[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603103":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":26,"responsibleParty":408,"collaborators":10,"id":410,"slug":10,"hasResults":411,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":415,"eligibilityCriteria":416,"healthyVolunteers":411,"sex":417,"minAge":418,"maxAge":10,"enrollmentInfo":419,"targetDuration":10,"studyType":422,"phases":10,"briefSummary":423,"conditions":424,"keywords":427,"overallStatus":429,"whyStopped":10,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":439},{"fullName":5,"class":6},"University Hospital, Brest","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Biological sample collection",null,"Biobank establishment and stool sample collection for gut microbiota analysis",[13],"Other: biobank sample collection",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"biobank sample collection","At inclusion, patients will benefit from blood testing for biobank establishment, and stool sample collection for gut microbiota analysis will be organized depending on the center.\n\nThe 12-month visit (M12) will also include an additional blood sample collection as part of the biobank, as well as stool sample collection",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":24,"email":25},"Valérie DEVAUCHELLE, Pr","CONTACT","0298347264","+33","valerie.devauchelle-pensec@chu-brest.fr",[27,43,56,66,79,92,105,118,131,144,157,170,183,196,209,222,235,248,261,274,287,300,313,323,333,346,359,372,385,395],{"facility":28,"status":10,"city":29,"state":29,"zip":30,"country":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"CHU Rouen","Rouen","76038","France",{"type":33,"coordinates":34},"Point",[35,36],1.09932,49.44313,{"lat":36,"lon":35},[39],{"name":40,"role":22,"phone":41,"phoneExt":10,"email":42},"GÉRARD, Dr","02.32.88.90.19","baptiste.gerard@chu-rouen.fr",{"facility":44,"status":10,"city":45,"state":10,"zip":46,"country":31,"cosmosGeoPoint":47,"geoPoint":51,"contacts":52},"Besançon-CIC","Besançon","25000",{"type":33,"coordinates":48},[49,50],6.01815,47.24878,{"lat":50,"lon":49},[53],{"name":54,"role":22,"phone":10,"phoneExt":10,"email":55},"Eric TOUSSIROT, Pr","etoussirot@chu-besancon.fr",{"facility":57,"status":10,"city":45,"state":10,"zip":58,"country":31,"cosmosGeoPoint":59,"geoPoint":61,"contacts":62},"CHU Besançon","25030",{"type":33,"coordinates":60},[49,50],{"lat":50,"lon":49},[63],{"name":64,"role":22,"phone":10,"phoneExt":10,"email":65},"Daniel WENDLING, Pr","dwendling@chu-besancon.fr",{"facility":67,"status":10,"city":68,"state":10,"zip":69,"country":31,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"CHU de Bordeaux Pellegrin","Bordeaux","33076",{"type":33,"coordinates":71},[72,73],-0.58046,44.84124,{"lat":73,"lon":72},[76],{"name":77,"role":22,"phone":10,"phoneExt":10,"email":78},"Marie-Elise TRUCHETET, Pr","marie-elise.truchetet@chu-bordeaux.fr",{"facility":80,"status":10,"city":81,"state":10,"zip":82,"country":31,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"CH Boulogne\u002Fmer","Boulogne-sur-Mer","62321",{"type":33,"coordinates":84},[85,86],1.61373,50.72485,{"lat":86,"lon":85},[89],{"name":90,"role":22,"phone":10,"phoneExt":10,"email":91},"Renaud DESBARBIEUX","r.desbarbieux@ch-boulogne.fr",{"facility":93,"status":10,"city":94,"state":10,"zip":95,"country":31,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"CHU de Brest","Brest","29609",{"type":33,"coordinates":97},[98,99],-4.48628,48.39029,{"lat":99,"lon":98},[102,103],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":25},{"name":21,"role":104,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"facility":106,"status":10,"city":107,"state":10,"zip":108,"country":31,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"CHU de