[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643622":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":26,"id":57,"slug":26,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":26,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":26,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Tianjin Anding Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"active","ACTIVE_COMPARATOR","The peak-to-peak amplitude was 1 mA at 40 Hz (tACS), with a frequency and a sinusoidal stimulation waveform. The stimulation sites were located in the prefrontal cortex (F3 and F4) based on the 10-20 international EEG electrode placement system, with CZ serving as the return electrode.",[13],"Device: Transcranial Alternating Current Stimulation (tACS)",{"label":15,"type":16,"description":17,"interventionNames":18},"shame","SHAM_COMPARATOR","The peak-to-peak amplitude was 1 mA at 40 Hz (tACS), with a frequency and a sinusoidal stimulation waveform. The stimulation sites were located in the prefrontal cortex (F3 and F4) based on the 10-20 international EEG electrode placement system, with CZ serving as the return electrode, shame arm is not biologically active.",[19],"Device: shame tACS",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Transcranial Alternating Current Stimulation (tACS)","divided into a real-stimulus group and a sham-stimulus group",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"shame tACS","The sham tACS group received 40 Hz tACS with a peak-to-peak amplitude of 1 mA, a frequency of y, and a sinusoidal waveform. The stimulation sites were located in the prefrontal cortex (F3 and F4) based on the 10-20 system of international EEG electrode placement, with CZ serving as the return electrode, which did not generate stimulation pulses.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Daliang Sun Da liang Sun, Doctor","CONTACT","+86 88188876","474929588@qq.com",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Tianjin","Tianjin Municipality","300222","China",{"type":45,"coordinates":46},"Point",[47,48],117.17667,39.14222,{"lat":48,"lon":47},[51],{"name":52,"role":34,"phone":35,"phoneExt":26,"email":36},"Daliang Sun, Doctor",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Jie Li","Chief psychiatrist","100643622",false,"NCT07637773","Investigating the Efficacy and Mechanisms of Individualized tACS Targeting Anhedonia in Late-Life Depression","Efficacy and Mechanisms of Personalized tACS Targeting Anhedonia in Late-Life Depression","Inclusion Criteria:\n\n* (1) Patients were interviewed using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) - Clinical Version (SCID-5-CV) to confirm that they met the DSM-5 diagnostic criteria for \"major depressive disorder\"; (2) Age ≥ 60 years; gender not restricted; (3) Hamilton Depression Scale (HAMD)-17 score \\> 24\n\nExclusion Criteria:\n\n\\- (1) History of severe head trauma or serious neurological conditions such as epilepsy; (2) Any brain devices or implants, including cochlear implants and aneurysm clips; treatments such as transcranial direct current stimulation (tDCS).\n\n(3) Individuals who have undergone other physical modulation therapies within the past 8 weeks, including but not limited to non-convulsive electroconvulsive therapy, repetitive transcranial magnetic stimulation, and transcranial direct current stimulation.","ALL","60 Years",{"count":66,"type":67},80,"ESTIMATED","INTERVENTIONAL",[70],"NA","This project focuses on clinical translational research into personalized transcranial alternating current stimulation (tACS) for treating anhedonia in late-life depression (LLD). Key components include: (1) Optimizing individualized tACS treatment parameters through randomized, double-blind, controlled trials and establishing precise treatment protocols using deep learning algorithms; (2) Assessing the short-term (2 weeks) and long-term (3 months) efficacy of tACS on depressive symptoms and anhedonia using scales such as the HAMD, SHAPS, and DARS, while monitoring safety; (3) Integrating multimodal detection technologies (64-channel EEG, inflammatory factors\u002Fneurotransmitters, etc.) to elucidate the mechanisms by which tACS alleviates anhedonia through modulating prefrontal neural oscillations (y-band), improving synaptic plasticity (increased BDNF), and regulating neurotransmitters (5-HT, DA). This study will establish, for the first time, an individualized parameter system for tACS treatment of LLD, providing a novel non-pharmacological intervention strategy for clinical practice.",[73,74],"Late-Life Depression","Anhedonia",[76,77,78,79],"transcranial alternating current stimulation","late-life depression","anhedonia","Brain function","2026-06-09",{"date":82,"type":83},"2026-06-10","ACTUAL",{"date":85,"type":83},"2026-03-16",{"date":87,"type":67},"2027-12-31",{"name":55,"class":6},1]