[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631061":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":11,"studyPopulation":31,"armGroups":11,"interventions":11,"overallOfficials":32,"centralContacts":41,"locations":46,"responsibleParty":60,"collaborators":11,"id":64,"slug":11,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":11,"maxAge":72,"enrollmentInfo":73,"targetDuration":76,"studyType":77,"phases":11,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":48,"whyStopped":11,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Guangdong Provincial People's Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":15,"otherOutcomes":11},[9,13],{"measure":10,"description":11,"timeFrame":12},"death",null,"From enrollment to the event, assessed through study completion (target follow-up duration of 10 years; extended follow-up available for earlier enrollees)",{"measure":14,"description":11,"timeFrame":12},"transplantation",[16,19,21,23,26],{"measure":17,"description":11,"timeFrame":18},"PH-related hospitalization","From enrollment to first occurrence of the event, assessed through study completion (continue to be followed after event occurrence until primary outcome or study completion)",{"measure":20,"description":11,"timeFrame":18},"atrial septostomy",{"measure":22,"description":11,"timeFrame":18},"Potts shunt",{"measure":24,"description":25,"timeFrame":18},"clinical worsening","Clinical worsening is defined as the first occurrence of death, transplantation, hospitalization for PH, atrial septostomy or Potts shunt, with need for escalation of PH-targeted therapy, or worsening functional status.",{"measure":27,"description":11,"timeFrame":18},"decline in WHO functional class",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":29,"timePerspective":30,"maskingInfo":11},"COHORT","PROSPECTIVE","This registry includes children and adolescents diagnosed with PH who are enrolled at participating centers. Patients are followed longitudinally with standardized collection of clinical, functional, imaging and hemodynamic data, with treatment strategies in a real-world setting, allowing evaluation of epidemiology, disease progression, and long-term outcomes.",[33,36,39],{"name":34,"affiliation":5,"role":35},"Zhi-Cheng Jing, Prof.","STUDY_CHAIR",{"name":37,"affiliation":5,"role":38},"Shu-Shui Wang, Prof.","STUDY_DIRECTOR",{"name":40,"affiliation":5,"role":38},"Jie-Xin Zhang, Dr.",[42],{"name":40,"role":43,"phone":44,"phoneExt":11,"email":45},"CONTACT","+86-18629534652","jx_zhang_vip@163.com",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":11},"RECRUITING","Guangzhou","Guangdong","510080","China","CN",{"type":55,"coordinates":56},"Point",[57,58],113.25,23.11667,{"lat":58,"lon":57},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Zhi-Cheng Jing, MD","Prof.","100631061",false,"NCT07495774","Insights Into Pediatric Pulmonary Hypertension: A Real-World Registry of Epidemiology and Outcomes","Insights Into Epidemiology, Management, and Outcomes of Pediatric Pulmonary Hypertension: The INSPIRE-PH Multicenter Real-World Registry","INSPIRE-PPH","Inclusion Criteria:\n\n* Children and adolescents aged \\\u003C18 years at diagnosis\n* Diagnosed pulmonary hypertension (PH) according to the prevailing diagnostic criteria at the time of enrollment\n* Enrollment in the registry at participating centers\n* Provision of informed consent by patients and\u002For legal guardians\n* Availability for longitudinal follow-up\n\nExclusion Criteria:\n\n* Inability to confirm PH diagnosis due to insufficient clinical or hemodynamic data\n* Refusal or inability to provide informed consent","ALL","18 Years",{"count":74,"type":75},450,"ESTIMATED","10 Years","OBSERVATIONAL","Pediatric pulmonary hypertension (PH) shares similarities with PH in adulthood, but specific differences still require unique approaches. Despite major advances, risk scores for pediatric PH still need to be validated, and targeted drug therapies in pediatric populations remain under-studied. Consequently, there is a great need for comprehensive real-world longitudinal data of pediatric PH.\n\nThe INSPIRE-PH registry is a multicenter, observational, real-world registry designed to systematically collect longitudinal clinical data on children and adolescents with PH. Patients enrolled in the registry receive standard clinical care determined by their treating physicians. No study-mandated interventions are imposed. Longitudinal observation of this cohort aims to provide important insights into disease progression, treatment effectiveness, and long-term prognosis in pediatric PH.\n\nThe cohort was initially established prospectively in 2006, with all cases reclassified according to the 7th World Symposium for Pulmonary Hypertension (WSPH) criteria in 2024, and new patients continue to be prospectively enrolled. The registry is supervised by the principal investigator, independently from the financial sponsors.",[80],"Pulmonary Hypertension",[82,83,84,85,86],"pediatric","pulmonary hypertension","real-world","epidemiology","outcome","2026-03-24",{"date":89,"type":90},"2026-03-27","ACTUAL",{"date":92,"type":90},"2006-01-04",{"date":94,"type":75},"2035-12-31",{"name":5,"class":6},1]