[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608787":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":17,"locations":23,"responsibleParty":119,"collaborators":121,"id":129,"slug":7,"hasResults":130,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":130,"sex":136,"minAge":7,"maxAge":7,"enrollmentInfo":137,"targetDuration":7,"studyType":140,"phases":7,"briefSummary":141,"conditions":142,"keywords":152,"overallStatus":26,"whyStopped":7,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":167},{"fullName":5,"class":6},"Hospital Universitari Vall d'Hebron Research Institute","OTHER",null,[9,13],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"GENETIC","Analysis of genetic modifiers","Genetic modifiers for rare anemia disorders will be analyzed through massive sequencing.",{"type":14,"name":15,"description":16,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Disease phenotyping","Peripheral blood samples will be used for conventional phenotyping characterization including among others: RBCs morphology, fragility osmotic test, hemoglobin fraction and quantification, hemoglobin stability test, EMA binding test, RBC enzymes quantification assay, RBC rheological properties through Lorrca Maxsis Osmoscan\u002FOxygescan (Lorrca®)",[18],{"name":19,"role":20,"phone":21,"phoneExt":7,"email":22},"Mar Mañú Pereira PhD","CONTACT","+34 93 489 4063","mar.manu@vhir.org",[24,41,49,60,71,80,91,102,110],{"facility":25,"status":26,"city":27,"state":27,"zip":28,"country":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Hospital de la Santa Creu i Sant Pau","RECRUITING","Barcelona","08025","Spain",{"type":31,"coordinates":32},"Point",[33,34],2.15899,41.38879,{"lat":34,"lon":33},[37],{"name":38,"role":20,"phone":39,"phoneExt":7,"email":40},"Anna collado gimbert","680810602","annacolladogimbert@gmail.com",{"facility":42,"status":26,"city":27,"state":27,"zip":43,"country":29,"cosmosGeoPoint":44,"geoPoint":46,"contacts":47},"Hospital Universitari Vall d'Hebron","08035",{"type":31,"coordinates":45},[33,34],{"lat":34,"lon":33},[48],{"name":38,"role":20,"phone":39,"phoneExt":7,"email":40},{"facility":50,"status":26,"city":51,"state":27,"zip":52,"country":29,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"Hospital Sant Joan de Déu","Esplugues de Llobregat","08950",{"type":31,"coordinates":54},[55,56],2.08809,41.37732,{"lat":56,"lon":55},[59],{"name":38,"role":20,"phone":39,"phoneExt":7,"email":40},{"facility":61,"status":26,"city":62,"state":27,"zip":63,"country":29,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Hospital General de Granollers","Granollers","08402",{"type":31,"coordinates":65},[66,67],2.28773,41.60797,{"lat":67,"lon":66},[70],{"name":38,"role":20,"phone":39,"phoneExt":7,"email":40},{"facility":72,"status":26,"city":73,"state":27,"zip":74,"country":29,"cosmosGeoPoint":75,"geoPoint":79,"contacts":7},"Consorci Sanitari del Maresme - Hospital de Mataró","Mataró","08304",{"type":31,"coordinates":76},[77,78],2.4445,41.54211,{"lat":78,"lon":77},{"facility":81,"status":26,"city":82,"state":27,"zip":83,"country":29,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Parc Taulí Hospital Universitari","Sabadell","08208",{"type":31,"coordinates":85},[86,87],2.10942,41.54329,{"lat":87,"lon":86},[90],{"name":38,"role":20,"phone":39,"phoneExt":7,"email":40},{"facility":92,"status":26,"city":93,"state":27,"zip":94,"country":29,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"Hospital Universitari Mútua de Terrassa","Terrassa","08221",{"type":31,"coordinates":96},[97,98],2.01667,41.56667,{"lat":98,"lon":97},[101],{"name":38,"role":20,"phone":39,"phoneExt":7,"email":40},{"facility":103,"status":26,"city":93,"state":27,"zip":104,"country":29,"cosmosGeoPoint":105,"geoPoint":107,"contacts":108},"Consorci Sanitari de Terrassa","08227",{"type":31,"coordinates":106},[97,98],{"lat":98,"lon":97},[109],{"name":38,"role":20,"phone":39,"phoneExt":7,"email":40},{"facility":111,"status":26,"city":112,"state":112,"zip":113,"country":29,"cosmosGeoPoint":114,"geoPoint":118,"contacts":7},"Hospital Universitari Arnau de Vilanova","Lleida","25198",{"type":31,"coordinates":115},[116,117],0.62218,41.61674,{"lat":117,"lon":116},{"type":120,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[122,124,126],{"name":123,"class":6},"Hospital Clinic of Barcelona",{"name":125,"class":6},"Institute for Bioengineering of Catalonia",{"name":127,"class":128},"Hospital Arnau de Vilanova, Lleida (Spain)","UNKNOWN","100608787",false,"NCT07206095","Integrative Diagnosis for SCD and Other RADs","Integrative Diagnosis of Sickle Cell Disease (SCD) and Other Rare Anemia Disorders (RADs) for Personalized Medicine","INTEGRA","Inclusion Criteria:\n\n* Patients sustaining a confirmed or suspected diagnosis of an hereditary rare hemolytic anemia:\n* Sickle cell disease\n* Thalassemic syndromes\n* Congenital dyserythropoietic anemia\n* Enzymopathy\n* Unstable Hemoblogin \u002F Altered oxygen affinity\n* Hereditary stomatocytosis\n* Hereditary pyropoikilocytosis\n* Hereditary spherocytosis with severe anemia (\\\u003C8 g\u002FdL) or inconclusive diagnosis:\n* Patient with chronic hemolytic anemia and red cell smear compatible, but with:\n* EMA binding test: inconclusive or negative\n* Genetic testing: no definitive diagnosis (VUS or no findings)\n* Not transplanted or undergoing gene therapy at the time of inclusion. Patients with graft failure without a new transplant may be included.\n\nExclusion Criteria:\n\n* Carrier traits in autosomal recessive hereditary anemias","ALL",{"count":138,"type":139},200,"ESTIMATED","OBSERVATIONAL","INTEGRA aims at enabling personalized medicine for RHADs patients by the establishment of an integrative diagnostic approach based on deep phenotypic and genetic characterization through combining new generation methodologies.",[143,144,145,146,147,148,149,150,151],"Sickle Cell Disease","Thalassaemia","Congenital Dyserythropoietic Anemia (CDA)","Enzyme Disorder; Anemia","Spherocytosis, Hereditary","Stomatocytosis","Hemoglobin Disorder","Anemia Due to Membrane Defect","Rare Anemia Disorders",[153,154,155,156,157],"SICKLE CELL DISEASE","RARE ANEMIA DISORDERS","PERSONALIZED MEDICINE","DIAGNOSIS","EKTACYTOMETRY","2025-09-25",{"date":160,"type":161},"2025-10-03","ACTUAL",{"date":163,"type":161},"2020-11-13",{"date":165,"type":139},"2028-05",{"name":5,"class":6},9]