[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100484695":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":51,"collaborators":53,"id":56,"slug":18,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":18,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":37,"whyStopped":18,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Massachusetts Institute of Technology","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Film + TSST","EXPERIMENTAL","Nature Film + Trier Social Stress Test (TSST)",[13],"Behavioral: Trier Social Stress Test (TSST)",{"label":15,"type":16,"description":17,"interventionNames":18},"Film Only (No-TSST)","NO_INTERVENTION","Nature Film Only",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Trier Social Stress Test (TSST)","Participants randomized to the TSST arm will experience the Trier Social Stress Test.",[9],[26],{"name":27,"affiliation":5,"role":28},"John Gabrieli, PhD","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Omar Rutledge, MS","CONTACT","617-324-2898","orutledge@mit.edu",[36],{"facility":5,"status":37,"city":38,"state":39,"zip":40,"country":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Cambridge","Massachusetts","02139","United States",{"type":43,"coordinates":44},"Point",[45,46],-71.10561,42.3751,{"lat":46,"lon":45},[49,50],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},{"name":27,"role":28,"phone":18,"phoneExt":18,"email":18},{"type":52,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[54],{"name":55,"class":6},"Massachusetts General Hospital","100484695",false,"NCT05591404","Investigating the Effects of Social Stress on Brain Imaging","SSBI","Inclusion Criteria:\n\n* Ability and willingness to provide written informed consent.\n* Sufficiently fluent in English to participate in the trial.\n* Between 18-55 years of age (inclusive).\n* Right-hand dominant.\n* Current medications are stable for past 30 days (no changes to dose or frequency).\n* Negative result on pregnancy test (if female).\n* Negative result on urine drug screening.\n* Liebowitz Social Anxiety Scale (LSAS \\\u003C30).\n\nExclusion Criteria:\n\n* History of bipolar disorder, schizophrenia, psychosis, delusional disorders.\n* History of eating disorder within past 6 months.\n* History of any traumatic brain injury.\n* Currently diagnosed with diabetes mellitus.\n* Presence of severe medical illness that would prevent completion of study procedures.\n* Presence of significant neurological illness or cognitive dysfunction (e.g.; seizures, dementia).\n* History of substance use disorder within past 6 months (other than nicotine and caffeine).\n* Use of any cannabis-containing products in past 30 days (CBD or THC).\n* Use of benzodiazepines in past 2 weeks.\n* Use of alpha- or beta-blockers in the past week.\n* History of claustrophobia.\n* Contraindications for MRI (e.g.; shrapnel).\n* Presence of any other medical condition that, in the investigator's opinion, may interfere with the study procedures.",true,"ALL","18 Years","55 Years",{"count":67,"type":68},50,"ESTIMATED","INTERVENTIONAL",[71],"NA","The purpose of this study is to examine whether experiencing a social stressor prior to the collection of neuroimaging measures is associated with differences in brain activation in healthy participants.",[74],"Social Stress",[74,76],"fMRI","2025-11-25",{"date":79,"type":80},"2025-12-03","ACTUAL",{"date":82,"type":80},"2025-11-17",{"date":84,"type":68},"2026-11",{"name":5,"class":6},1]