Caen","Caen","14033",{"type":33,"coordinates":110},[111,112],-0.35912,49.18585,{"lat":112,"lon":111},[115],{"name":116,"role":22,"phone":10,"phoneExt":10,"email":117},"Anne-Christine RAT","rat-ac@chu-caen.fr",{"facility":119,"status":10,"city":120,"state":10,"zip":121,"country":31,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"Clinique de l'Infirmerie Protestante de Lyon","Caluire-et-Cuire","69300",{"type":33,"coordinates":123},[124,125],4.8464,45.79462,{"lat":125,"lon":124},[128],{"name":129,"role":22,"phone":10,"phoneExt":10,"email":130},"BASCH, Dr","andcroco@gmail.com",{"facility":132,"status":10,"city":133,"state":10,"zip":134,"country":31,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"CHU de Clermont-Ferrand","Clermont-Ferrand","63003",{"type":33,"coordinates":136},[137,138],3.08682,45.77969,{"lat":138,"lon":137},[141],{"name":142,"role":22,"phone":10,"phoneExt":10,"email":143},"Anne TOURNADRE, Pr","atournadre@chu-clermontferrand.fr",{"facility":145,"status":10,"city":146,"state":10,"zip":147,"country":31,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"CH Dax","Dax","40107",{"type":33,"coordinates":149},[150,151],-1.05366,43.71032,{"lat":151,"lon":150},[154],{"name":155,"role":22,"phone":10,"phoneExt":10,"email":156},"Emilie SHIPLEY, Dr","shipleye@ch-dax.fr",{"facility":158,"status":10,"city":159,"state":10,"zip":160,"country":31,"cosmosGeoPoint":161,"geoPoint":165,"contacts":166},"CHU de Dijon","Dijon","21000",{"type":33,"coordinates":162},[163,164],5.01391,47.31344,{"lat":164,"lon":163},[167],{"name":168,"role":22,"phone":10,"phoneExt":10,"email":169},"André RAMON, Pr","andre.ramon@chu-dijon.fr",{"facility":171,"status":10,"city":172,"state":10,"zip":173,"country":31,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"CH La Roche s\u002F Yon","La Roche-sur-Yon","85925",{"type":33,"coordinates":175},[176,177],-1.42757,46.66974,{"lat":177,"lon":176},[180],{"name":181,"role":22,"phone":10,"phoneExt":10,"email":182},"CORMIER, Dr","gregoire.cormier@ght85.fr",{"facility":184,"status":10,"city":185,"state":10,"zip":186,"country":31,"cosmosGeoPoint":187,"geoPoint":191,"contacts":192},"APHP - Kremlin-Bicêtre","Le Kremlin-Bicêtre","94270",{"type":33,"coordinates":188},[189,190],2.36073,48.81471,{"lat":190,"lon":189},[193],{"name":194,"role":22,"phone":10,"phoneExt":10,"email":195},"SEROR, Pr","raphaele.seror@aphp.fr",{"facility":197,"status":10,"city":198,"state":10,"zip":199,"country":31,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"CH Le Mans","Le Mans","72037",{"type":33,"coordinates":201},[202,203],0.20251,48.0021,{"lat":203,"lon":202},[206],{"name":207,"role":22,"phone":10,"phoneExt":10,"email":208},"Emmanuelle DERNIS, Dr","edernis@ch-lemans.fr",{"facility":210,"status":10,"city":211,"state":10,"zip":212,"country":31,"cosmosGeoPoint":213,"geoPoint":217,"contacts":218},"CHU de Lille","Lille","59037",{"type":33,"coordinates":214},[215,216],3.05512,50.63391,{"lat":216,"lon":215},[219],{"name":220,"role":22,"phone":10,"phoneExt":10,"email":221},"Bernard CORTET, Pr","Bernard.CORTET@chu-lille.fr",{"facility":223,"status":10,"city":224,"state":10,"zip":225,"country":31,"cosmosGeoPoint":226,"geoPoint":230,"contacts":231},"Institut catholique de Lille","Lomme","59160",{"type":33,"coordinates":227},[228,229],2.98715,50.64358,{"lat":229,"lon":228},[232],{"name":233,"role":22,"phone":10,"phoneExt":10,"email":234},"PACAUD, Dr","pacaud.aurore@ghicl.net",{"facility":236,"status":10,"city":237,"state":10,"zip":238,"country":31,"cosmosGeoPoint":239,"geoPoint":243,"contacts":244},"CHU Marseille AP-HM","Marseille","13009",{"type":33,"coordinates":240},[241,242],5.38107,43.29695,{"lat":242,"lon":241},[245],{"name":246,"role":22,"phone":10,"phoneExt":10,"email":247},"Thao PHAM, Pr","Thao.PHAM@ap-hm.fr",{"facility":249,"status":10,"city":250,"state":10,"zip":251,"country":31,"cosmosGeoPoint":252,"geoPoint":256,"contacts":257},"CH Le