[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605901":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":39,"collaborators":10,"id":43,"slug":10,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":10,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":10,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":10,"overallStatus":62,"whyStopped":10,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8,16,20],{"label":9,"type":10,"description":11,"interventionNames":12},"1- obese +-nafld+- fibrosis",null,"Obese patients with non alcoholic fatty liver disease with fibrosis",[13,14,15],"Diagnostic Test: *Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .","Radiation: *Imaging Studies:* 1- Ultrasound 2 - FibroScan","Device: Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.",{"label":17,"type":10,"description":18,"interventionNames":19},"obese +- hyperuricemia +- nfld+- fibrosis","Obese patients with hyperuricemia and non alcoholic liver disease and fibrosis",[13,14,15],{"label":21,"type":10,"description":21,"interventionNames":22},"Healthy controls",[13,14,15],[24,29,34],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"DIAGNOSTIC_TEST","*Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .","Lab methods",[9,21,17],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"RADIATION","*Imaging Studies:* 1- Ultrasound 2 - FibroScan","Imaging",[9,21,17],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":10},"DEVICE","Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.","Instrument",[9,21,17],{"type":40,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Aya Adel Mahmoud Abu Shady","Internal medicine Resident doctor","100605901",false,"NCT07168551","Is There a Relationship Between Uric Acid Level and Liver Fibrosis in Obese Patients","Association of Hyperuricemia and Non Alcoholic Fatty Liver Disease and Liver Fibrosis Risk in Adult Obese Patients","Inclusion Criteria:\n\n1. Age: Adults (typically 18-65 years old)\n\n2 - Body Mass Index (BMI): Obese patients with a BMI ≥ 30 kg\u002Fm²\n\n3- Hyperuricemia : Elevated serum uric acid levels (typically \\> 7 mg\u002FdL for men and \\> 6 mg\u002FdL for women)\n\nExclusion Criteria:\n\n* excessive alcohol consumption ( \\> 20 gm \u002Fday in men and 10 in g \u002Fday in women )\n\n  2- use of steatogenic within the past 6 months\n\n  3- positive test for hepatitis B surface antigen and hepatitis B core antibody\n\n  4- Drug induced liver injury and autoimmune hepatitis\n\n  5 - cirrhosis and other causes of liver disease",true,"ALL","18 Years","65 Years",{"count":54,"type":55},111,"ESTIMATED","OBSERVATIONAL","1. Identifying the association between hyperuricemia and NAFLD can lead to early detection and prevention of liver fibrosis in adult obese patients.\n2. Understanding the relationship between hyperuricemia and NAFLD can inform targeted therapy, such as urate-lowering treatment, to potentially slow disease progression.\n\n3 - To examine the relationship between serum uric acid levels and liver fibrosis severity\\*: Assessing the correlation between serum uric acid levels and the severity of liver fibrosis in adult obese patients with NAFLD.\n\n4- To identify potential mechanisms underlying the association\\*: Exploring the potential mechanisms by which hyperuricemia may contribute to the development and progression of NAFLD and liver fibrosis in adult obese patients.",[59,60,61],"Hyperuricemia","NAFLD (Nonalcoholic Fatty Liver Disease)","Liver Fibrosis","NOT_YET_RECRUITING","2025-09-12",{"date":65,"type":66},"2025-09-15","ACTUAL",{"date":68,"type":55},"2025-10-01",{"date":70,"type":55},"2026-12-01",{"name":5,"class":6}]