[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633930":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":25,"locations":34,"responsibleParty":215,"collaborators":217,"id":238,"slug":10,"hasResults":239,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":10,"eligibilityCriteria":243,"healthyVolunteers":244,"sex":245,"minAge":246,"maxAge":10,"enrollmentInfo":247,"targetDuration":250,"studyType":251,"phases":10,"briefSummary":252,"conditions":253,"keywords":261,"overallStatus":275,"whyStopped":10,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":285},{"fullName":5,"class":6},"Neuromed IRCCS","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"HC",null,"Healthy older adults (HC) aged ≥ 65 years residing in Italy. No diagnosis of depression, mild cognitive impairment or any form of dementia.",{"label":13,"type":10,"description":14,"interventionNames":10},"SMC","Older adults with subjective memory complaints (SMC) aged ≥65 years, residing in Italy, who report or perceive subjective memory decline. This subjective memory complaint may occur with or without objective evidence of memory impairment and may be reported by the individual, a family member, or a clinician. Individuals with SMC should be excluded if they have a diagnosis of depression, mild cognitive impairment, or any form of dementia.",{"label":16,"type":10,"description":17,"interventionNames":10},"MCI","Older adults diagnosed with mild cognitive impairment (MCI), aged ≥65 years and residing in Italy, characterized by subjective cognitive decline (reported by the individual, a family member, or a clinician), objective cognitive impairment (as assessed by the Wechsler Memory Scale Logical Memory II), and relatively preserved activities of daily living. Individuals with MCI should be excluded if they have a diagnosis of depression or any form of dementia.",{"label":19,"type":10,"description":20,"interventionNames":10},"AD","Older adults diagnosed with probable Alzheimer's disease (AD), aged ≥65 years, residing in Italy. Individuals with probable AD exhibit a decline in performance compared to their previous level of functioning, as reported by a caregiver (often a family member), along with objective evidence of episodic memory impairment on the Wechsler Memory Scale Logical Memory II.",[22],{"name":23,"affiliation":5,"role":24},"Luana Dr Gilio","PRINCIPAL_INVESTIGATOR",[26,30],{"name":23,"role":27,"phone":28,"phoneExt":10,"email":29},"CONTACT","+393404757480","gilio.luana@gmail.com",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"Direzione Scientifica IRCCS Neuromed","+390865915217","direzionescientifica@neuromed.it",[35,62,84,103,127,146,168,191],{"facility":36,"status":10,"city":37,"state":38,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"IRCCS Centro San Giovanni di Dio Fatebenefratelli","Brescia","BS","25125","Italy",{"type":42,"coordinates":43},"Point",[44,45],10.21472,45.53558,{"lat":45,"lon":44},[48,52,55,57,60],{"name":49,"role":27,"phone":50,"phoneExt":10,"email":51},"Cristina Dr Festari","+39 030 3501335","cfestari@fatebenefratelli.eu",{"name":53,"role":27,"phone":10,"phoneExt":10,"email":54},"Michela Dr Pievani","mpievani@fatebenefratelli.eu",{"name":56,"role":24,"phone":10,"phoneExt":10,"email":10},"Cristina Festari",{"name":58,"role":59,"phone":10,"phoneExt":10,"email":10},"Michela Pievani","SUB_INVESTIGATOR",{"name":61,"role":59,"phone":10,"phoneExt":10,"email":10},"Claudio Singh Solorzano",{"facility":63,"status":10,"city":64,"state":65,"zip":66,"country":40,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"IRCCS San Martino","Genova","GE","16132",{"type":42,"coordinates":68},[69,70],11.87211,45.21604,{"lat":70,"lon":69},[73,77,80,82],{"name":74,"role":27,"phone":75,"phoneExt":10,"email":76},"Antonio Dr Uccelli","+390105558722","direzione.scientifica@hsanmartino.it",{"name":78,"role":27,"phone":10,"phoneExt":10,"email":79},"Matteo Dr Pardini","matteo.pardini@gmail.com",{"name":81,"role":24,"phone":10,"phoneExt":10,"email":10},"Antonio Uccelli",{"name":83,"role":59,"phone":10,"phoneExt":10,"email":10},"Matteo