Havre","Montivilliers","76290",{"type":33,"coordinates":253},[254,255],0.18769,49.54518,{"lat":255,"lon":254},[258],{"name":259,"role":22,"phone":10,"phoneExt":10,"email":260},"BREVET, Dr","pauline.brevet@ch-havre.fr",{"facility":262,"status":10,"city":263,"state":10,"zip":264,"country":31,"cosmosGeoPoint":265,"geoPoint":269,"contacts":270},"CHU de Montpellier","Montpellier","34295",{"type":33,"coordinates":266},[267,268],3.87635,43.61093,{"lat":268,"lon":267},[271],{"name":272,"role":22,"phone":10,"phoneExt":10,"email":273},"Jacques MOREL, Pr","j-morel@chu-montpellier.fr",{"facility":275,"status":10,"city":276,"state":10,"zip":277,"country":31,"cosmosGeoPoint":278,"geoPoint":282,"contacts":283},"CH Morlaix","Morlaix","29672",{"type":33,"coordinates":279},[280,281],-3.82792,48.57784,{"lat":281,"lon":280},[284],{"name":285,"role":22,"phone":10,"phoneExt":10,"email":286},"Catherine LE HENAFF","CLehenaff@ch-morlaix.fr",{"facility":288,"status":10,"city":289,"state":10,"zip":290,"country":31,"cosmosGeoPoint":291,"geoPoint":295,"contacts":296},"CHU de Nice","Nice","06000",{"type":33,"coordinates":292},[293,294],7.26608,43.70313,{"lat":294,"lon":293},[297],{"name":298,"role":22,"phone":10,"phoneExt":10,"email":299},"Christian ROUX, Pr","roux.c2@chu-nice.fr",{"facility":301,"status":10,"city":302,"state":10,"zip":303,"country":31,"cosmosGeoPoint":304,"geoPoint":308,"contacts":309},"AP-HP La Pitié-Salpétrière","Paris","75013",{"type":33,"coordinates":305},[306,307],2.3488,48.85341,{"lat":307,"lon":306},[310],{"name":311,"role":22,"phone":10,"phoneExt":10,"email":312},"Bruno FAUTREL, Pr","bruno.fautrel@aphp.fr",{"facility":314,"status":10,"city":302,"state":10,"zip":315,"country":31,"cosmosGeoPoint":316,"geoPoint":318,"contacts":319},"AP-HP Cochin","75014",{"type":33,"coordinates":317},[306,307],{"lat":307,"lon":306},[320],{"name":321,"role":22,"phone":10,"phoneExt":10,"email":322},"FOGEL, Dr","olivier.fogel@aphp.fr",{"facility":324,"status":10,"city":302,"state":10,"zip":325,"country":31,"cosmosGeoPoint":326,"geoPoint":328,"contacts":329},"AP-HP Bichat","75018",{"type":33,"coordinates":327},[306,307],{"lat":307,"lon":306},[330],{"name":331,"role":22,"phone":10,"phoneExt":10,"email":332},"Philippe DIEUDE, Pr","philippe.dieude@aphp.fr",{"facility":334,"status":10,"city":335,"state":10,"zip":336,"country":31,"cosmosGeoPoint":337,"geoPoint":341,"contacts":342},"Hopital NOVO - Site Pontoise","Pontoise","95300",{"type":33,"coordinates":338},[339,340],2.1,49.05,{"lat":340,"lon":339},[343],{"name":344,"role":22,"phone":10,"phoneExt":10,"email":345},"AL TABAA, Dr","omar.altabaa@ght-novo.fr",{"facility":347,"status":10,"city":348,"state":10,"zip":349,"country":31,"cosmosGeoPoint":350,"geoPoint":354,"contacts":355},"CHU Saint-Etienne","Saint-Priest-en-Jarez","42270",{"type":33,"coordinates":351},[352,353],4.37678,45.4739,{"lat":353,"lon":352},[356],{"name":357,"role":22,"phone":10,"phoneExt":10,"email":358},"MAROTTE, Pr","hubert.marotte@chu-st-etienne.fr",{"facility":360,"status":10,"city":361,"state":10,"zip":362,"country":31,"cosmosGeoPoint":363,"geoPoint":367,"contacts":368},"CHU Strasbourg","Strasbourg","67098",{"type":33,"coordinates":364},[365,366],7.74553,48.58392,{"lat":366,"lon":365},[369],{"name":370,"role":22,"phone":10,"phoneExt":10,"email":371},"Jacques-Eric GOTTENBERG, Pr","jacques-eric.gottenberg@chru-strasbourg.fr",{"facility":373,"status":10,"city":374,"state":10,"zip":375,"country":31,"cosmosGeoPoint":376,"geoPoint":380,"contacts":381},"Clinique Ambroise Paré-Toulouse","Toulouse","31000",{"type":33,"coordinates":377},[378,379],1.44367,43.60426,{"lat":379,"lon":378},[382],{"name":383,"role":22,"phone":10,"phoneExt":10,"email":384},"Martin MICHAUD, Pr","m.michaud@clinique-ambroise-pare.fr",{"facility":386,"status":10,"city":374,"state":10,"zip":387,"country":31,"cosmosGeoPoint":388,"geoPoint":390,"contacts":391},"CHU de