About this trial

Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse remodeling of the left ventricle (LV) in the postoperative period. It is suggested that functional mitral regurgitation (MR) provides supra-physiological left ventricle volume overload and this fact plays positive role in early-stage post-operative left ventricle volume and function recovery. LV volume, systolic and diastolic function will be monitored with echocardiography (EchoCG) along with life quality in patients with different grades of functional mitral regurgitation secondary to severe chronic aortic insufficiency after surgical treatment of aortic regurgitation.

Eligibility criteria

Qualifiers

Age over 18 years

Planned primary elective surgery for chronic aortic regurgitation

Presence of functional mitral regurgitation

End-diastolic volume of the left ventricle >= 250 ml

Disqualifiers

Infectious endocarditis

History of myocardial infarction

Indications on simultaneous myocardial revascularisation

Acute aortic regurgitation of any etiology

Trial design

Treatments tested in this trial

  • Not applicable - observational study

Treatment groups

120 Participants
are divided into 4 treatment groups

Locations

2
Petrovsky National Research Center of Surgery119435, Moscow Russia
Voronezh Regional Clinical Hospital No. 1394066, Voronezh Russia

Sponsors and collaborators

Petrovsky National Research Centre of Surgery

Lead sponsor

Voronezh regional clinical hospital #1

Collaborator