This prospective observational study investigates the long-term effects of Dupilumab in patients with NSAID-exacerbated respiratory disease (N-ERD). The study assesses changes in ASA tolerance, clinical parameters, inflammatory biomarkers, quality of life, and nasal microbiome during ongoing treatment with Dupilumab. All participants are receiving Dupilumab as part of standard clinical care.
Participated previously in our preliminary study (EK 1044/2020) and continued Dupilumab treatment since then. Long-term use of Dupilumab since the preliminary study will be assessed based on patient self-report, as there is currently no clinical test or laboratory parameter available to objectively verify treatment duration.
Signed and dated informed consent has been obtained
Current therapy with Dupilumab
Pregnancy (as determined by urine ß-HCG test)
Clinically significant abnormal laboratory values and active infection (Tbc, HIV, hepatitis A/B/C)
History of malignancy or immunodeficiency
Chronic obstructive lung disorders (COPD), other obstructive lung disorders (bronchiolitis)
Medical University of Vienna
Lead sponsor