Loop Diuretic Therapy in Acutely Decompensated Heart Failure
ConditionAcute Heart Failure
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Siena
About this trial
DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF. Previous pilot study design was planned to anticipate a larger multicenter trial able to definitively evaluate the optimal loop diuretic use strategy in patients with ADHF.
Eligibility criteria
Qualifiers
Patients over 18 years;
Patients with diagnosis of ADHF(dyspnea, orthopnea, peripheral edema or major fatigue and at least two clinical signs including rales, hepatomegaly, pulmonary congestion on chest radiography, jugular vein dilatation, or a third heart sound);
Blood BNP > 100 pg/mL;
Disqualifiers
Patients who receive more than 40 mg of IV furosemide;
End-Stage renal disease or renal replacement therapy;
Recent myocardial infarction (within thirty days of screening);
Systolic blood pressure < 80 mmHg;
Trial design
Treatments tested in this trial
- Continuous Furosemide Infusion
- Intermittent Furosemide Infusion
Treatment groups
370 Participants
are divided into 2 treatment groupsLocations
4Ospedale Madonna della Navicella ChioggiaVenezia, Italy
Azienda Ospedaliera di Padova Padova Italy
University of Rome La Sapienza00189, Roma Italy
Department of Internal Medicine, Cardiovascular Diseases Unit53100, Siena Italy
Sponsors and collaborators
University of Siena
Lead sponsor
University of Roma La Sapienza
Collaborator
Ospedale Regina Montis Regalis
Collaborator
University of Naples
Collaborator
A.O.U. Città della Salute e della Scienza
Collaborator
University of Milan
Collaborator
Source ClinicalTrials.gov