[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589276":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":33,"centralContacts":41,"locations":33,"responsibleParty":45,"collaborators":33,"id":47,"slug":33,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":33,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":33,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":72,"whyStopped":33,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":33},{"fullName":5,"class":6},"Anqing Municipal Hospital","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Intravenous lidocaine","EXPERIMENTAL","Group L received lidocaine 1.5 mg\u002Fkg was injected intravenously 3 min before endotracheal intubation and tracheal spray with 0.8% ropivacaine 40 mg (5 mL) for surface anesthesia",[13],"Drug: Intravenous lidocaine",{"label":15,"type":10,"description":16,"interventionNames":17},"Intracheal dexmedetomidine","Group D received equal volume normal saline was injected intravenously 3 min before tracheal intubation and tracheal spray with dexmedetomidine (1 μg\u002Fkg) mixed with 0.8% ropivacaine 40 mg (5 mL) for surface anesthesia",[18],"Drug: Intracheal dexmedetomidine",{"label":20,"type":10,"description":21,"interventionNames":22},"Intravenous lidocaine combined with intracheal dexmedetomidine","Group LD received lidocaine 1.5 mg\u002Fkg was injected intravenously 3 min before endotracheal intubation and tracheal spray with dexmedetomidine (1 μg\u002Fkg) mixed with 0.8% ropivacaine 40 mg (5 mL) for surface anesthesia",[23],"Drug: Intravenous lidocaine combined with intracheal dexmedetomidine",{"label":25,"type":10,"description":26,"interventionNames":27},"Saline","Group C received equal volume normal saline was injected intravenously 3 min before tracheal intubation and tracheal spray with 0.8% ropivacaine 40 mg (5 mL) for surface anesthesia",[28],"Drug: Saline (NaCl 0,9 %) (placebo)",[30,34,36,38],{"type":31,"name":15,"description":16,"armGroupLabels":32,"otherNames":33},"DRUG",[15],null,{"type":31,"name":9,"description":11,"armGroupLabels":35,"otherNames":33},[9],{"type":31,"name":20,"description":21,"armGroupLabels":37,"otherNames":33},[20],{"type":31,"name":39,"description":26,"armGroupLabels":40,"otherNames":33},"Saline (NaCl 0,9 %) (placebo)",[25],[42],{"name":43,"role":44,"phone":33,"phoneExt":33,"email":33},"Xu Siqi","CONTACT",{"type":46,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100589276",false,"NCT06952309","Intravenous Lidocaine Plus Intratracheal Dexmedetomidine on Postoperative Sore Throat","Effect of Intravenous Lidocaine Combined With Intratracheal Dexmedetomidine on Postoperative Throat Pain in Patients Undergoing Thyroid Cancer Surgery","Inclusion Criteria:\n\n* Thyroid cancer surgery with ASA grades I-II\n* Aged 18-65 years\n* The patient's communication is normal and they have a certain learning ability\n\nExclusion Criteria:\n\n* Severe respiratory and circulatory system diseases\n* There was bradycardia (HR \\\u003C 60 beats\u002Fminute) or atrioventricular block before the operation\n* Nervous system disease\n* Mental and psychological disorders\n* Abnormal liver and kidney functions\n* Pregnant and lactating women","ALL","18 Years","65 Years",{"count":57,"type":58},144,"ESTIMATED","INTERVENTIONAL",[61],"NA","Objective: The present study was to investigate the effect of intravenous lidocaine combined with intratracheal dexmedetomidine on postoperative sore throat in patients undergoing thyroid cancer surgery.\n\nMethods: Investigators enrolled 144 patients with American Society of Anesthesiologists (ASA) physical status I and II, aged 18-65 years, and scheduled for elective undergoing thyroid cancer surgery with general anesthesia. The participants were randomly assigned into four groups(n=36 each group): Group L received lidocaine 1.5 mg\u002Fkg was injected intravenously 3 min before endotracheal intubation and tracheal spray with 0.8% ropivacaine 40 mg (5 mL) for surface anesthesia. Group D received equal volume normal saline was injected intravenously 3 min before tracheal intubation and tracheal spray with dexmedetomidine (1 μg\u002Fkg) mixed with 0.8% ropivacaine 40 mg (5 mL). Group LD received lidocaine 1.5 mg\u002Fkg was injected intravenously 3 min before endotracheal intubation and tracheal spray with dexmedetomidine (1 μg\u002Fkg) mixed with 0.8% ropivacaine 40 mg (5 mL). Group C received equal volume normal saline was injected intravenously 3 min before tracheal intubation and tracheal spray with 0.8% ropivacaine 40 mg (5 mL) for surface anesthesia.The incidence and severity of postoperative sore throat were recorded in four groups at 1 h, 2 h, 6 h, 24 h and 48 h after operation.",[64,65,66],"Dexmedetomidine","Lidocaine","Sore Throat",[68,69,70,71],"dexmedetomidine","lidocaine","thyroid surgery","sore throat","NOT_YET_RECRUITING","2025-04-28",{"date":75,"type":76},"2025-04-30","ACTUAL",{"date":78,"type":58},"2025-04-25",{"date":80,"type":58},"2025-09-25",{"name":5,"class":6}]