Inflammatory and Metabolic Prognostic Assessment in Critically Ill Neurological Patients
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorYan Zhang
About this trial
The study aims to develop and validate a prognostic prediction model for adverse outcomes in neurocritical patients receiving enteral nutrition based on key inflammatory and metabolic markers. This model will serve as a clinical tool to help physicians identify high-risk patients and guide individualized nutritional support strategies.
Eligibility criteria
Qualifiers
Age between 18 and 80 years, no gender restrictions.
Within 7 days of disease onset and expected NICU stay of at least 7 days.
Eligible for enrollment within 24 hours of NICU admission, with enteral nutrition (EN) initiated and continued for at least 7 days.
Non-traumatic severe brain injury patients (including cerebrovascular disease and encephalitis) with a Glasgow Coma Scale (GCS) score ≤12.
Disqualifiers
Severe malnutrition prior to admission, defined as BMI < 16 kg/m².
Pregnant or lactating women.
Receiving hypothermia treatment or core body temperature < 36°C.
End-stage disease with an expected survival time of < 48 hours, or severe dysfunction of the heart, lungs, or other vital organs, leading to hemodynamic instability.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
1,185 Participants
are grouped into 5 trial groupsLocations
19Beijing Hui People's Hospital100053, BeijingBeijing Municipality, China
The Ninth Medical Center of Chinese PLA General Hospital100700, BeijingBeijing Municipality, China
Xuanwu Hospital, Capital Medical University100053, BeijingBeijing Municipality, China
You'anmen Hospital100069, BeijingBeijing Municipality, China
Sponsors and collaborators
Yan Zhang
Lead sponsor
Xuanwu Hospital, Beijing
Sponsor institution
Source ClinicalTrials.gov