[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581338":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":22,"locations":32,"responsibleParty":299,"collaborators":10,"id":302,"slug":10,"hasResults":303,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":303,"sex":309,"minAge":310,"maxAge":311,"enrollmentInfo":312,"targetDuration":10,"studyType":315,"phases":10,"briefSummary":316,"conditions":317,"keywords":321,"overallStatus":326,"whyStopped":10,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":336},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8,12,14,16,19],{"label":9,"type":10,"description":11,"interventionNames":10},"mild Inflammation & Metabolic dysfunction",null,"First, a predictive model for poor prognosis is constructed through screening of independent variables after data collection. Then, stratified analysis is conducted with inflammatory markers such as C-reactive protein and interleukin-6, and metabolic markers such as blood glucose and insulin dosage.",{"label":13,"type":10,"description":11,"interventionNames":10},"Moderate Inflammation & Metabolic Dysregulation",{"label":15,"type":10,"description":11,"interventionNames":10},"High Inflammation & Severe Metabolic Dysregulation",{"label":17,"type":10,"description":18,"interventionNames":10},"Peptide-Based Nutrition","Select patients who received peptide-based formulas from the entire database for poor prognosis analysis.",{"label":20,"type":10,"description":21,"interventionNames":10},"Whole Protein Nutrition","Select patients who received whole protein formulas from the database for poor prognosis analysis.",[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Yan Zhang, MD., Ph D.","CONTACT","8613671376710","zhangylq@sina.com",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},"Fei Tian, MD., Ph D.","8618201303685","smile21tian@163.com",[33,50,58,69,80,95,110,124,139,154,169,184,199,214,229,244,255,269,284],{"facility":34,"status":10,"city":35,"state":36,"zip":37,"country":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Beijing Hui People's Hospital","Beijing","Beijing Municipality","100053","China",{"type":40,"coordinates":41},"Point",[42,43],116.39723,39.9075,{"lat":43,"lon":42},[46],{"name":47,"role":25,"phone":48,"phoneExt":10,"email":49},"Yanbo He","8618612691914","htyopen@163.com",{"facility":51,"status":10,"city":35,"state":36,"zip":37,"country":38,"cosmosGeoPoint":52,"geoPoint":54,"contacts":55},"Xuanwu Hospital, Capital Medical University",{"type":40,"coordinates":53},[42,43],{"lat":43,"lon":42},[56],{"name":57,"role":25,"phone":26,"phoneExt":10,"email":27},"Yan Zhang",{"facility":59,"status":10,"city":35,"state":36,"zip":60,"country":38,"cosmosGeoPoint":61,"geoPoint":63,"contacts":64},"You'anmen Hospital","100069",{"type":40,"coordinates":62},[42,43],{"lat":43,"lon":42},[65],{"name":66,"role":25,"phone":67,"phoneExt":10,"email":68},"Dan Xin","8615321688898","1195048308@qq.com",{"facility":70,"status":10,"city":35,"state":36,"zip":71,"country":38,"cosmosGeoPoint":72,"geoPoint":74,"contacts":75},"The Ninth Medical Center of Chinese PLA General Hospital","100700",{"type":40,"coordinates":73},[42,43],{"lat":43,"lon":42},[76],{"name":77,"role":25,"phone":78,"phoneExt":10,"email":79},"Juan Du","8613901362737","juanzijuanzi@263.net",{"facility":81,"status":10,"city":82,"state":83,"zip":84,"country":38,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"The 940th Hospital of Joint Logistics Support Force of Chinese PLA","Lanzhou","Gansu","730050",{"type":40,"coordinates":86},[87,88],103.83987,36.05701,{"lat":88,"lon":87},[91],{"name":92,"role":25,"phone":93,"phoneExt":10,"email":94},"Xiaoyan Zhang","8613919931411","zhangxiaoyan060110@163.com",{"facility":96,"status":10,"city":97,"state":98,"zip":99,"country":38,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Guizhou