Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography
ConditionAcute Heart Failure
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAntonio Leidi
About this trial
The goal of this clinical trial is to investigate whether a lung ultrasonography (LUS)-guided decongestion strategy in adults hospitalized for acute heart failure (AHF) can improve patient-centered outcomes.
The main questions it aims to answer are:
* Does this strategy shorten the length of stay and reduce early hospital readmissions? * Does this strategy improve patients' symptoms and quality of life ?
Researchers will compare LUS to physical examination (PE).
Eligibility criteria
Qualifiers
≥ 18 years old
Planned or actual admission to intermediate care units, general internal medical or cardiology wards
Diagnosis of congestive AHF on admission chart (primary or secondary diagnosis)
Raised value of N terminal-pro-brain natriuretic peptide (≥1000 ng/l).
Disqualifiers
Known isolated right heart failure
Systolic blood pressure <90 mmHg, mean arterial pressure <65 mmHg at the moment of inclusion
The following conditions mimicking lung cardiogenic oedema on LUS if known at inclusion and documented: Interstitial lung disease, lung cancer or metastasis, acute respiratory distress syndrome, pulmonary contusion
Known virologically confirmed SARS-CoV-2 pneumonia in the preceding 3 months
Trial design
Treatments tested in this trial
- LUS decongestive strategy
- PE decongestive strategy
Treatment groups
222 Participants
are divided into 2 treatment groupsLocations
5Geneva University Hospitals1205, GenevaCanton of Geneva, Switzerland
Trois-Chêne Hospital, Geneva Univesity Hospitals1204, GenevaCanton of Geneva, Switzerland
Inselspital, Universitätspital BernSwitzerland, Switzerland
Fribourg University Hospital Fribourg Switzerland
Sponsors and collaborators
Antonio Leidi
Lead sponsor
University Hospital, Geneva
Sponsor institution
University Hospital, Geneva
Collaborator
Source ClinicalTrials.gov