[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100378566":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":53,"centralContacts":57,"locations":66,"responsibleParty":88,"collaborators":42,"id":91,"slug":42,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":42,"eligibilityCriteria":96,"healthyVolunteers":92,"sex":97,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":42,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":113,"overallStatus":69,"whyStopped":42,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Peking University First Hospital","OTHER",[8,15,21,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Routine blood pressure management + placebo","PLACEBO_COMPARATOR","Blood pressure is maintained according to routine practice. Placebo (normal saline 2 ml) is administered before anesthesia induction.",[13,14],"Drug: Placebo","Other: Routine blood presure management",{"label":16,"type":17,"description":18,"interventionNames":19},"Routine blood pressure management + dexamethasone","EXPERIMENTAL","Blood pressure is maintained according to routine practice. Dexamethasone (10 mg\u002F2 ml) ia administered before anesthesia induction.",[20,14],"Drug: Dexamethasone",{"label":22,"type":17,"description":23,"interventionNames":24},"Targeted blood pressure management + placebo","Blood pressure is maintained within ±10% from baseline. Placebo (normal saline 2 ml) is administered before anesthesia induction.",[25,13],"Other: Targeted blood pressure management",{"label":27,"type":17,"description":28,"interventionNames":29},"Targeted blood pressure management + dexamethasone","Blood pressure is maintained within ±10% from baseline. Dexamethasone (10 mg\u002F2 ml) is administered before anesthesia induction.",[20,25],[31,38,43,49],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DRUG","Dexamethasone","Dexamethasone (10 mg\u002F2 ml) is administered before anesthesia induction.",[16,27],[37],"Glucocorticoids",{"type":6,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Targeted blood pressure management","Blood pressure is maintained within ±10% from baseline.",[27,22],null,{"type":32,"name":44,"description":45,"armGroupLabels":46,"otherNames":47},"Placebo","Placebo (2 ml normal saline) is administered before anesthesia induction.",[9,22],[48],"Normal saline",{"type":6,"name":50,"description":51,"armGroupLabels":52,"otherNames":42},"Routine blood presure management","Blood pressure is maintained according to routine practice.",[16,9],[54],{"name":55,"affiliation":5,"role":56},"Dong-Xin Wang, MD, PhD","PRINCIPAL_INVESTIGATOR",[58,62],{"name":55,"role":59,"phone":60,"phoneExt":42,"email":61},"CONTACT","86 (10) 83572784","wangdongxin@hotmail.com",{"name":63,"role":59,"phone":64,"phoneExt":42,"email":65},"Wen-Wen Huang, MD","86 (10) 83572460","hww9215@163.com",[67],{"facility":68,"status":69,"city":70,"state":71,"zip":72,"country":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":80},"Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital","RECRUITING","Beijing","Beijing Municipality","100034","China",{"type":75,"coordinates":76},"Point",[77,78],116.39723,39.9075,{"lat":78,"lon":77},[81,82,85,87],{"name":55,"role":59,"phone":60,"phoneExt":42,"email":61},{"name":83,"role":59,"phone":64,"phoneExt":42,"email":84},"Yi-Bin Hua, MD","huayibin@126.com",{"name":63,"role":86,"phone":42,"phoneExt":42,"email":42},"SUB_INVESTIGATOR",{"name":55,"role":56,"phone":42,"phoneExt":42,"email":42},{"type":56,"investigatorFullName":89,"investigatorTitle":90,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"Dong-Xin Wang","Chairman, Department of Anaesthesiology and Critical Care Medicine","100378566",false,"NCT04209218","Intraoperative Blood Pressure Management and Dexamethasone in Lung Cancer Surgery","Impact of Intraoperative Blood Pressure Management and Dexamethasone on Patient's Outcomes After Lung Cancer Surgery: A 2 × 2 Factorial Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged \\>50 years but \\\u003C90 years.\n* Diagnosed as resectable primary non-small cell lung cancer (stage IA-IIIA) and scheduled for radical surgery with an expected duration of \\>2 hours.\n* Agree to participate in this study and sign the informed consent.\n\nExclusion Criteria:\n\n* Clinical examinations suggest non-resectable lung cancer or patients scheduled for a biopsy surgery.\n* Recurrent or metastatic lung cancer.\n* History of cancer or complicated with cancer in other organs.\n* Long-term exposure to glucocorticoids or other immunosuppressant(s) due to autoimmune disease or organ transplantation.\n* Uncontrolled hypertension (systolic blood pressure \\>180 mmHg or diastolic blood pressure \\>110 mmHg); or requirement of vasopressors to maintain blood pressure.\n* Persistent atrial fibrillation, or acute cardiovascular events (acute coronary syndrome, stroke, or congestive heart failure) within 3 months.\n* Severe hepatic dysfunction (Child-Pugh C) or renal failure (requirement of renal replacement therapy).\n* Any other circumstances considered unsuitable for study participation by attending physicians or investigators.","ALL","50 Years","90 Years",{"count":101,"type":102},1988,"ESTIMATED","INTERVENTIONAL",[105],"NA","Surgery is the front-line therapy for non-small cell lung cancer (NSCLC) but postoperative complications remains high and patients' long-term outcome is still challenging. In addition to surgery, anesthetic management particularly intraoperative blood pressure management and use of dexamethasone may affect patients' early and long-term outcomes after surgery for NSCLC. This study aims to investigate the impact of intraoperative blood pressure management and dexamethasone administration on early and long-term outcomes in patients undergoing surgery for lung cancer.",[108,109,110,33,111,112],"Lung Cancer","Surgery","Blood Pressure Management","Overall Survival","Postoperative Complications",[108,114,110,33,111,112],"Radical Resection","2025-07-29",{"date":117,"type":118},"2025-07-31","ACTUAL",{"date":120,"type":118},"2020-04-07",{"date":122,"type":102},"2029-12",{"name":5,"class":6},1]