[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620404":3},{"organization":4,"outcomesModule":7,"designInfo":34,"detailedDescription":37,"studyPopulation":38,"armGroups":39,"interventions":44,"overallOfficials":20,"centralContacts":49,"locations":55,"responsibleParty":75,"collaborators":20,"id":77,"slug":20,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":78,"sex":84,"minAge":85,"maxAge":20,"enrollmentInfo":86,"targetDuration":20,"studyType":89,"phases":20,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":58,"whyStopped":20,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Centre Hospitalier Régional d'Orléans","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Fugl-Meyer Assessment for Upper Extremity (FMA-UE) Score","Upper-limb motor impairment measured using the Fugl-Meyer Assessment for the Upper Extremity (FMA-UE) at 6 months post-stroke. Scores range from 0 to 66, with higher scores indicating less impairment. Primary analysis is performed among participants with baseline FMA-UE less than 66.","month 6",[14,18,21,24,27,30],{"measure":15,"description":16,"timeFrame":17},"Mean Fugl-Meyer Assessment for Upper Extremity (FMA-UE) Score","Score from 0 to 66; the lower the score, the more severe the deficit","Baseline",{"measure":19,"description":20,"timeFrame":17},"Proportion of Left-Handed Participants",null,{"measure":22,"description":23,"timeFrame":17},"Mean National Institutes of Health Stroke Scale (NIHSS) Score","Score from 0 to 42; the higher the score, the more severe the deficit",{"measure":25,"description":26,"timeFrame":17},"Number of Participants With Upper-Limb Weakness","Number of Participants With Upper-Limb Weakness Defined as SAFE Score Less Than 10",{"measure":28,"description":29,"timeFrame":17},"Correlation Between Edinburgh Handedness Inventory Laterality Quotient and Baseline FMA-UE Score","Score from -100 to +100, no notion of severity here since it assesses manual preference (at -100 you are very left-handed and at +100 you are very right-handed)",{"measure":31,"description":32,"timeFrame":33},"Mean Shoulder Abduction and Finger Extension (SAFE) Score","Score from 0 to 10; the lower the score, the more severe the deficit.","Month 6",{"allocation":20,"interventionModel":20,"interventionModelDescription":20,"primaryPurpose":20,"observationalModel":35,"timePerspective":36,"maskingInfo":20},"COHORT","PROSPECTIVE","Participants hospitalized in the stroke unit with a confirmed unilateral stroke are recruited consecutively. After eligibility verification and absence of objection, baseline data are collected within 5 days post-stroke. Baseline assessments include the Fugl-Meyer Assessment for the Upper Extremity (FMA-UE), the Shoulder Abduction and Finger Extension (SAFE) score, and the National Institutes of Health Stroke Scale (NIHSS) score (post-acute treatment if thrombolysis or thrombectomy was performed). Handedness is recorded after the motor assessments to maintain assessor blinding regarding group membership; the Edinburgh Handedness Inventory is administered when cognitive status allows. A 6-month follow-up is performed during routine post-stroke consultation at the study site, with repeat FMA-UE and SAFE assessments. The primary analysis compares FMA-UE at 6 months between left-handed and right-handed participants among those with baseline FMA-UE less than 66, using propensity score matching (3:1 right-handed to left-handed) accounting for age, baseline motor deficit, lesion side relative to dominance (dominant vs non-dominant hemisphere), and stroke type (ischemic vs hemorrhagic).","Adults hospitalized in the stroke unit of Orléans University Hospital with a confirmed unilateral recent stroke.",[40],{"label":41,"type":20,"description":20,"interventionNames":42},"Patients with confirmed unilateral recent stroke",[43],"Other: evaluation",[45],{"type":6,"name":46,"description":47,"armGroupLabels":48,"otherNames":20},"evaluation","Patients will be evaluated at baseline for Edinburgh Handedness Inventory Laterality Quotient. Patients will be seen again at 6 months as part of their standard post-stroke consultation at Orléans University Hospital by a neurologist from the neurology department. In conjunction with this consultation, an assessment specific to this research study of the FMA-UE and SAFE scores will be carried out by a physiotherapist from the department.",[41],[50],{"name":51,"role":52,"phone":53,"phoneExt":20,"email":54},"Julien BONNAL, MK","CONTACT","00332 38 74 46 65","julien.bonnal@chu-orleans.fr",[56],{"facility":57,"status":58,"city":59,"state":20,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"CHU Orléans","RECRUITING","Orléans","45067","France","FR",{"type":64,"coordinates":65},"Point",[66,67],1.90407,47.90248,{"lat":67,"lon":66},[70,72],{"name":51,"role":52,"phone":71,"phoneExt":20,"email":54},"0033238744665",{"name":73,"role":74,"phone":20,"phoneExt":20,"email":20},"Julien BONNAL","PRINCIPAL_INVESTIGATOR",{"type":76,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100620404",false,"NCT07357181","Influence of Handedness on Upper Limb Recovery","Impact of Manual Preference on Motor Deficits After Stroke","HANDISTROKE","Inclusion Criteria:\n\n1. Confirmed unilateral recent stroke (less than 5 days).\n2. Age 18 years and older.\n3. Participant or proxy does not object to participation\n\nExclusion Criteria:\n\n1. Prior stroke with residual motor sequelae.\n2. Pre-stroke upper-limb deficit.\n3. Follow-up at 6 months not planned at Orléans.\n4. Protected adult (guardianship\u002Fcuratorship), person under legal protection, or deprived of liberty.\n5. Pregnant or breastfeeding woman.","ALL","18 Years",{"count":87,"type":88},500,"ESTIMATED","OBSERVATIONAL","This prospective, single-center observational study evaluates whether handedness is associated with upper-limb motor recovery after a recent unilateral stroke. Adults admitted to the stroke unit with a confirmed unilateral stroke within 5 days are included if they do not object to participation. Upper-limb impairment is assessed early after stroke and at 6 months using standardized clinical scales. Handedness is determined by self-report, and the Edinburgh Handedness Inventory is administered when feasible. The main hypothesis is that left-handed participants may show better upper-limb motor recovery at 6 months than right-handed participants, potentially due to differences in brain motor network lateralization.",[92],"Stroke",[92,94,95,96,97,98,99],"Handedness","Motricity","Upper Limb","Manual preference","Motor impairment","Motor recovery","2026-06-05",{"date":102,"type":103},"2026-06-08","ACTUAL",{"date":105,"type":103},"2026-06-02",{"date":107,"type":88},"2028-10",{"name":5,"class":6},1]