[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602998":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":10,"locations":23,"responsibleParty":45,"collaborators":47,"id":50,"slug":10,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":10,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":70,"overallStatus":26,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Central Hospital, Nancy, France","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intra-abdominal candidiasis",null,"Intra-abdominal infection with intra-abdominal candidiasis based on the FUNDICU consensus",[13],"Other: Immunomonitoring",{"label":15,"type":10,"description":16,"interventionNames":17},"Bacterial Intra-abdominal infection","Intra-abdominal infection with a negative fungal culture",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Immunomonitoring","To analyse monocyte HLA-DR expression (mHLA-DR) and CD4+ T lymphocyte count (CD4) in both group",[15,9],[24],{"facility":25,"status":26,"city":27,"state":10,"zip":28,"country":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"CHRU de NANCY","RECRUITING","Vandœuvre-lès-Nancy","54500","France",{"type":31,"coordinates":32},"Point",[33,34],6.17114,48.66115,{"lat":34,"lon":33},[37,42],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Emmanuel NOVY, MD, PhD","CONTACT","+33 383157437","e.novy@chru-nancy.fr",{"name":43,"role":44,"phone":10,"phoneExt":10,"email":10},"Anne-Claire LUKASZEWICZ, MD,PhD","PRINCIPAL_INVESTIGATOR",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[48],{"name":49,"class":6},"Hospices Civils de Lyon","100602998",false,"NCT07130799","Innate Immune Response Monitoring Via Monocyte HLA-DR in Severe Intra-abdominal Infections at Risk of Fungal Infection","Evaluation of the Innate Immune Response Through Monocyte HLA-DR Monitoring During Severe Intra-abdominal Candidiasis in the Critically Ill Patients","CANDIRIS","Inclusion Criteria:\n\n* Adult patient (≥ 18 years old)\n* Patient admitted to the ICU or intermediate care unit for a severe intra-abdominal infection requiring urgent abdominal surgery\n* Presence of at least one risk factor for intra-abdominal candidiasis:\n\n  * Abdominal surgery within the last 7 days\n  * Supramesocolic gastrointestinal perforation\n  * Healthcare-associated intra-abdominal infection\n  * Community-acquired intra-abdominal infection in an immunocompromised patient\\*\n  * Intra-abdominal infection complicated by septic shock\n  * Broad-spectrum antibiotic exposure within 72 hours prior to surgery\n* And\u002For a Peritonitis Score ≥ 3 out of 4\n* Patient affiliated with or benefiting from a national health insurance system\n* Patient who has received full information about the clinical study\n\nExclusion Criteria:\n\n* Radiologically guided drainage without surgery\n* Infected acute pancreatitis\n* Limitation or withdrawal of life-sustaining treatments\n* Moribund patient with an expected life expectancy \\\u003C 48 hours\n* Woman of childbearing potential without effective contraception\n* Refusal to participate in the study","ALL","18 Years",{"count":60,"type":61},100,"ESTIMATED","OBSERVATIONAL","Intra-abdominal candidiasis (IAC) is a frequent and severe fungal infection in critically ill patients, often diagnosed late. Its pathophysiology remains unclear, particularly regarding why some patients develop invasive infection while others only show benign colonization. A potential explanation lies in the state of innate immunity. Monocyte HLA-DR expression, a recognized marker of immune suppression in critical care, may be transiently but profoundly reduced in non-immunocompromised patients who go on to develop IAC. This observational study aims to evaluate whether patients with IAC have greater innate immune dysfunction-assessed by HLA-DR expression-compared to those with severe bacterial intra-abdominal infections. The goal is to better understand the immune mechanisms involved and improve early risk stratification for IAC.",[65,66,67,68,69],"Intra-abdominal Infection","Critical Illness","Post-Op Infection","Immunization; Sepsis","Candida Sepsis",[71,72,73,74,75,76],"intra-abdominal infection","intra-abdominal candidiasis","HLA-DR","immunomonitoring","monocyte","critically ill patients","2026-02-05",{"date":79,"type":80},"2026-02-09","ACTUAL",{"date":82,"type":80},"2025-11-14",{"date":84,"type":61},"2027-03-01",{"name":5,"class":6},1]