[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100475091":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":28,"studyPopulation":31,"armGroups":32,"interventions":51,"overallOfficials":57,"centralContacts":61,"locations":71,"responsibleParty":109,"collaborators":113,"id":116,"slug":28,"hasResults":117,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":123,"sex":124,"minAge":125,"maxAge":126,"enrollmentInfo":127,"targetDuration":28,"studyType":130,"phases":28,"briefSummary":131,"conditions":132,"keywords":134,"overallStatus":73,"whyStopped":28,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":147},{"fullName":5,"class":6},"China-Japan Friendship Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Lung function decline in Pre-COPD and Mild-COPD patients","FEV1 decline in Pre-COPD and Mild-COPD patients","2 years",[14,17],{"measure":15,"description":16,"timeFrame":12},"Lung function decline in smokers with Pre-COPD and Mild-COPD","FEV1 decline in smokers with Pre-COPD and Mild-COPD",{"measure":18,"description":19,"timeFrame":12},"Lung function decline in non-smokers with Pre-COPD and Mild-COPD","FEV1 decline in non-smokers with Pre-COPD and Mild-COPD",[21,24],{"measure":22,"description":23,"timeFrame":12},"Lung function decline and biomarkers in Pre-COPD and Mild-COPD patients","Association between FEV1 decline and biomarkers in blood, sputum or urine in Pre-COPD and Mild-COPD patients",{"measure":25,"description":26,"timeFrame":12},"Lung function decline and Image markers in Pre-COPD and Mild-COPD patients","Association between FEV1 decline and structural markers form chest CT scan in Pre-COPD and Mild-COPD patients",{"allocation":28,"interventionModel":28,"interventionModelDescription":28,"primaryPurpose":28,"observationalModel":29,"timePerspective":30,"maskingInfo":28},null,"COHORT","PROSPECTIVE","Volunteers with mild lung function abnormality will be included in this cohort study.",[33,38,42,45,48],{"label":34,"type":28,"description":35,"interventionNames":36},"Smokers with Pre-COPD","Smoking history ≥ 10 pack-years 0.7≤ FEV1\u002FFVC\\\u003C0.8 and FEV1%pred ≥ 80% (post-bronchodilator)",[37],"Behavioral: smoking",{"label":39,"type":28,"description":40,"interventionNames":41},"Smokers with Mild-COPD","Smoking history ≥ 10 pack-years FEV1\u002FFVC\\\u003C0.7 and FEV1%pred ≥ 80% (post-bronchodilator)",[37],{"label":43,"type":28,"description":44,"interventionNames":28},"Non-Smokers with Pre-COPD","Smoking history \\\u003C 10 pack-years or never-smokers 0.7≤ FEV1\u002FFVC\\\u003C0.8 and FEV1%pred ≥ 80% (post-bronchodilator)",{"label":46,"type":28,"description":47,"interventionNames":28},"Non-Smokers with Mild-COPD","Smoking history \\\u003C 10 pack-years or never-smokers FEV1\u002FFVC\\\u003C0.7 and FEV1%pred ≥ 80% (post-bronchodilator)",{"label":49,"type":28,"description":50,"interventionNames":28},"Healthy Controls","Healthy volunteers without smoking history FEV1\u002FFVC ≥ 0.8 and FEV1%pred ≥ 80% (post-bronchodilator)",[52],{"type":53,"name":54,"description":55,"armGroupLabels":56,"otherNames":28},"BEHAVIORAL","smoking","Smoking history and spirometry are used to define groups",[39,34],[58],{"name":59,"affiliation":5,"role":60},"Ting Yang, M.D.","PRINCIPAL_INVESTIGATOR",[62,67],{"name":63,"role":64,"phone":65,"phoneExt":28,"email":66},"Ke Huang, M.D.","CONTACT","+86-010-84206276","huangke_zryy@163.com",{"name":68,"role":64,"phone":69,"phoneExt":28,"email":70},"Jieping Lei, PhD","+86-010-84206279","jiepinglei@126.com",[72,93],{"facility":5,"status":73,"city":74,"state":75,"zip":76,"country":77,"countryCode":78,"cosmosGeoPoint":79,"geoPoint":84,"contacts":85},"RECRUITING","Beijing","Beijing Municipality","100029","China","CN",{"type":80,"coordinates":81},"Point",[82,83],116.39723,39.9075,{"lat":83,"lon":82},[86,89,91],{"name":87,"role":64,"phone":88,"phoneExt":28,"email":66},"Ke Huang, MD","+86-15120079197",{"name":87,"role":90,"phone":28,"phoneExt":28,"email":28},"SUB_INVESTIGATOR",{"name":92,"role":60,"phone":28,"phoneExt":28,"email":28},"Ting Yang, MD",{"facility":94,"status":73,"city":95,"state":96,"zip":97,"country":77,"countryCode":78,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Affiliated Hospital of Zunyi Medical University","Zunyi","Guizhou","563000",{"type":80,"coordinates":99},[100,101],106.90722,27.68667,{"lat":101,"lon":100},[104,108],{"name":105,"role":64,"phone":106,"phoneExt":28,"email":107},"Liang Zhou, MD","15208628481","syj_1991@163.com",{"name":105,"role":60,"phone":28,"phoneExt":28,"email":28},{"type":110,"investigatorFullName":111,"investigatorTitle":112,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"SPONSOR_INVESTIGATOR","Ting YANG","Vice Director of Respiratory Center",[114],{"name":115,"class":6},"Chinese Academy of Medical Sciences","100475091",false,"NCT05466396","Lung Health of Early COPD: A Multi-center Cohort Study","Lung Health of Early Chronic Obstructive Pulmonary Disease: A Multi-center Cohort Study","LHEC","Inclusion Criteria:\n\n1. Gender: male or female\n2. Age: 35-75 years old\n3. post-bronchodilator spirometry: FEV1\u002FFVC \\\u003C 0.8 and FEV1%pred ≥80%\n\nExclusion Criteria:\n\n1. Other diseases may affect lung function, like lung cancer, bronchiectasis, interstitial lung disease or chest surgery.\n2. BMI \\> 35 kg\u002Fm2\n3. Dementia or other severe neurological disease\n4. Pregnancy\n5. Conditions that contraindicated lung function test",true,"ALL","35 Years","75 Years",{"count":128,"type":129},1550,"ESTIMATED","OBSERVATIONAL","This is a multi-center, prospective, cohort study in early COPD patients. This study aims to elucidate the lung function decline and its association with smoking and other risk factors. Other biomarkers and image markers from chest CT scan are also analyzed to investigate the lung function in early COPD patients.",[133],"COPD",[135,136,137],"early COPD","spirometry","lung health","2025-02-13",{"date":140,"type":141},"2025-02-17","ACTUAL",{"date":143,"type":141},"2022-08-01",{"date":145,"type":129},"2027-12-31",{"name":111,"class":6},2]