Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorMayo Clinic

About this trial

The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.

Eligibility criteria

Qualifiers

18-75 years old

Spinal cord injury with neurological level of injury from C6-T12

ASIA Impairment Scale A-D.

Either acute SCI <3 months prior (n=10) or chronic SCI (>1 year since injury, n=8).

Disqualifiers

Symptoms of cardiovascular (including, but not limited to: hypertension, stroke, chest pain, etc.), respiratory, peripheral neurological or autonomic disease (particularly diabetes mellitus requiring treatment);

Women who are pregnant or lactating

Taking or being administered a medication known to potentially have adverse interactions with phenylephrine

In the judgement of the principal investigator, any illness or condition that will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results.

Trial design

Treatments tested in this trial

  • Tests of sympathetic inhibition
  • Tests of above level sympathetic activation
  • Testing of below level sympathetic activation

Treatment groups

18 Participants
are divided into 2 treatment groups

Locations

1
Mayo Clinic55905, RochesterMinnesota, United States

Sponsors and collaborators

Mayo Clinic

Lead sponsor

The Craig H. Neilsen Foundation

Collaborator