[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574960":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":18,"responsibleParty":53,"collaborators":7,"id":55,"slug":7,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":7,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":67,"studyType":68,"phases":7,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Texas A&M University","OTHER",null,[9,14],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Kenneth S Ramos,, MD","CONTACT","7136777740","kramos@tamu.edu",{"name":15,"role":11,"phone":16,"phoneExt":7,"email":17},"Rick Silva, PhD","(713) 677-7422","ricksilva@tamu.edu",[19],{"facility":20,"status":21,"city":22,"state":23,"zip":24,"country":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"Texas A&M Family Care","RECRUITING","Bryan","Texas","77802","United States",{"type":27,"coordinates":28},"Point",[29,30],-96.36996,30.67436,{"lat":30,"lon":29},[33,37,41,44,46,47,49,51],{"name":34,"role":11,"phone":35,"phoneExt":7,"email":36},"Gabriel Neal, MD","979-436-0399","gneal@tamu.edu",{"name":38,"role":11,"phone":39,"phoneExt":7,"email":40},"Sara Rogers, PharmD","979 436 0286","sararogers@tamu.edu",{"name":42,"role":43,"phone":7,"phoneExt":7,"email":7},"Kenneth S Ramos, MD, PhD","PRINCIPAL_INVESTIGATOR",{"name":15,"role":45,"phone":7,"phoneExt":7,"email":7},"SUB_INVESTIGATOR",{"name":38,"role":45,"phone":7,"phoneExt":7,"email":7},{"name":48,"role":45,"phone":7,"phoneExt":7,"email":7},"George Udeani, PharmD",{"name":50,"role":45,"phone":7,"phoneExt":7,"email":7},"Fen Wang, PhD",{"name":52,"role":45,"phone":7,"phoneExt":7,"email":7},"Marcia Ory, PhD",{"type":54,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100574960",false,"NCT06766071","IPGx PILOT Whole Genome Sequencing Extension Cohort","The Texas A&M Interprofessional Pharmacogenomics PILOT Whole Genome Sequencing (WGS) Cohort","Inclusion Criteria:\n\n* Individuals taking 5 or more medications, including over the counter drugs, supplements, natural products, cannabis produces, or other recreational drugs.\n* Ability to give and comprehend the consent process.\n* Consent to donate urine samples, genetic data through buccal swabs and blood samples, and undergo a comprehensive history and physical examination.\n* All genders\n* Age 18-100\n\nExclusion Criteria:\n\n* Subject has been diagnosed or is being treated for any cancer other than basal cell cancer in the last 5 years. Patients with metastatic melanoma in the last 5 years will be excluded.\n* Admitted to hospice.\n* Patient has ever been diagnosed with Hepatitis B or C.\n* Patient has ever been diagnosed with active liver disease, hepatomegaly, grossly abnormal liver function. Meld score \\>10, ALT, or AST \\>100U\u002FL or an AST\u002FALT ratio \\>2\n* Patients taking imidazole antifungal medication.\n* Declines to participate or interact with staff\u002Fshare their medical status.\n* A diagnosis of Alzheimer's disease or related dementias in a medical record indicates a progressive, debilitating condition that impairs memory, thought processes, and functioning.\n* Pregnant patients will be excluded.\n* Individuals who are unable or unwilling to provide consent will be excluded.\n* Unable to verbally communicate and comprehend English language.","ALL","18 Years","100 Years",{"count":65,"type":66},50,"ESTIMATED","180 Days","OBSERVATIONAL","The investigator's primary aim is to evaluate polypharmacy-associated adverse drug reactions (ADR) in a pilot study of at-risk patients using state-of-the-art pharmacogenomic technology and to use this information to make recommendations for optimization of pharmacotherapy regimens. The data from the pilot cohort will be used to optimize and integrate a customized electronic decision support (clinical semantic network; CSN) dashboard to identify drug regimens that should be modified, replaced, or discontinued. A secondary objective of the pilot study is to evaluate the capacity\u002Fsaturation of CYP P450 enzymatic pathways in polypharmacy patients. A third objective is to determine the feasibility of the planned informatics workflows between the CLIA lab, the EMR, and the Family Medicine Practice including Whole Genome Sequencing (WGS).",[71,72],"Adverse Drug Reaction (ADR)","Polypharmacy Patients",[74],"whole genome sequencing","2025-01-03",{"date":77,"type":78},"2025-01-09","ACTUAL",{"date":80,"type":66},"2025-01",{"date":82,"type":66},"2026-01",{"name":5,"class":6},1]