[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100444939":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":38,"studyPopulation":38,"armGroups":44,"interventions":56,"overallOfficials":38,"centralContacts":38,"locations":65,"responsibleParty":95,"collaborators":38,"id":98,"slug":38,"hasResults":99,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":38,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":105,"minAge":106,"maxAge":38,"enrollmentInfo":107,"targetDuration":38,"studyType":110,"phases":111,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":68,"whyStopped":38,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},{"fullName":5,"class":6},"University of Milan","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":25},[9],{"measure":10,"description":11,"timeFrame":12},"Widht of Keratinized mucosa","variation of keratized mucosa from t0","2-4-8-12-24 weeks - 1-2-3-4-5 years",[14,18,21],{"measure":15,"description":16,"timeFrame":17},"implant survival","Implant in function","1-2-3-4-5 years",{"measure":19,"description":20,"timeFrame":17},"marginal bone loss","variation of marginal bone loss over time",{"measure":22,"description":23,"timeFrame":24},"Vas Scale","Prom: patient VAS scale for post-operative pain, from 0 to 10, where 10 is higher and 0 is minimum.","2 weeks",[26,30],{"measure":27,"description":28,"timeFrame":29},"Time","surgical time differences between the two groups","day 1",{"measure":31,"description":32,"timeFrame":17},"prosthetic complications","number and type of prosthetic complications over time",{"allocation":34,"interventionModel":35,"interventionModelDescription":36,"primaryPurpose":37,"observationalModel":38,"timePerspective":38,"maskingInfo":39},"RANDOMIZED","PARALLEL","two groups will be compared with different treatment","DIAGNOSTIC",null,{"masking":40,"maskingDescription":41,"whoMasked":42},"SINGLE","surgical treatment will be conducted with surgeon-investigator and patient unblinded. the outcome assessor will be blinded as primary outcome measurements will be taken on a computer.",[43],"OUTCOMES_ASSESSOR",[45,51],{"label":46,"type":47,"description":48,"interventionNames":49},"Connective tissue graft","ACTIVE_COMPARATOR","patient in this group will be treated with a flap and a connective tissue graft at the moment of implant placement.",[50],"Procedure: Connective tissue graft",{"label":52,"type":47,"description":53,"interventionNames":54},"Flapess","patient in this group will be treated with a flapless approach at the moment of implant placement.",[55],"Procedure: Flapless",[57,61],{"type":58,"name":46,"description":59,"armGroupLabels":60,"otherNames":38},"PROCEDURE","Implants will be placed with a flap and a connective tissue graft.",[46],{"type":58,"name":62,"description":63,"armGroupLabels":64,"otherNames":38},"Flapless","Implants will be placed with a flapless approach",[52],[66],{"facility":67,"status":68,"city":69,"state":70,"zip":71,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":80},"Clinica Odontoiatrica Giorgio Vogel","RECRUITING","Milan","MI","20142","Italy","IT",{"type":75,"coordinates":76},"Point",[77,78],9.18951,45.46427,{"lat":78,"lon":77},[81,86,89,91,93],{"name":82,"role":83,"phone":84,"phoneExt":38,"email":85},"Stefano Storelli, PHD","CONTACT","0250319003","stefano.storelli@unimi.it",{"name":87,"role":83,"phone":84,"phoneExt":38,"email":88},"Eugenio Romeo, Prof.","eugenio.romeo@unimi.it",{"name":82,"role":90,"phone":38,"phoneExt":38,"email":38},"PRINCIPAL_INVESTIGATOR",{"name":87,"role":92,"phone":38,"phoneExt":38,"email":38},"SUB_INVESTIGATOR",{"name":94,"role":92,"phone":38,"phoneExt":38,"email":38},"Giulia Palandrani, Msc",{"type":90,"investigatorFullName":96,"investigatorTitle":97,"investigatorAffiliation":5,"oldNameTitle":38,"oldOrganization":38},"Stefano Storelli","Reasearcher","100444939",false,"NCT05073952","Keratized Mucosa in CG Implant Placement: CTG vs Flapless","Width of Keratinazed Mucosa in Immediately Loaded Posterior Implant Restorations Treated With Different Surgical Approaches: Randomized Clinical Study.","Inclusion Criteria:\n\n* Age 18+\n* Patients with partial edentulism in the posterior region (4-7) upper or lower for at least 3 months\n* Patient whose tomographic examination shows adequate bone volumes for computer guided placement of a standard diameter implant (\\> 3.5 mm) without the need for bone regeneration procedures\n* Patients who have accepted informed consent and participation in the study\n* Patients who do not have exclusion criteria\n\nEclusion Criteria\n\n* Patients who refuse to co-operate\n* Systemic conditions of exclusion:\n\n  * Medical conditions requiring prolonged use of steroids\n  * Severe hemophilia\n  * In therapy with intravenous bisphosphonates\n  * History of white blood cell dysfunction or deficiency\n  * History of head and neck radiotherapy or chemotherapy\n  * History of kidney failure\n  * Pregnant or breastfeeding patient\n  * History of uncontrolled endocrine disorders\n  * Physical handicaps that hinder proper oral hygiene\n  * Use of experimental devices or drugs within 30 days prior to implant placement surgery\n  * Alcoholism or drug abuse\n  * Smokers of\\> 10 cigarettes per day or the equivalent cigar or\\> 10 tobacco-based chewings per day\n  * Conditions or circumstances that prevent the completion of participation in the study or interfere with the analysis of the study results\n\nLocal exclusion conditions:\n\n* Local inflammation, including untreated periodontitis\n* Patients with erosive lichen planus\n* History of local radiation therapy\n* Presence of bone lesions\n* Unhealed extraction sites\n* History of bone reconstruction and bone grafting techniques in the sites where the implants are to be inserted\n* Bruxism\n* Bleeding index\\> 30% and number of pockets\\> 5mm greater than 10",true,"ALL","18 Years",{"count":108,"type":109},44,"ESTIMATED","INTERVENTIONAL",[112],"NA","The present study will evaluate the difference in terms of keratinazed mucosa (KM) in computer guided implant placement with immediate loading, comparing a flapless approach to flap surgery with connective tissue graft.",[115],"Variation of Keratinized Mucosa After Implant Surgery",[117,118,46,119,120,121],"dental implant","Keratinized mucosa","flapless implant placement","Computer guided implantology","Immediate loading","2021-12-02",{"date":124,"type":125},"2021-12-03","ACTUAL",{"date":127,"type":125},"2021-10-18",{"date":129,"type":109},"2028-06-01",{"name":5,"class":6},1]