[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561290":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":36,"collaborators":10,"id":40,"slug":10,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":41,"sex":47,"minAge":10,"maxAge":10,"enrollmentInfo":48,"targetDuration":51,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":21,"whyStopped":10,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},{"fullName":5,"class":6},"Federico II University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"INOCA",null,"Patients presenting with symptoms or signs of myocardial ischemia with non-obstructing coronary artery disease",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Luigi Di Serafino, MD, PhD","CONTACT","0039 347917374","luigi.diserafino@unina.it",[19],{"facility":20,"status":21,"city":22,"state":23,"zip":24,"country":23,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"DPT of Advanced Biomedical Sciences","RECRUITING","Naples","Italy","80131",{"type":26,"coordinates":27},"Point",[28,29],14.26811,40.85216,{"lat":29,"lon":28},[32],{"name":33,"role":15,"phone":34,"phoneExt":10,"email":35},"Stefano Cristiano","+300817463075","stefano.cristiano@unina.it",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Luigi Di Serafino","Principal Investigator, Clinical Professor","100561290",false,"NCT06588244","INOCA-NA a Local Prospective Registry","Ischemia in Patients with Non- Obstructive Disease (INOCA) - a Local Prospective Registry (INOCA-Naples)","INOCA-NA","Inclusion Criteria:\n\n* Clinical presentation of chronic ischemic heart dis- ease (IHD), requiring coronary angiography for the diagnosis;\n* Absence of obstructive coronary artery disease (CAD) at coronary angiography;\n* Age \\> 18 years.\n* Ability to provide a valid informed consent to the study procedure at the time of baseline evaluation;\n\nExclusion Criteria:\n\nClinical presentation of acute coronary syndrome (ACS) or cardiogenic shock;\n\n* Presence of obstructive CAD with at least 1 significant coronary artery stenosis, defined as diameterstenosis \\>50% and FFR ≤0.80 (or iFR\u002FRFR ≤0.89);\n* Previous coronary artery bypass grafting (CABG);\n* Left ventricular systolic dysfunction, defined as ejection fraction (EF) \\<40%;\n* Severe valvular heart disease;\n* Pregnant or breastfeeding women\n* Known hypersensitivity or contraindication to any of the drugs used for coronary physiology testing (adenosine, nitrates, acetylcholine)\n* Inability or unwillingness to provide a valid in- formed consent to the study procedure at the time of baseline evaluation.","ALL",{"count":49,"type":50},250,"ESTIMATED","1 Year","OBSERVATIONAL","The present study has the following objectives:\n\n1. To investigate the prevalence of INOCA in patients referring for a clinically indicated coronary angiography (CA) c\u002Fo Division of Cardiology - Federico II University Hospital;\n2. To stratify in INOCA endotypes patients according to the presence or absence of alternative (i.e. non obstructive CAD) causes of myocardial ischemia detected during CA clinically indicated through physiology tests;\n3. to implement a stratified therapy in these patients considering the different INOCA endotypes and evaluate the impact on angina class and quality of life as well as cardiac hospitalization and coronary revascularization during 5 year follow up",[55,56,57,58],"Ischemia, Myocardial","Non-Obstructive Coronary Atherosclerosis","Microcirculatory Status","Coronary Microvascular Dysfunction (CMD)",[9,60,61],"CMD","VSA","2025-03-12",{"date":64,"type":65},"2025-03-17","ACTUAL",{"date":67,"type":65},"2024-09-19",{"date":69,"type":50},"2027-09-01",{"name":5,"class":6},1]