Pardini",{"facility":85,"status":10,"city":86,"state":87,"zip":88,"country":40,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"IRCCS Neuromed - Istituto Neurologico Mediterraneo","Pozzilli","IS","86077",{"type":42,"coordinates":90},[91,92],14.06252,41.51142,{"lat":92,"lon":91},[95,96,97,99,101],{"name":23,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},{"name":98,"role":24,"phone":10,"phoneExt":10,"email":10},"Luana Gilio",{"name":100,"role":59,"phone":10,"phoneExt":10,"email":10},"Giovanni Galifi",{"name":102,"role":59,"phone":10,"phoneExt":10,"email":10},"Vanessa Pipino",{"facility":104,"status":10,"city":105,"state":106,"zip":107,"country":40,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"IRCCS Ospedale San Raffaele","Milan","Michigan","20132",{"type":42,"coordinates":109},[110,111],12.59836,42.78235,{"lat":111,"lon":110},[114,118,121,123,125],{"name":115,"role":27,"phone":116,"phoneExt":10,"email":117},"Massimo Dr Filippi","+390226433958","filippi.massimo@hsr.it",{"name":119,"role":27,"phone":10,"phoneExt":10,"email":120},"Federica Dr Agosta","agosta.federica@hsr.it",{"name":122,"role":24,"phone":10,"phoneExt":10,"email":10},"Massimo Filippi",{"name":124,"role":59,"phone":10,"phoneExt":10,"email":10},"Federica Agosta",{"name":126,"role":59,"phone":10,"phoneExt":10,"email":10},"Elisa Canu",{"facility":128,"status":10,"city":105,"state":106,"zip":129,"country":40,"cosmosGeoPoint":130,"geoPoint":132,"contacts":133},"IRCCS Istituto Neurologico Carlo Besta","20133",{"type":42,"coordinates":131},[110,111],{"lat":111,"lon":110},[134,138,142,144],{"name":135,"role":27,"phone":136,"phoneExt":10,"email":137},"Giuseppe Dr Lauria-Pinter","+390223942243","giuseppe.lauriapinter@istituto-besta.it",{"name":139,"role":27,"phone":140,"phoneExt":10,"email":141},"Monica Dr Consonni","+390223942366","monica.consonni@istituto-besta.it",{"name":143,"role":24,"phone":10,"phoneExt":10,"email":10},"Giuseppe Lauria-Pinter",{"name":145,"role":59,"phone":10,"phoneExt":10,"email":10},"Monica Consonni",{"facility":147,"status":10,"city":148,"state":149,"zip":150,"country":40,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"IRCCS Fondazione Mondino","Pavia","PV","27100",{"type":42,"coordinates":152},[153,154],9.15917,45.19205,{"lat":154,"lon":153},[157,161,164,166],{"name":158,"role":27,"phone":159,"phoneExt":10,"email":160},"Alfredo Dr Costa","+390382380343","alfredo.costa@unipv.it",{"name":162,"role":27,"phone":10,"phoneExt":10,"email":163},"Valentino Dr De Franco","valentino.defranco@mondino.it",{"name":165,"role":24,"phone":10,"phoneExt":10,"email":10},"Alfredo Costa",{"name":167,"role":59,"phone":10,"phoneExt":10,"email":10},"Valentino De Franco",{"facility":169,"status":10,"city":170,"state":171,"zip":172,"country":40,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"IRCCS Campus Bio-Medico","Roma","RM","00128",{"type":42,"coordinates":174},[175,176],11.10642,44.99364,{"lat":176,"lon":175},[179,183,187,189],{"name":180,"role":27,"phone":181,"phoneExt":10,"email":182},"Vincenzo Dr Di Lazzaro","+39 06 22541 1220","v.dilazzaro@policlinicocampus.it",{"name":184,"role":27,"phone":185,"phoneExt":10,"email":186},"Francesco Dr Motolese","+39 06 22541 1447","f.motolese@policlinicocampus.it",{"name":188,"role":24,"phone":10,"phoneExt":10,"email":10},"Vincenzo Di Lazzaro",{"name":190,"role":59,"phone":10,"phoneExt":10,"email":10},"Francesco Motolese",{"facility":192,"status":10,"city":193,"state":194,"zip":195,"country":40,"cosmosGeoPoint":196,"geoPoint":200,"contacts":201},"IRCCS Ospedale San Camillo","Venezia","VE","30126",{"type":42,"coordinates":197},[198,199],11.17365,44.42329,{"lat":199,"lon":198},[202,206,209,211,213],{"name":203,"role":27,"phone":204,"phoneExt":10,"email":205},"Giorgio Dr Arcara","+390412207594","giorgio.arcara@hsancamillo.it",{"name":207,"role":27,"phone":10,"phoneExt":10,"email":208},"Rachele Dr Pezzetta","rachele.pezzetta@hsancamillo.it",{"name":210,"role":24,"phone":10,"phoneExt":10,"email":10},"Giorgio Arcara",{"name":212,"role":59,"phone":10,"phoneExt":10,"email":10},"Rachele Pezzetta",{"name":214,"role":59,"phone":10,"phoneExt":10,"email":10},"Cristina