:\n\n* Inability to obtain urine\n* Inability to provide written consent\n* The presence of an indwelling catheter","ALL","65 Years",{"count":54,"type":55},264,"ESTIMATED","OBSERVATIONAL","The goal of this study is to improve the diagnosis of urinary tract infections (UTI) in older people (≥65 years). The main research questions are:\n\nResearch questions\n\n* What is the optimal cut-off for each individual biomarker NGAL,IL-6,AZU,TIMP2 and CXCL9 and associated, sensitivity, specificity, negative and positive predictive value.\n* sensitivity, specificity, negative and positive predictive value of a urine leukocyte count cut-off of 200 cells\u002FmicroL (validation)\n* What is the optimal combination of biomarkers for UTI diagnosis in older patients\n* As a secondary objective this study aims to evaluate the association between the levels of individual biomarker levels and 1) duration of symptoms 2) complications, 3) recurrence of UTI within 2 months, and length of hospital stay. Next to this, the performance of the astrego PA100 will be validated in diagnosing bacteriuria.\n\nParticipants will:\n\n* be asked to provide a urine sample once at the beginning of the study\n* be asked to answer some questions about their symptoms and overall health at the beginning of the study and after 8 weeks\n* have their vital parameters (temperature and blood pressure) measured once at the beginning of the study",[59],"Urinary Tract Infection (Diagnosis)",[61,62],"Urinary tract infection","Biomarkers","2024-09-23",{"date":65,"type":66},"2024-09-24","ACTUAL",{"date":68,"type":66},"2024-08-20",{"date":70,"type":55},"2026-10-15",{"name":5,"class":6},1]