[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100427873":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":22,"locations":28,"responsibleParty":46,"collaborators":49,"id":52,"slug":10,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Vanderbilt University Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Individuals with Tourette syndrome (TS)",null,"Individuals previously diagnosed with Tourette syndrome (TS). Participants must be 18 years of age or older.",[13],"Other: None - observational study",[15],{"type":6,"name":16,"description":16,"armGroupLabels":17,"otherNames":10},"None - observational study",[9],[19],{"name":20,"affiliation":5,"role":21},"David A Isaacs, MD, MPH","PRINCIPAL_INVESTIGATOR",[23],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Michelle Eckland, BS","CONTACT","615-875-7394","michelle.r.eckland.1@vumc.org",[29],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"RECRUITING","Nashville","Tennessee","37232-5400","United States",{"type":36,"coordinates":37},"Point",[38,39],-86.78444,36.16589,{"lat":39,"lon":38},[42,44],{"name":24,"role":25,"phone":43,"phoneExt":10,"email":27},"6159362025",{"name":45,"role":21,"phone":10,"phoneExt":10,"email":10},"David Isaacs, MD, MPH",{"type":21,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"David Isaacs","Assistant Professor, Neuro-Movement Disorders Division",[50],{"name":51,"class":6},"University of California, Los Angeles","100427873",false,"NCT04851678","Longitudinal Impact of Stressors in Adults With Tourette Syndrome","LISA-TS","Inclusion Criteria:\n\n* adults (\\>18) meeting Diagnostic and Statistics Manual, 5th edition (DSM-V) criteria for Tourette syndrome, chronic motor tic disorder, or chronic vocal tic disorder\n* ability to provide informed consent\n* English proficiency\n\nExclusion Criteria:\n\n\\- significant medical, neurologic, or psychiatric diagnoses (e.g. uncontrolled epilepsy, chronic heart failure, schizophrenia) besides TS and its commonly co-occurring psychiatric diagnoses","ALL","18 Years",{"count":61,"type":62},140,"ESTIMATED","OBSERVATIONAL","The Investigators propose a two-year, longitudinal pilot study of TS adults (\\>18) to determine impact of lifetime environmental stress exposure on tic severity, psychiatric comorbidity severity, and health-related quality of life (HRQOL).",[66],"Tourette Syndrome",[68,69,70],"Stress","Environmental stress","Psychosocial stress","2026-04-28",{"date":73,"type":74},"2026-05-05","ACTUAL",{"date":76,"type":74},"2021-09-30",{"date":78,"type":62},"2027-06-30",{"name":5,"class":6},1]