Scarpazza",{"type":24,"investigatorFullName":98,"investigatorTitle":216,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Psychologist, Psychotherapist, PhD, Researcher in Neuropsychology and Cognitive Neuroscience",[218,221,223,225,227,228,230,232,234,236],{"name":219,"class":220},"Istituto ricerca carattere Scientifico Fatebenefratelli Brescia","UNKNOWN",{"name":222,"class":6},"IRCCS National Neurological Institute \"C. Mondino\" Foundation",{"name":224,"class":6},"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta",{"name":226,"class":6},"IRCCS San Camillo, Venezia, Italy",{"name":104,"class":6},{"name":229,"class":220},"Campus Biomedico - Roma",{"name":231,"class":6},"IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy",{"name":233,"class":6},"Università degli Studi 'G. d'Annunzio' Chieti e Pescara",{"name":235,"class":6},"University of Foggia",{"name":237,"class":6},"University of Padova","100633930",false,"NCT07533084","Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables","Italian Validation of the Dynamic Neurocognitive Adaptation (dNA) Scale and Its Correlation With Neurocognitive Variables","Inclusion Criteria (Stage #1):\n\n* Individuals aged ≥ 65 years residing in Italy;\n* Cognitively healthy individuals (HC);\n* Individuals with subjective memory complaints (SMC);\n* Individuals with mild cognitive impairment (MCI);\n* Individuals with probable Alzheimer's disease (AD).\n\nInclusion criteria (Stage #2 \\& Stage #3):\n\n* Individuals aged ≥ 65 years residing in Italy;\n* Cognitively healthy individuals (HC);\n* Individuals with subjective memory complaints (SMC);\n* Individuals with mild cognitive impairment (MCI);\n* Individuals with probable Alzheimer's disease (AD);\n* Individuals with Alzheimer's disease or other forms of dementia;\n* Individuals suffering from mental disorders clinically diagnosed.\n\nCognitively healthy individuals (HC):\n\n* MMSE score ≥24, or alternatively MoCA score ≥26;\n* No diagnosis of depression, MCI or any form of dementia;\n* Episodic memory performance within the normal range (Wechsler Memory Scale Logical Memory II ≥9 for 16 years of schooling or more; ≥5 for 8-15 years of schooling, ≥3 for 0-7 years of schooling; or alternatively for Prose Memory Test with scores ≥9 for ≥16 years of schooling → ≥5 items in immediate or delayed recall; ≥5 for 8-15 years of schooling → ≥3-4 items in immediate or delayed recall; ≥3 for 0-7 years of schooling → ≥2 items in immediate or delayed recall)\n\nIndividuals with Subjective Memory Complaints (SMC):\n\n* MMSE score ≥24, or alternatively MoCA score ≥26;\n* A significant memory impairment, reported by the subject, a family member, or the clinician;\n* No diagnosis of depression, MCI or any form of dementia;\n* Episodic memory performance within the normal range on the Wechsler Memory Scale Logical Memory II adjusted for years of schooling (≥9 for 16+ years of schooling, ≥5 for 8-15 years of schooling, ≥3 for 0-7 years of schooling) or, alternatively, on the Prose Memory Test (with scores ≥9 for ≥16 years of schooling → ≥5 items in immediate or delayed recall; ≥5 for 8-15 years of schooling → ≥3-4 items in immediate or delayed recall; ≥3 for 0-7 years of schooling → ≥2 items in immediate or delayed recall)\n\nIndividuals with Mild Cognitive Impairment (MCI):\n\n* MMSE score between 19 and 23 inclusive (alternatively MoCA);\n* A decline in memory reported by the subject, a family member, or the clinician;\n* No diagnosis of depression or affected by any form of dementia, with preserved ability in activities of daily living;\n* Objective episodic memory loss on the Wechsler Memory Scale Logical Memory II adjusted for years of schooling.