Provincial People's Hospital","Guiyang","Guizhou","550002",{"type":40,"coordinates":101},[102,103],106.71667,26.58333,{"lat":103,"lon":102},[106],{"name":107,"role":25,"phone":108,"phoneExt":10,"email":109},"Xiao Hu","8618096105119","18096105119@163.com",{"facility":111,"status":10,"city":112,"state":98,"zip":113,"country":38,"cosmosGeoPoint":114,"geoPoint":118,"contacts":119},"Affiliated Hospital of Zunyi Medical University","Zunyi","563003",{"type":40,"coordinates":115},[116,117],106.90722,27.68667,{"lat":117,"lon":116},[120],{"name":121,"role":25,"phone":122,"phoneExt":10,"email":123},"Zucai Xu","8613368663217","docxzc@126.com",{"facility":125,"status":10,"city":126,"state":127,"zip":128,"country":38,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Tangshan People's Hospital","Tangshan","Hebei","063000",{"type":40,"coordinates":130},[131,132],118.18319,39.64381,{"lat":132,"lon":131},[135],{"name":136,"role":25,"phone":137,"phoneExt":10,"email":138},"Yan Wang","8613333299772","doctor_wy@163.com",{"facility":140,"status":10,"city":141,"state":142,"zip":143,"country":38,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"The First Hospital of Hebei Medical University","Shijiazhuang","Heibei","050031",{"type":40,"coordinates":145},[146,147],114.47861,38.04139,{"lat":147,"lon":146},[150],{"name":151,"role":25,"phone":152,"phoneExt":10,"email":153},"Jia Tian","8615097392050","15097392050@163.com",{"facility":155,"status":10,"city":156,"state":157,"zip":158,"country":38,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Inner Mongolia Autonomous Region People's Hospital","Hohhot","Inner Mongolia","010017",{"type":40,"coordinates":160},[161,162],111.65222,40.81056,{"lat":162,"lon":161},[165],{"name":166,"role":25,"phone":167,"phoneExt":10,"email":168},"Runxiu Zhu","8618047191885","zhurunxiu@163.com",{"facility":170,"status":10,"city":171,"state":172,"zip":173,"country":38,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"The Second Affiliated Hospital of Suzhou University","Suzhou","Jiangsu","215004",{"type":40,"coordinates":175},[176,177],120.59538,31.30408,{"lat":177,"lon":176},[180],{"name":181,"role":25,"phone":182,"phoneExt":10,"email":183},"Jijun Shi","8615895551663","shijijun2008@126.com",{"facility":185,"status":10,"city":186,"state":187,"zip":188,"country":38,"cosmosGeoPoint":189,"geoPoint":193,"contacts":194},"The First Hospital of Jilin University","Jilin City","Jilin","130021",{"type":40,"coordinates":190},[191,192],126.5608,43.84652,{"lat":192,"lon":191},[195],{"name":196,"role":25,"phone":197,"phoneExt":10,"email":198},"Jie Cao","8613756947788","cjie@jlu.edu.cn",{"facility":200,"status":10,"city":201,"state":202,"zip":203,"country":38,"cosmosGeoPoint":204,"geoPoint":208,"contacts":209},"Chifeng Municipal Hospital","Chifeng","Neimenggu","024000",{"type":40,"coordinates":205},[206,207],118.96361,42.26833,{"lat":207,"lon":206},[210],{"name":211,"role":25,"phone":212,"phoneExt":10,"email":213},"Huijie Zhou","8613948690409","1031581493@qq.com",{"facility":215,"status":10,"city":216,"state":217,"zip":218,"country":38,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"General Hospital of Ningxia Medical University","Yinchuan","Ningxia","750004",{"type":40,"coordinates":220},[221,222],106.27306,38.46806,{"lat":222,"lon":221},[225],{"name":226,"role":25,"phone":227,"phoneExt":10,"email":228},"Tao Guo","8613895092758","zfgt1@163.com",{"facility":230,"status":10,"city":231,"state":232,"zip":233,"country":38,"cosmosGeoPoint":234,"geoPoint":238,"contacts":239},"Qilu Hospital of Shandong University","Jinan","Shandong","250012",{"type":40,"coordinates":235},[236,237],116.99722,36.66833,{"lat":237,"lon":236},[240],{"name":241,"role":25,"phone":242,"phoneExt":10,"email":243},"Qinzhou