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Vaudois","ACTIVE_NOT_RECRUITING","Lausanne","1011",{"type":54,"coordinates":217},[218,219],6.63282,46.516,{"lat":219,"lon":218},{"type":222,"investigatorFullName":223,"investigatorTitle":224,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Thomas Riva","Prof. Dr. med.",[226,228,230,232,234,236,238,240,242,243],{"name":227,"class":6},"University Hospital, Geneva",{"name":229,"class":6},"Kantonsspital Aarau",{"name":231,"class":6},"Centre Hospitalier Universitaire Vaudois",{"name":233,"class":6},"Charite University, Berlin, Germany",{"name":68,"class":235},"UNKNOWN",{"name":237,"class":6},"The Hospital for Sick Children",{"name":239,"class":6},"Istituto Giannina Gaslini",{"name":241,"class":235},"Cantonal Hospital of Lucerne",{"name":47,"class":6},{"name":244,"class":6},"Montreal Children's Hospital of the MUHC","100513594",false,"NCT05967507","Laryngoscopy for Neonatal and Infant Airway Management wIth Supplemental Oxygen at Different Flow Rates (OPTIMISE-2)","Laryngoscopy for Neonatal and Infant Airway Management wIth Supplemental Oxygen at Different Flow Rates (OPTIMISE-2): a Multi-center, Non-inferiority, Prospective Randomized Controlled Trial","OPTIMISE-2","Inclusion Criteria:\n\n* Pediatric patients requiring oral or nasal tracheal intubation for elective, semi-elective, or urgent surgical and non-surgical indications.\n* Neonates and infants up to 52 weeks postconceptual age, with legal guardians providing written informed consent before the intervention\n\nExclusion Criteria:\n\n* Prediction of difficult intubation upon physical examination or previous history of difficult intubation, mandating a technique different than direct laryngoscopy to secure the airway;\n* Congenital heart disease demanding FiO2 \\\u003C 1.0\n* Cardiopulmonary collapse requiring advanced life support\n* Intubation for emergency surgical and non-surgical indications.","ALL","52 Weeks",{"count":255,"type":256},1192,"ESTIMATED","INTERVENTIONAL",[259],"NA","This study aims to investigate the optimal oxygen flow rate needed during tracheal intubation with the C-MAC video laryngoscope (Karl Storz, Tuttlingen, Germany) using Miller-blade or Macintosh-blade size No. 0 or No. 1 in the operating room or intensive care unit. The investigators hypothesize that the difference between low-flow and high-flow supplemental oxygen is negligible.",[262],"Airway Management","2026-05-09",{"date":265,"type":266},"2026-05-12","ACTUAL",{"date":268,"type":266},"2023-12-01",{"date":270,"type":256},"2027-09",{"name":223,"class":6},11]