With 50 patients included, this trial would be the largest pilot study evaluating the value of MRI PET in locally advanced rectal cancer. On the other hand, it would be the only pilot study performing several MRI PET during neoadjuvant treatment. Presumably, the response assessed at the 2nd MRI PET (before cycle 4 or induction chemotherapy) would be predictive of the overall response at the end of neoadjuvant treatment. Then, it would be possible to predict precociously the tumor response.
World Health Organization (WHO)/Eastern Cooperative Oncology Group (ECOG) 0 to 2
Histologically proven rectal cancer
clinical tumor classification (cT) : cT3 - cT4 or all T / N+ / M0
Tumor resectable or considered resectable after chemoradiotherapy
Subject with Uncontrolled diabetes
Contraindication to surgery
Contraindication to MRI
Contraindication to PET scan
Centre Paul Strauss
Lead sponsor