About this trial

This study will develop a whole-of-body markerless tracking method for measuring the motion of the tumour and surrounding organs during radiation therapy to enable real-time image guidance.

Routinely acquired patient data will be used to improve the training, testing and accuracy of a whole-of-body markerless tracking method. When the markerless tracking method is sufficiently advanced, according to the PI of each of the data collection sites, the markerless tracking method will be run in parallel to, but not intervening with, patient treatments during data acquisition.

Eligibility criteria

Qualifiers

Will receive radiation therapy for brain, breast, head and neck, kidney, liver, pancreas, prostate, spine cancer treatment or cardiac arrhythmia treatment at a participating centre.

Will receive CT planning, and a cone beam CT scan for at least one fraction of radiation therapy.

Will receive intrafraction x-ray imaging for the liver, pancreas, prostate, spine cancer treatment or cardiac arrhythmia treatment. As intrafraction imaging is not common standard of care for brain, breast, head and neck and kidney cancer treatments there is no requirement to have intrafraction x-ray imaging data for these anatomical sites.

Provides written informed consent.

Disqualifiers

Less than 18 years of age

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

300 Participants
are grouped into 9 trial groups

9

Trial groups

See each trial group below.

Locations

4
Royal North Shore Hospital2065, Saint LeonardsNew South Wales, Australia
Princess Alexandra Hospital4102, WoolloongabbaQueensland, Australia
Alfred Health3000, MelbourneVictoria, Australia
Peter MacCallum Cancer Centre3000, MelbourneVictoria, Australia

Sponsors and collaborators

University of Sydney

Lead sponsor

Princess Alexandra Hospital, Brisbane, Australia

Collaborator

Calvary Mater Newcastle, Australia

Collaborator

Western Sydney Local Health District

Collaborator

Austin Health

Collaborator

Peter MacCallum Cancer Centre, Australia

Collaborator