[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645287":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":40,"locations":46,"responsibleParty":59,"collaborators":61,"id":63,"slug":44,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":44,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":44,"enrollmentInfo":71,"targetDuration":44,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":90,"whyStopped":44,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Universita di Verona","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A (Hyadrol®)","ACTIVE_COMPARATOR","Participants receive intra-articular injections of adelmidrol 2% \u002F hyaluronic acid 1% (Hyadrol®) administered once weekly for three consecutive weeks.",[13],"Device: Adelmidrol 2% \u002F Hyaluronic Acid 1%",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B (Hyadrol® + m-\u002Fum-PEA)","EXPERIMENTAL","Participants receive intra-articular injections of adelmidrol 2% \u002F hyaluronic acid 1% (Hyadrol®) administered once weekly for three consecutive weeks, combined with oral micronized\u002Fultramicronized palmitoylethanolamide (m-\u002Fum-PEA) (Normast® MPS), one sachet twice daily for 6 weeks, followed by 1 sachet daily for 8 weeks.",[13,19],"Dietary Supplement: micronized Palmitoylethanolamide (mPEA) 300mg + ultramicronized Palmitoylethanolamide (umPEA) 600mg",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Adelmidrol 2% \u002F Hyaluronic Acid 1%","Ultrasound-guided intra-articular knee injection, 2 mL per injection, administered once weekly for three weeks.",[9,15],[27],"Hyadrol®",{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DIETARY_SUPPLEMENT","micronized Palmitoylethanolamide (mPEA) 300mg + ultramicronized Palmitoylethanolamide (umPEA) 600mg","Oral administration of m-\u002Fum-PEA, one sachet twice daily for 6 weeks, followed by 1 sachet daily for 8 weeks.",[15],[34],"Normast® MPS",[36],{"name":37,"affiliation":38,"role":39},"Enrico Polati","Università di Verona, Dipartimento di Scienze Chirurgiche Odontostomatologiche e Materno-Infantili","PRINCIPAL_INVESTIGATOR",[41],{"name":37,"role":42,"phone":43,"phoneExt":44,"email":45},"CONTACT","+39 045 812 6076",null,"enrico.polati@aovr.veneto.it",[47],{"facility":48,"status":44,"city":49,"state":44,"zip":44,"country":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Azienda Ospedaliera Universitaria Integrata Verona","Verona","Italy",{"type":52,"coordinates":53},"Point",[54,55],10.9938,45.43854,{"lat":55,"lon":54},[58],{"name":37,"role":42,"phone":44,"phoneExt":44,"email":45},{"type":60,"investigatorFullName":44,"investigatorTitle":44,"investigatorAffiliation":44,"oldNameTitle":44,"oldOrganization":44},"SPONSOR",[62],{"name":48,"class":6},"100645287",false,"NCT07680101","Intra-Articular Adelmidrol 2%\u002FHyaluronic Acid 1% With or Without m\u002FumPEA, in Knee Pain Due to Joint Degeneration.","Efficacy of Intra-articular Treatment With Adelmidrol 2% \u002F Hyaluronic Acid 1%, With or Without m\u002FumPEA, in Knee Pain Due to Joint Degeneration: a Bicentric, Prospective, Randomized Study.","Inclusion Criteria:\n\n* Age ≥ 40 years\n* Male or female\n* Diagnosis of unilateral or bilateral knee joint degeneration due to osteoarthritis or rheumatoid arthritis, Kellgren-Lawrence grade II-III\n* Duration of knee pain ≥ 6 months\n* Baseline WOMAC score ≥ 20\n* Drug therapy stabilized for at least 3 months in the case of patients with rheumatoid arthritis\n* Naïve to palmitoylethanolamide treatment\n* Signed informed consent\n\nExclusion Criteria:\n\n* Severe progressive systemic diseases\n* Contraindications to intra-articular knee injections\n* Intra-articular knee injections within 3 months prior to enrollment\n* Knee surgery within 6 months prior to enrollment\n* Systemic treatment with chondroprotectors within 1 month prior to enrollment\n* Systemic corticosteroid treatment within 1 month prior to enrollment\n* Chronic Non-Steroidal Anti-Inflammatory Drugs (NSAID) therapy\n* Pregnancy or breastfeeding\n* Known hypersensitivity to study treatments","ALL","40 Years",{"count":72,"type":73},80,"ESTIMATED","INTERVENTIONAL",[76],"NA","Degenerative knee joint diseases are characterized by chronic pain, inflammation, and functional impairment. In these conditions, mast cell density in the synovial membrane is increased, resulting in an excessive release of biological mediators involved in key mechanisms of neuroinflammation and in hyaluronic acid depolymerisation. Adelmidrol acts as a preventive antioxidant due to its radical scavenging activity, thus protecting hyaluronic acid from oxidative degradation and reducing mast cell degranulation. Furthermore, a reduction in endogenous Palmitoylethanolamide (PEA) levels also contributes to joint neuroinflammation and disease progression; therefore, its exogenous supplementation may represent a valuable supportive strategy.\n\nThe objective of this clinical investigation is to compare the efficacy of intra-articular adelmidrol\u002Fhyaluronic acid treatment alone versus the same intra-articular treatment combined with oral micronized \u002Fultramicronized PEA in patients with knee joint degeneration due to osteoarthritis or rheumatoid arthritis.",[79,80],"Degenerative Joint Disease of Knee","Rheumatoid Arthritis",[82,83,84,85,86,87,88,89],"Neuroinflammation","Palmitoylethanolamide","Adelmidrol","Hyaluronic Acid","Intra-Articular Injection","Knee Pain","Arthritis, Rheumatoid","Osteoarthritis, Knee","NOT_YET_RECRUITING","2026-06-25",{"date":93,"type":94},"2026-07-02","ACTUAL",{"date":96,"type":73},"2026-06",{"date":98,"type":73},"2027-06",{"name":5,"class":6},1]