About this trial
This is a phase 2 pragmatic study that evaluates the clinical benefit of continuing systemic therapy with the addition of locally ablative therapies for oligo-progressive solid tumors as the primary objective. The primary outcome measure is the time to treatment failure (defined as time to change in systemic failure or permanent discontinuation of therapy) following locally ablative therapy.
Eligibility criteria
Qualifiers
Cohort A: (Cohort removed in protocol version 4.0)
Cohort B: Small bowel
Cohort C: Pancreatic and ampullary, colorectal, and appendiceal
Cohort D: (Cohort removed in protocol version 4.0)
Disqualifiers
Medical comorbidities precluding locally ablative therapies.
History of treatment related toxicities that limit or prohibit application of locally ablative therapies.
Progressing intracranial lesions.
Trial design
Treatments tested in this trial
- Ablative local therapy
Treatment groups
Locations
1Sponsors and collaborators
University of California, Davis
Lead sponsor
National Cancer Institute (NCI)
Collaborator