Wang","8618560085523","qinzhouwang@163.com",{"facility":245,"status":10,"city":231,"state":232,"zip":246,"country":38,"cosmosGeoPoint":247,"geoPoint":249,"contacts":250},"The 960th Hospital of Joint Logistics Support Force of Chinese PLA","250031",{"type":40,"coordinates":248},[236,237],{"lat":237,"lon":236},[251],{"name":252,"role":25,"phone":253,"phoneExt":10,"email":254},"Huaiqiang Hu","8613156189722","huhuaiqiang@126.com",{"facility":256,"status":10,"city":257,"state":232,"zip":258,"country":38,"cosmosGeoPoint":259,"geoPoint":263,"contacts":264},"Liaocheng People's Hospital","Liaocheng","252000",{"type":40,"coordinates":260},[261,262],116.00247,36.45064,{"lat":262,"lon":261},[265],{"name":266,"role":25,"phone":267,"phoneExt":10,"email":268},"Dong Guo","8613396258699","guodonglc@126.com",{"facility":270,"status":10,"city":271,"state":272,"zip":273,"country":38,"cosmosGeoPoint":274,"geoPoint":278,"contacts":279},"The Second Hospital of Shanxi Medical University","Taiyuan","Shanxi","030001",{"type":40,"coordinates":275},[276,277],112.56028,37.86944,{"lat":277,"lon":276},[280],{"name":281,"role":25,"phone":282,"phoneExt":10,"email":283},"Liansheng Ma","8615935111597","zly4200@sina.com",{"facility":285,"status":10,"city":286,"state":287,"zip":288,"country":38,"cosmosGeoPoint":289,"geoPoint":293,"contacts":294},"The First People's Hospital of Yunnan Province","Kunming","Yunnan","650032",{"type":40,"coordinates":290},[291,292],102.71833,25.03889,{"lat":292,"lon":291},[295],{"name":296,"role":25,"phone":297,"phoneExt":10,"email":298},"Lei Zhang","8613759176858","845585258@qq.com",{"type":300,"investigatorFullName":57,"investigatorTitle":301,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Professor","100581338",false,"NCT06849011","Inflammatory and Metabolic Prognostic Assessment in Critically Ill Neurological Patients","Development and Validation of a Prognostic Prediction Model for Adverse Outcomes in Neurocritical Patients Receiving Enteral Nutrition Based on Key Inflammatory and Metabolic Markers","IMPACT-NEURO","Inclusion Criteria:\n\n1. Age between 18 and 80 years, no gender restrictions.\n2. Within 7 days of disease onset and expected NICU stay of at least 7 days.\n3. Eligible for enrollment within 24 hours of NICU admission, with enteral nutrition (EN) initiated and continued for at least 7 days.\n4. Non-traumatic severe brain injury patients (including cerebrovascular disease and encephalitis) with a Glasgow Coma Scale (GCS) score ≤12.\n5. NRS 2002 score ≥3.\n6. Kuwata drinking test ≥ grade 3.\n7. Acute Gastrointestinal Injury (AGI) grade 1 or 2.\n8. Signed informed consent obtained from the patient or their legal representative.\n\nExclusion Criteria:\n\n1. Severe malnutrition prior to admission, defined as BMI \\\u003C 16 kg\u002Fm².\n2. Pregnant or lactating women.\n3. Receiving hypothermia treatment or core body temperature \\\u003C 36°C.\n4. End-stage disease with an expected survival time of \\\u003C 48 hours, or severe dysfunction of the heart, lungs, or other vital organs, leading to hemodynamic instability.\n5. Malignant tumors.","ALL","18 Years","80 Years",{"count":313,"type":314},1185,"ESTIMATED","OBSERVATIONAL","The study aims to develop and validate a prognostic prediction model for adverse outcomes in neurocritical patients receiving enteral nutrition based on key inflammatory and metabolic markers. This model will serve as a clinical tool to help physicians identify high-risk patients and guide individualized nutritional support strategies.",[318,319,320],"Stroke Acute","Encephalitis","Non-traumatic Brain Injury",[322,323,324,325],"enteral nutrition","adverse prognosis","prediction model","non-traumatic severe brain injury","NOT_YET_RECRUITING","2025-02-23",{"date":329,"type":330},"2025-02-27","ACTUAL",{"date":332,"type":314},"2025-03-01",{"date":334,"type":314},"2027-03-31",{"name":57,"class":6},19]