[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100405428":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":15,"centralContacts":22,"locations":27,"responsibleParty":105,"collaborators":7,"id":107,"slug":7,"hasResults":108,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":7,"eligibilityCriteria":112,"healthyVolunteers":108,"sex":113,"minAge":114,"maxAge":7,"enrollmentInfo":115,"targetDuration":7,"studyType":118,"phases":7,"briefSummary":119,"conditions":120,"keywords":123,"overallStatus":30,"whyStopped":7,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},{"fullName":5,"class":6},"Lifetech Scientific (Shenzhen) Co., Ltd.","INDUSTRY",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"DIAGNOSTIC_TEST","Transthoracic Echocardiography","After the surgey, the tests data will be collected during 8 visits when the subjects go back to the hospital.",[14],"Transesophageal Echocardiography",[16,20],{"name":17,"affiliation":18,"role":19},"Chenyang Jiang, Doctor","Sir Run Run Shaw Hospital","PRINCIPAL_INVESTIGATOR",{"name":21,"affiliation":18,"role":19},"Jinhua Zhang, Doctor",[23],{"name":17,"role":24,"phone":25,"phoneExt":7,"email":26},"CONTACT","8613857190051","panshangming@lifetechmed.com",[28,47,62,78,94],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Qilu Hospital of Shandong University","RECRUITING","Jinan","Shandong","250000","China",{"type":36,"coordinates":37},"Point",[38,39],116.99722,36.66833,{"lat":39,"lon":38},[42,46],{"name":43,"role":24,"phone":44,"phoneExt":7,"email":45},"Zhong Jingquan, Doctor","18560086597","18560086597@163.com",{"name":43,"role":19,"phone":7,"phoneExt":7,"email":7},{"facility":48,"status":30,"city":49,"state":50,"zip":51,"country":34,"cosmosGeoPoint":52,"geoPoint":56,"contacts":57},"Shanghai Songjiang District Central Hospital","Shanghai","Shanghai Municipality","200000",{"type":36,"coordinates":53},[54,55],121.45806,31.22222,{"lat":55,"lon":54},[58,61],{"name":59,"role":24,"phone":60,"phoneExt":7,"email":7},"Zhao Wenbiao, Doctor","18918288026",{"name":59,"role":19,"phone":7,"phoneExt":7,"email":7},{"facility":63,"status":30,"city":64,"state":65,"zip":66,"country":34,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Sichuan Mianyang 404 Hospital","Mianyang","Sichuan","621000",{"type":36,"coordinates":68},[69,70],104.68168,31.46784,{"lat":70,"lon":69},[73,77],{"name":74,"role":24,"phone":75,"phoneExt":7,"email":76},"Zhang Dayong, Doctor","13890135264","504082447@qq.com",{"name":74,"role":19,"phone":7,"phoneExt":7,"email":7},{"facility":79,"status":30,"city":80,"state":81,"zip":82,"country":34,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"The first Affiliated Hospital of WMU","Wenzhou","Zhejiang","325600",{"type":36,"coordinates":84},[85,86],120.66682,27.99942,{"lat":86,"lon":85},[89,93],{"name":90,"role":24,"phone":91,"phoneExt":7,"email":92},"Huang Weijian, Doctor","13806691086","weijianhuang69@126.com",{"name":90,"role":19,"phone":7,"phoneExt":7,"email":7},{"facility":95,"status":30,"city":80,"state":81,"zip":82,"country":34,"cosmosGeoPoint":96,"geoPoint":98,"contacts":99},"The Second Affiliated Hospital and Yuying Children's Hospital of WMU",{"type":36,"coordinates":97},[85,86],{"lat":86,"lon":85},[100,104],{"name":101,"role":24,"phone":102,"phoneExt":7,"email":103},"Li Yuechun, Doctor","13616776960","liyuechun1980@sina.com",{"name":101,"role":19,"phone":7,"phoneExt":7,"email":7},{"type":106,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100405428",false,"NCT04559243","Left Atrial Appendage Closure as Secondary Prevention of Atrial Fibrillation-related Embolic Events","A Prospective, Multicenter Clinical Study of Percutaneous Left Atrial Appendage Closure as Secondary Prevention of Atrial Fibrillation-related Embolic Events in Patients With Atrial Fibrillation","Inclusion Criteria:\n\n* Age ≥ 18 years, male or female;\n* Patients who are able to understand the purpose of the study, voluntarily participate in and sign the informed consent form (ICF), and are willing to complete the follow-up as required by the protocol;\n* Indications for left atrial appendage closure;\n* Patients with non-valvular AF complicated with previous AF related embolic event and meeting one of the following conditions;\n\n  1. HAS-BLED bleeding risk score ≥ 3 points;\n  2. Not suitable for long-term oral anticoagulant therapy;\n  3. Poor compliance with oral anticoagulants;\n  4. CHA2DS2-VASc score ≧ 2 points;\n\nExclusion Criteria:\n\n* Valvular AF (after moderate to severe mitral stenosis or mechanical valve replacement)\n* Initial AF, reversible AF with clear cause\n* Presence of adherent thrombus in the left atrium or left ventricular aneurysm thrombus\n* ST elevation myocardial infarction, ≤ 3 months\n* Grade-IV of Cardiac Function (NYHA)\n* Allergy or contraindication to metal nitinol, aspirin, clopidogrel, heparin, and other anticoagulants\n* Pregnant or with plan of pregnancy during the study\n* Participation in another drug or medical device clinical trial or study that has not been completed\n* Experience new stroke or TI within 30 days or major bleeding events within 14 days\n* Contraindication to LAA closure or deemed unsuitable for study participation by the investigator\n* Had a definite thromboembolic event","ALL","18 Years",{"count":116,"type":117},579,"ESTIMATED","OBSERVATIONAL","This clinical study is a prospective, multi-center, non-interventional study designed to investigate the safety and effectiveness of percutaneous LAA appendage closure by using LAmbre™ Left Atrial Appendage Occluder System. 579 patients with valvular AF complicated with previous AF-related embolic events (including ischemic stroke, TIA and systemic embolism) were enrolled at about 20 study sites nationwide. The baseline data, operation process and relevant follow-up information of subjects were recorded at 7 months after operation or before discharge and at 1, 3, 6, 12 and 24 months after operation.",[121,122],"Non-valvular Atrial Fibrillation","Embolic Stroke",[124,125,126],"AF-related embolic events","non-valvular atrial fibrillation","Left Atrial Appendage Closure","2022-12-15",{"date":129,"type":130},"2022-12-19","ACTUAL",{"date":132,"type":130},"2020-11-12",{"date":134,"type":117},"2027-11",{"name":5,"class":6},5]