Fibromyalgia is characterized by altered pain processing, including impaired descending pain inhibition and central sensitization. While both mechanisms have been independently associated with disease severity, their interrelationship remains unclear. This cross-sectional study aims to investigate whether central sensitization symptoms mediate the relationship between conditioned pain modulation and fibromyalgia impact.
Having received a diagnosis of fibromyalgia according to the 2016 ACR diagnostic criteria
Female patients aged 18-65
Being literate
Having signed the informed consent form upon agreeing to participate in the study
Being under 18 or over 65 years of age
Having any condition that may lower the pain threshold or cause chronic pain (Rheumatoid Arthritis, Ankylosing Spondylitis, systemic inflammatory diseases, malignancies, etc.)
Any neurological condition (stroke, traumatic brain injury, multiple sclerosis, Parkinson's disease, central nervous system malignancies…)
Peripheral artery disease
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Lead sponsor