[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100540979":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":43,"locations":49,"responsibleParty":69,"collaborators":30,"id":71,"slug":30,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":30,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":52,"whyStopped":30,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"University of Zurich","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Modified Alternate Day Fasting (mADF)","ACTIVE_COMPARATOR","Participants in the mADF group will be instructed to eat every second-day ad libitum (\"feast days\"), and to consume a very low carbohydrate snack, restricted to the evening, provided by the study team and to otherwise abstain from calorie intake on the rest of the fast day.",[13],"Behavioral: Modified Alternate Day Fasting",{"label":15,"type":10,"description":16,"interventionNames":17},"Time-Restricted Eating (TRE)","TRE participants are instructed to eat two main meals and limit snacking from 12:00 to 20:00 daily, and to fast from 20:00 until 12:00 daily",[18],"Behavioral: Time-Restricted Eating",{"label":20,"type":6,"description":21,"interventionNames":22},"Control group","The control group will receive guidance on a quantitative reduction in total caloric intake by following a balanced diet, but no timing window for food intake will be prescribed to the participants in the control group.",[23],"Behavioral: Weight-loss counseling",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"BEHAVIORAL","Modified Alternate Day Fasting","Participants are instructed to fast every other day.",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Time-Restricted Eating","Participants are instructed to limit food intake to two main meals consumed in maximum 8 hours per day",[15],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Weight-loss counseling","Participants will receive nutrition counseling to structure their main meals according to the plate model for weight-loss and to reduce number of consumed plates.",[20],[40],{"name":41,"affiliation":5,"role":42},"Philipp Gerber, MD","PRINCIPAL_INVESTIGATOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":30,"email":48},"Leonie Mönch, MSc","CONTACT","+41 44 255 31 64","leonie.moench@usz.ch",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Department of Endocrinology, Diabetology and Clinical Nutrition","RECRUITING","Zurich","Canton of Zurich","8091","Switzerland",{"type":58,"coordinates":59},"Point",[60,61],8.55,47.36667,{"lat":61,"lon":60},[64,65,67],{"name":41,"role":46,"phone":30,"phoneExt":30,"email":30},{"name":66,"role":46,"phone":30,"phoneExt":30,"email":30},"Nina Derron, PhD",{"name":68,"role":46,"phone":30,"phoneExt":30,"email":30},"Johanna Zehnder, MSc",{"type":70,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100540979",false,"NCT06323889","Longitudinal Monitoring During Intermittent Fasting Protocols in Obese Adults","Longitudinal Monitoring During Different Intermittent Fasting Protocols in Obese Adults - a Randomized Clinical Trial","LIMITFOOD2","Inclusion Criteria:\n\n* Age between 18-50 years, both inclusive\n* Obese, BMI between 30 and 40 kg\u002Fm\\^2 (obesity grade I or II), both inclusive\n* Non-smoker\n* Good knowledge of German or English language\n* Stable weight change (change \\\u003C +\u002F- 3% current bodyweight) for 3 months prior to the study\n* HbA1c \\\u003C 6.5% without glucose lowering medication\n* LDL-cholesterol \\\u003C 4.6mmol\u002Fl without lipid lowering medication\n\nExclusion Criteria:\n\n* Participants who have a fasting period of \\> 12h per day on a regular basis and do not eat at least three main meals per day.\n* Current habitual use of dietary supplements (e.g., vitamins, minerals) and\u002For unwillingness to cease intake of dietary supplements.\n* Antibiotics intake during 3 months prior to the study due to possible interference with metabolic parameters\n* Food intolerances, allergies and sensitivities (severe food allergies) or dietary restrictions (e.g. vegan lifestyle)\n* Acute or chronic infections, malignant disease, renal, hepatic (more than two-fold increased transaminases), pulmonary, neurological (epilepsy) or psychiatric diseases, manifested atherosclerosis, or any other disease precluding participation in the study.\n* Diabetes\n* Known alcohol, substance or drug abuse, concomitant medication\n* More than four hours of physical exercise per week\n* Women who are pregnant, breast-feeding or aiming to become pregnant during course of the trial\n* Women and men on hormonal supplementation\n* Women with an irregular menstrual cycle according to the FIGO criteria\n* Therapy with antidepressants within the past 6 months\n* Regular therapy with acetylsalicyclic acid or current medication to regulate blood sugar, blood pressure or lipids\n* Participants likely to fail to comply with the study protocol\n* Participants who do not give informed consent",true,"ALL","18 Years","50 Years",{"count":83,"type":84},90,"ESTIMATED","INTERVENTIONAL",[87],"NA","LIMITFOOD2 is a randomized clinical intervention study that investigates the effects of two different intermittent fasting protocols compared to a control group on the health of obese adults. A total of 90 participants will be randomized into three equally sized groups: a modified alternate day fasting, a time-restricted eating and a control group, receiving general weight-loss counseling.",[90,91,92],"Intermittent Fasting","Obesity","Time Restricted Eating",[94,95,96,91,97],"Overnutrition","Nutrition Disorders","Body Weight","Longitudinal monitoring","2024-12-17",{"date":100,"type":101},"2024-12-20","ACTUAL",{"date":103,"type":101},"2024-09-23",{"date":105,"type":84},"2027-01",{"name":5,"class":6},1]