[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100551854":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":31,"responsibleParty":97,"collaborators":101,"id":103,"slug":26,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":104,"sex":110,"minAge":111,"maxAge":26,"enrollmentInfo":112,"targetDuration":26,"studyType":115,"phases":116,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":34,"whyStopped":26,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},{"fullName":5,"class":6},"University Hospital, Geneva","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Lung ultrasonography (LUS)","EXPERIMENTAL","The antero-lateral thorax is examined using an 8-point protocol. Each region is coded positive in presence of ≥3 B-lines simultaneously on a frozen image or in presence of significant pleural effusion (i.e. extending over the costophrenic angle). A 4-level congestion score is defined: absence of congestion (0-1 positive points), mild congestion (2-3 positive points), moderate congestion (4-5 positive points) and severe congestion (6-8 positive points).",[13],"Procedure: LUS decongestive strategy",{"label":15,"type":16,"description":17,"interventionNames":18},"Physical Examination (PE)","ACTIVE_COMPARATOR","Congestion is clinically assessed by calculating the Everest score. This score, previously used in clinical trials, is composed of 3 congestion symptoms (i.e. dyspnea, orthopnoea and fatigue) and 3 congestion signs (i.e. jugular vein distension, lung rales, oedema), each graded from 0 to 3. From the total score, a sub-score is derived, ranging from absence of congestion to severe congestion.",[19],"Procedure: PE decongestive strategy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","LUS decongestive strategy","LUS results are documented in the electronic case report form (eCRF) and converted into a common score ranging from absence of congestion to severe congestion. This generic congestion score will be communicated to the treating physician by the research personnel, along with a proposal to step-up, maintain, or step-down the decongestive therapy.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"PE decongestive strategy","PE results are documented in the eCRF and converted into a common score ranging from absence of congestion to severe congestion. This generic congestion score will be communicated to the treating physician by the research personnel, along with a proposal to step-up, maintain, or step-down the decongestive therapy.",[15],[32,51,62,75,88],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Trois-Chêne Hospital, Geneva Univesity Hospitals","RECRUITING","Geneva","Canton of Geneva","1204","Switzerland",{"type":40,"coordinates":41},"Point",[42,43],6.14569,46.20222,{"lat":43,"lon":42},[46],{"name":47,"role":48,"phone":49,"phoneExt":26,"email":50},"Thibault Parent, Dr","CONTACT","+41 79 55 38 856","thibault.parent@hug.ch",{"facility":52,"status":34,"city":35,"state":36,"zip":53,"country":38,"cosmosGeoPoint":54,"geoPoint":56,"contacts":57},"Geneva University Hospitals","1205",{"type":40,"coordinates":55},[42,43],{"lat":43,"lon":42},[58],{"name":59,"role":48,"phone":60,"phoneExt":26,"email":61},"Antonio Leidi, MD","+41223729101","Antonio.Leidi@hug.ch",{"facility":63,"status":34,"city":64,"state":38,"zip":26,"country":38,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Inselspital, Universitätspital","Bern",{"type":40,"coordinates":66},[67,68],7.44744,46.94809,{"lat":68,"lon":67},[71],{"name":72,"role":48,"phone":73,"phoneExt":26,"email":74},"Claudio Schneider","+41 31 632 21 11","claudio.schneider@insel.ch",{"facility":76,"status":34,"city":77,"state":26,"zip":26,"country":38,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Fribourg University Hospital","Fribourg",{"type":40,"coordinates":79},[80,81],7.15128,46.80237,{"lat":81,"lon":80},[84],{"name":85,"role":48,"phone":86,"phoneExt":26,"email":87},"Fernando Esposito","+41 26 306 23 64","Fernando.Esposito@hfr.ch",{"facility":89,"status":90,"city":91,"state":26,"zip":26,"country":38,"cosmosGeoPoint":92,"geoPoint":96,"contacts":26},"Ospedale Civico, Ente Ospedaliero Cantonale","TERMINATED","Lugano",{"type":40,"coordinates":93},[94,95],8.96004,46.01008,{"lat":95,"lon":94},{"type":98,"investigatorFullName":99,"investigatorTitle":100,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Antonio Leidi","M.D., Principal Investigator, Attending physician in Internal and Emergency Medicine Services",[102],{"name":5,"class":6},"100551854",false,"NCT06465498","Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography","Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography (IcarUS) : a Randomized Controlled Trial","IcarUS","Inclusion Criteria:\n\n* ≥ 18 years old\n* Planned or actual admission to intermediate care units, general internal medical or cardiology wards\n* Diagnosis of congestive AHF on admission chart (primary or secondary diagnosis)\n* Raised value of N terminal-pro-brain natriuretic peptide (≥1000 ng\u002Fl).\n\nKey Exclusion Criteria:\n\n* Known isolated right heart failure\n* Systolic blood pressure \\\u003C90 mmHg, mean arterial pressure \\\u003C65 mmHg at the moment of inclusion\n* The following conditions mimicking lung cardiogenic oedema on LUS if known at inclusion and documented: Interstitial lung disease, lung cancer or metastasis, acute respiratory distress syndrome, pulmonary contusion\n* Known virologically confirmed SARS-CoV-2 pneumonia in the preceding 3 months\n* Unwillingness to give consent\n* Subjects who are pregnant or breastfeeding\n* Hospitalisation for palliative care and probable end-life within 30 days","ALL","18 Years",{"count":113,"type":114},222,"ESTIMATED","INTERVENTIONAL",[117],"NA","The goal of this clinical trial is to investigate whether a lung ultrasonography (LUS)-guided decongestion strategy in adults hospitalized for acute heart failure (AHF) can improve patient-centered outcomes.\n\nThe main questions it aims to answer are:\n\n* Does this strategy shorten the length of stay and reduce early hospital readmissions?\n* Does this strategy improve patients' symptoms and quality of life ?\n\nResearchers will compare LUS to physical examination (PE).",[120],"Acute Heart Failure",[122,123,124,125,126],"Lung ultrasonography","Ultrasound","Point-of-care ultrasonography","Decongestion","Diuretic","2026-03-26",{"date":129,"type":130},"2026-04-01","ACTUAL",{"date":132,"type":130},"2024-10-22",{"date":134,"type":114},"2027-04-30",{"name":99,"class":6},5]