\n\nIndividuals with probable Alzheimer's disease (AD):\n\n* Insidious onset with atypical course: some criteria for probable AD are met, but the onset of symptoms may have been sudden, or there is a lack of objective evidence of progressive cognitive decline;\n* Mixed etiology presentation: All criteria for probable AD are met, with concomitant cerebrovascular disorders, or the presence of features typical of another dementia or the evidence of other neurological disorders or non-neurological comorbidities;\n* A decline in performance compared to the previous level of functioning is evident, as also described by a caregiver (often a family member)\n* Onset with memory disturbances, defined as difficulty learning new information or recalling it;\n* Onset with non-mnemonic symptoms (language symptoms, particularly difficulty finding the correct words; visuospatial symptoms: perceptual deficits characterized by failure to recognize objects, people, or written words; executive symptoms: difficulties with reasoning and critical thinking);\n* MMSE score \\\u003C 23 (alternatively MoCA \\\u003C 25);\n* Objective episodic memory loss on the Wechsler Memory Scale Logical Memory II adjusted for years of schooling.\n\nExclusion criteria (Stage #1):\n\n* Individuals aged \\\u003C 65 years;\n* Individuals not residing in Italy;\n* Individuals with depression or other psychiatric disorders;\n* Individuals with forms of dementia other than Alzheimer's disease.",true,"ALL","65 Years",{"count":248,"type":249},265,"ESTIMATED","1 Year","OBSERVATIONAL","The goal of this experimental multicentric intervention study is to validate, in Italian, the dynamic Neurocognitive Adaptation (dNA) Scale, which has already been validated in English, among a healthy elderly population (aged 65 and older) residing in Italy and patients with dementia or Alzheimer's Disease. dNA is a questionnaire designed to assess both current and past levels of engagement in physical, cognitive, creative, and social activities.\n\nThe study aims to recruit a total of 265 participants with mild cognitive impairment, subjective memory complaints, or dementia. These participants will be distributed among the 8 recruitment centers. Neuropsychological data, subjective measures, and MRI data will be collected and analyzed to address the following research questions: 1) Is there a positive correlation between scores on the dNA Scale and cognitive efficiency, as reflected in neuropsychological measures, such as episodic memory and executive functions? 2) Is there a correlation between dNA scores and improved functional connectivity within neural networks, such as the Default Network (DN)?\n\nParticipants recruited at the participating clinical centers will undergo:\n\n* A clinical interview, during which demographic and medical history information will be collected. The dNA Scale will be administered, along with a questionnaire assessing adherence to dietary habits typical of a Mediterranean diet (14-Item Mediterranean Diet Adherence Screener; MEDAS).\n* A neuropsychological assessment, aimed at evaluating general cognitive function with a particular focus on episodic memory and executive functions. The following tests will be administered: Mini-Mental State Examination (MMSE) or, alternatively, Montreal Cognitive Assessment (MoCA); Rey Auditory Verbal Learning Test (RAVLT); Trial Making Test (TMT) Form B; Digit Span Forward and Backward (WAIS or WAIS-III); and the Stroop Test.\n* Self-report questionnaires designed to assess depressive symptoms using the Geriatric Depression Scale (GDS) and anxiety symptoms using the Geriatric Anxiety Scale (GAS) (or alternatively the State-Trait Anxiety Inventory, STAI). Finally, the Cognitive Reserve Index Questionnaire will be administered to estimate Cognitive Reserve (CRIq).\n* Where available, MRI data previously acquired for clinical or diagnostic purposes will be included in the study and analyzed by the principal investigator.",[254,255,256,257,258,259,260],"Active Aging Individuals Aged 65 and Over","Aging","Mild Cognitive Impairment (MCI)","Dementia","Dementia Alzheimer Type","Subjective Memory Complaints","Probable Alzheimer's Disease",[262,263,264,265,266,267,268,269,270,271,272,273,274],"activities","habits","lifetime protective factors","adaptation","dynamic","neurocognitive","prevention","reserve","resilience","resistance","validation","well-being","aging","NOT_YET_RECRUITING","2026-06-09",{"date":278,"type":279},"2026-06-11","ACTUAL",{"date":281,"type":249},"2026-09",{"date":283,"type":249},"2027-11-27",{"name":5,"class":6},8]