[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567640":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":28,"locations":34,"responsibleParty":52,"collaborators":12,"id":54,"slug":12,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":12,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":12,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":77,"whyStopped":12,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"National Defense Medical Center, Taiwan","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Active iTBS for Patients With MCI or AD","ACTIVE_COMPARATOR","The patient will receive one daily rTMS session for 10 days of iTBS, delivered through an H-coil applied to the left dorsolateral prefrontal cortex. The TBS frequency parameters consist of 3-pulse 50-Hz bursts every 200 ms at 5 Hz, and the intensity will be set at 80% of the active motor threshold (AMT). A single session of iTBS contains 2 s of TBS repeated every 10 s for 20 times.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Sham iTBS for Patients With MCI or AD","SHAM_COMPARATOR","Sham stimulation will be delivered 10 sessions.",[18],"Device: Sham rTMS",[20,24],{"type":21,"name":22,"description":23,"armGroupLabels":12,"otherNames":12},"DEVICE","Active rTMS","iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total10 sessions",{"type":21,"name":25,"description":26,"armGroupLabels":27,"otherNames":12},"Sham rTMS","sham iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total 10 sessions",[14],[29],{"name":30,"role":31,"phone":32,"phoneExt":12,"email":33},"YU-KAI LIN","CONTACT","886-987-859-907","yukai0907@ndmctsgh.edu.tw",[35],{"facility":36,"status":12,"city":37,"state":38,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Tri-Service General Hospital","Taipei","Other","114","Taiwan",{"type":42,"coordinates":43},"Point",[44,45],121.52639,25.05306,{"lat":45,"lon":44},[48,51],{"name":49,"role":31,"phone":50,"phoneExt":12,"email":33},"Yu-Kai Lin","886-2-87923311 ext 10552,13907",{"name":12,"role":31,"phone":32,"phoneExt":12,"email":12},{"type":53,"investigatorFullName":49,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","100567640",false,"NCT06670820","iTBS in MCI and Mild AD","The Effects of Intermittent Theta-burst Stimulation on Cognitive Function in Patients With Mild Cognitive Impairment and Mild Alzheimer's Disease and the Role of Brain-Derived Neurotrophic Factor","Inclusion Criteria:\n\n* Clinical diagnosis of MCI (overall Clinical Dementia Rating of 0.5)\n* Clinical diagnosis of mild Alzheimer's Disease (overall Clinical Dementia Rating of 0.5 or 1)\n\nExclusion Criteria:\n\n* History of stroke\n* History of uncontrol seizure\n* History of significant head trauma followed by persistent neurologic deficit or known structural brain abnormality\n* Mental illness\n* Drug abuse","ALL","50 Years","85 Years",{"count":64,"type":65},80,"ESTIMATED","INTERVENTIONAL",[68],"NA","This study aims to examine the effects of iTBS on cognitive function in individuals with MCI or mild AD, with a secondary objective of exploring prefrontal TBS mechanisms for cognitive function and the effect of iTBS on BDNF.",[71,72],"Mild Cognitive Impairment (MCI)","Mild Alzheimer Disease",[74,75,76,72],"rTMS","iTBS","Mild Cognitive Impairment","NOT_YET_RECRUITING","2024-10-31",{"date":80,"type":81},"2024-11-01","ACTUAL",{"date":78,"type":65},{"date":84,"type":65},"2028-12-31",{"name":5,"class":6},1]