[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597841":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":25,"locations":30,"responsibleParty":63,"collaborators":25,"id":67,"slug":25,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":25,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":25,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":25,"overallStatus":33,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"McMaster University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"High Altitude (3800m; Barcroft Research Station)","EXPERIMENTAL","High altitude setting",[13,14],"Dietary Supplement: Ketone Monoester (KME)","Dietary Supplement: Placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"Low Altitude (334m; University of Guelph)","Low altitude setting",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Ketone Monoester (KME)","0.6 g KME per kg body mass; \\[R\\]-3-hydroxybutyl \\[R\\]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo","Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement",[9,16],[31,50],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Barcroft Research Station","RECRUITING","Bishop","California","93514","United States",{"type":39,"coordinates":40},"Point",[41,42],-118.39511,37.36354,{"lat":42,"lon":41},[45],{"name":46,"role":47,"phone":48,"phoneExt":25,"email":49},"Jeremy Walsh, PhD","CONTACT","9055259140","walshj18@mcmaster.ca",{"facility":51,"status":33,"city":52,"state":53,"zip":54,"country":55,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"University of Guelph","Guelph","Ontario","N1G 2W1","Canada",{"type":39,"coordinates":57},[58,59],-80.25599,43.54594,{"lat":59,"lon":58},[62],{"name":46,"role":47,"phone":48,"phoneExt":25,"email":49},{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Jeremy Walsh","Assistant Professor","100597841",false,"NCT07063732","Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise","The Effect of Ketone Monoester Supplementation and High Altitude on Exercising Cerebral Blood Flow","Inclusion Criteria:\n\n\\- Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California\n\nExclusion Criteria:\n\n* BMI \\> 30\n* No prescribed medications (oral contraceptives excluded)\n* History of smoking\n* Currently following a ketogenic diet or consuming exogenous ketogenic supplements\n* History of heart, lung, blood vessel, or kidney disease\n* Currently pregnant",true,"ALL","18 Years","35 Years",{"count":78,"type":79},14,"ESTIMATED","INTERVENTIONAL",[82],"NA","The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME\u002Fkg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.",[85,86],"High Altitude Hypoxia","Exercise","2025-07-02",{"date":89,"type":90},"2025-07-14","ACTUAL",{"date":92,"type":90},"2025-05-28",{"date":94,"type":79},"2025-08-31",{"name":5,"class":6},2]