Toulouse","31059",{"type":33,"coordinates":389},[378,379],{"lat":379,"lon":378},[392],{"name":393,"role":22,"phone":10,"phoneExt":10,"email":394},"Adeline RUYSSEN-WITRAND, Pr","ruyssen-witrand.a@chu-toulouse.fr",{"facility":396,"status":10,"city":397,"state":10,"zip":398,"country":31,"cosmosGeoPoint":399,"geoPoint":403,"contacts":404},"CHU de Tours","Tours","37044",{"type":33,"coordinates":400},[401,402],0.70398,47.39484,{"lat":402,"lon":401},[405],{"name":406,"role":22,"phone":10,"phoneExt":10,"email":407},"Guillemo CARVAJAL ALEGRIA, Dr","guillermo.carvajal@univ-tours.fr",{"type":409,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100603103",false,"NCT07132164","Justification of the Initial Diagnosis and Evaluation of the Overall Evolution of a Cohort of Recent Polymyalgia Rheumatica (JADORE)","Justification of the Initial Diagnosis and Evaluation of the Overall Evolution of a Cohort of Recent Polymyalgia Rheumatica","JADORE","Inclusion Criteria:\n\n* Age greater than or equal to 50, with no upper age limit\n* Inflammatory shoulder +\u002F- hip pain\n* Abnormal CRP (≥10mg\u002FL)\n* Patients for whom the referring rheumatologist accepts the diagnosis of PPR after carrying out the assessment corresponding to his or her current practice\n* Patients for whom the referring rheumatologist has indicated that corticosteroid therapy should be started in the strict context of PPR or as background treatment for PPR.\n* Symptoms have progressed for 24 weeks or less\n\nExclusion Criteria:\n\n* Presence, at the time of diagnosis, of symptoms and\u002For signs suggesting a diagnosis of associated giant cell arteritis\n* Immuno-induced PPR\n* Patients receiving immunosuppressive treatment with methotrexate or immunotherapy targeting interleukin-6 at inclusion.\n* Patients who have received corticosteroid therapy for more than 30 days or a cumulative dose of more than 500 mg of Prednisone equivalent in the month preceding the screening visit.\n* Patients with another chronic condition requiring long-term corticosteroid therapy or repeated courses of corticosteroids.\n* Patients not affiliated to a social security scheme\n* Patients unable to consent or unable or unwilling to complete their corticosteroid dose monitoring record.\n* Pregnancy\n* Patients under guardianship, curatorship or safeguard of justice","ALL","50 Years",{"count":420,"type":421},400,"ESTIMATED","OBSERVATIONAL","Pseudo-rheumatoid arthritis (PRA) is a common inflammatory rheumatic disease of the elderly, characterized by inflammatory shoulder and\u002For hip pain. Its routine diagnosis is based on a number of clinical criteria, the presence of a biological inflammatory syndrome and the elimination of the main differential diagnoses. It is sometimes referred to as PPR syndrome, since around 25% of initial diagnoses are not confirmed at one year's follow-up (PPR syndrome revealing rheumatoid arthritis, microcrystalline rheumatism, etc.). Diagnosis may be facilitated by ultrasound scans of the shoulders and hips, which may show characteristic inflammatory lesions, or by PET scans when there is a marked deterioration in general condition or other clinical atypia. PPR may be associated at the outset, or it may evolve into the rarer vasculitis of the elderly, giant cell arteritis (GCA), a condition that can lead to severe and irreversible neurological vascular damage if not treated early.