[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100341978":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":19,"interventions":13,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":59,"collaborators":13,"id":61,"slug":13,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":13,"enrollmentInfo":71,"targetDuration":13,"studyType":74,"phases":13,"briefSummary":75,"conditions":76,"keywords":13,"overallStatus":43,"whyStopped":13,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Göteborg University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Inflammatory status","The inflammatory status will be studied in patients with atherosclerotic disease.","2019-2024",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","Vascular reconstruction surgeries usually require a small piece of the vessel wall to be excised. The excised vessel is generally discarded as medical waste: however, for patients participating in the study, the excised tissue will be placed in saline and collected for research use.\n\nTissue collected from individuals undergoing vascular surgery associated with peripheral arterial diseases, aneurysm and\u002For other manifestations of atherosclerosis, vascular tissue will be cultured ex vivo in the presence or absence of therapeutic agents, to determine if these attenuate the inflammation associated with the atherosclerotic phenotype. Furthermore, the protocol will also be carried out using vascular tissue from control patients, which have undergone vascular surgery that is not associated with vascular disease (e.g. knee replacement surgery, trauma, etc).","Consecutive patients planned for vascular reconstruction surgery at our center.",[20,23],{"label":21,"type":13,"description":22,"interventionNames":13},"Control patients","Control patients (n=20): In individuals undergoing vascular surgery that is not associated with vascular disease (e.g. knee replacement surgery, trauma, etc), a piece of healthy vessel must sometimes be removed in order to facilitate the surgical process. The vessel biopsies from this group will be categorized as \"healthy vessels\" in our study.",{"label":24,"type":13,"description":25,"interventionNames":13},"Study patients","Study patients (n=150): In individuals undergoing vascular surgery associated with peripheral arterial diseases, aneurysm and\u002For other manifestations of atherosclerosis, vascular tissue is sometimes excised to facilitate the surgery. Biopsies from these individuals will be categorized as \"vessels with vascular dysfunction\".",[27],{"name":28,"affiliation":29,"role":30},"Jan Boren, MD, PhD","The University of Gothenburg","STUDY_DIRECTOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":13,"email":36},"Emma Borgeson, PhD","CONTACT","+46313420000","emma.borgeson@wlab.gu.se",{"name":38,"role":34,"phone":35,"phoneExt":13,"email":39},"Per Skoog, MD, PhD","per.skoog@vgregion.se",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"University of Gothenburg","RECRUITING","Gothenburg","Vastragotaland","40530","Sweden","SE",{"type":50,"coordinates":51},"Point",[52,53],11.96679,57.70716,{"lat":53,"lon":52},[56,58],{"name":33,"role":34,"phone":57,"phoneExt":13,"email":13},"+4631342000",{"name":38,"role":34,"phone":57,"phoneExt":13,"email":13},{"type":60,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100341978",false,"NCT03732612","Inflammation in Vascular Disease","The Role of Inflammation in Vascular Disease (Inflammationens Roll i kärlsjukdom)","REBEL","Inclusion Criteria:\n\n* Patient is planned to undergo vascular surgery.\n* Signed informed consent has been obtained from the patient.\n\nExclusion Criteria:\n\n* Patient has difficulty to understand information.\n* Patients under 18 years of age.\n* Patients participating in any drug-related study.",true,"ALL","18 Years",{"count":72,"type":73},170,"ESTIMATED","OBSERVATIONAL","Increasing evidence suggests that systemic low-grade inflammation may be a driving force of cardiometabolic complications, such as vascular dysfunction, atherosclerosis and ischemic heart disease. Thus, we will investigate the role of inflammation in cardiovascular disease.",[77,78],"Vascular Diseases","Atherosclerosis","2025-05-05",{"date":81,"type":82},"2025-05-06","ACTUAL",{"date":84,"type":82},"2019-09-02",{"date":86,"type":73},"2027-02-01",{"name":5,"class":6},1]