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Città della Salute e della Scienza",{"name":116,"class":6},"University of Milan","100258043",false,"NCT02638142","Loop Diuretic Therapy in Acutely Decompensated Heart Failure","Continuous Versus Bolus Intermittent Loop Diuretic Infusion in Acutely Decompensated Heart Failure: Evaluation of Renal Function, Congestion Signs, BNP and Outcome","DIUR-AHF","Inclusion Criteria:\n\n* Patients over 18 years;\n* Patients with diagnosis of ADHF(dyspnea, orthopnea, peripheral edema or major fatigue and at least two clinical signs including rales, hepatomegaly, pulmonary congestion on chest radiography, jugular vein dilatation, or a third heart sound);\n* Blood BNP \\> 100 pg\u002FmL;\n\nADHF: Acute Decompensated Heart Failure; BNP: B-type Natriuretic Peptide; IV: IntraVenous; LVEF: Left Ventricular Ejection Fraction.\n\nExclusion Criteria:\n\n* Patients who receive more than 40 mg of IV furosemide;\n* End-Stage renal disease or renal replacement therapy;\n* Recent myocardial infarction (within thirty days of screening);\n* Systolic blood pressure \\\u003C 80 mmHg;\n* Creatinine levels \\> 4 mg\u002FdL;\n* Patients affected by sepsis, liver diseases, inflammatory diseases or neoplastic diseases.","ALL","18 Years",{"count":127,"type":128},370,"ESTIMATED","OBSERVATIONAL","DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF. Previous pilot study design was planned to anticipate a larger multicenter trial able to definitively evaluate the optimal loop diuretic use strategy in patients with ADHF.",[132],"Acute Heart Failure",[134,135,136,137,138],"loop diuretic","heart failure","renal dysfunction","congestion signs","BNP","2025-08-04",{"date":141,"type":142},"2025-08-08","ACTUAL",{"date":144,"type":142},"2015-12",{"date":146,"type":128},"2028-01",{"name":5,"class":6},4]