\n\nProlonged, moderate-dose corticosteroid therapy is the cornerstone of PPR treatment, although new treatments are in the process of obtaining marketing authorization to enable cortisone sparing. Anti-IL-6 agents, and in particular Tocilizumab, have demonstrated their efficacy in recent cortico-dependent PPR, Sarilumab has obtained marketing authorization for cortico-dependent PPR in the USA in 2023, and other therapeutic classes are currently being evaluated in this situation. Recommendations, including those of ACR\u002FEULAR in 2015, advise a strategy of initiating corticosteroid therapy at a moderate dose, with a dosage of between 12.5 and 25 mg prednisone equivalent per day, and gradually tapering off with the aim of reaching a dosage of 10 mg prednisone equivalent per day at week 8, to achieve complete weaning at 12 months. However, on the one hand, these recommendations are not based on clinical trials and, on the other, the main comorbidities associated with PPR are related to this long-term corticosteroid therapy. Lastly, we know that around 50% of patients do not follow this tapering-off protocol, with either relapses (estimated at 50% during tapering) or the impossibility for around 25% of patients to stop corticosteroid therapy. However, there are currently no predictive factors for the evolution of PPR.\n\nPPR activity can be measured either using a validated score, the DAS-PPR, or according to the opinion of the rheumatologist. Good progression of rheumatoid arthritis is characterized by a low activity score (DAS-PPR\\\u003C10) and, wherever possible, discontinuation of treatment within one year, as recommended by international experts.\n\nThe main objective of this cohort is therefore to evaluate the percentage of patients with low-activity PPR (DAS-PPR\\\u003C10) and no treatment at 12 months.\n\nSecondary objectives will concern the initial phenotypic and evolutionary description of PPR (complete initial phenotypic characteristics, including some exploratory ones (imaging, biology, immunology, genetics, microbiota, avatars). The evolution of the disease, with the percentage of relapses during the decline or distant relapses, percentage of association with ACG, mortality rate, as well as the prognostic factors of these different evolutionary forms. A description of the disease-modifying treatments used (corticosteroid therapy and its decline, other immunomodulators), as well as a record of the complications presented by patients (development of ACG, corticosteroid toxicity, sarcopenia, osteoporosis fractures, diverticular perforation). Finally, many pathologies can clinically and biologically mimic PPR, leading to erroneous prescriptions of glucocorticoids for prolonged periods, and sometimes a delay in the diagnosis of serious conditions. These classic differential diagnoses will be investigated according to the clinical context and the clinician's judgement, and the diagnostic value of tests such as joint ultrasound, PET scans and biomarkers can be assessed.\n\nWith regard to patient follow-up, if an alternative diagnosis is identified immediately after the completion of additional examinations, the patient is no longer followed up in the study, and the alternative diagnosis is noted by the investigator. For patients for whom the investigator's conviction concerning the diagnosis of PPR remains above 50%, as at inclusion, follow-up in the study is continued. At one year's follow-up, if an alternative diagnosis has been made, this is collected and the patient is no longer followed up in the cohort. Follow-up for other patients then continues for 5 years. Deterministic matching to the SNDS will be performed for each patient included.\n\nTo date, there is no French prospective cohort dedicated to the follow-up of patients with a recent form of PPR, as has been done for rheumatoid arthritis, spondyloarthritis and psoriatic arthritis. The creation of such a cohort will improve our knowledge of this pathology, in terms of both pathophysiology and routine management.",[425,426],"Polymyalgia Rheumatica","Inflammatory Rheumatism",[428],"polymyalgia Rheumatica","NOT_YET_RECRUITING","2026-06-05",{"date":432,"type":433},"2026-06-08","ACTUAL",{"date":435,"type":421},"2026-07-01",{"date":437,"type":421},"2035-07-01",{"name":5,"class":6},30]