[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622101":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":45,"collaborators":10,"id":47,"slug":10,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Peking Union Medical College Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Mechanically ventilated patients with hypoxemia requiring clinical PEEP optimization",null,"The study will enroll mechanically ventilated patients under sedation\u002Fanalgesia without spontaneous breathing, exhibiting a oxygenation index (PaO₂\u002FFiO₂ ratio) \\\u003C300 mmHg, and deemed clinically eligible for PEEP titration by attending physicians.",[13],"Diagnostic Test: The lung recruitment potential assessed and PEEP titration by ventilator and 2D\u002F3D EIT",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","The lung recruitment potential assessed and PEEP titration by ventilator and 2D\u002F3D EIT","The patient will undergo a standardized PEEP titration procedure and determination of the Recruitment-to-Inflation ratio (R\u002FI ratio), with concurrent monitoring by both 2D- and 3D- EIT.",[9],[21],{"name":22,"affiliation":5,"role":23},"Huaiwu He","STUDY_CHAIR",[25],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","010-6915-2300","tjmuhhw@126.com",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences","RECRUITING","Beijing","Beijing Municipality","100730","China",{"type":38,"coordinates":39},"Point",[40,41],116.39723,39.9075,{"lat":41,"lon":40},[44],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100622101",false,"NCT07379242","Lung Recruitment Assessed by 2D\u002F3D-EIT and R\u002FI Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation","Lung Recruitment Assessed by Two-Dimensional\u002FThree-Dimensional Electrical Impedance Tomography and Recruitment-to-Inflation Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation","Inclusion Criteria:\n\n* Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing.\n* Oxygenation index \\\u003C 300 mmHg.\n* Patients who are clinically judged by the attending doctor to require the PEEP titration.\n\nExclusion Criteria:\n\n* Aged under 18 years.\n* Pregnancy.\n* Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others).\n* No informed consent obtained.\n* Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor.\n* High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.","ALL","18 Years",{"count":56,"type":57},50,"ESTIMATED","OBSERVATIONAL","The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R\u002FI ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is:\n\nAre the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R\u002FI ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R\u002FI ratios measured at high and low PEEP levels.",[61],"Acute Respiratory Failure (ARF)",[63,64,65,66,67,68],"Acute respiratory failure","PEEP titration","3D-EIT","2D-EIT","Lung recruitability","R\u002FI ratio","2026-01-23",{"date":71,"type":72},"2026-01-30","ACTUAL",{"date":74,"type":72},"2025-09-01",{"date":76,"type":57},"2026-09-30",{"name":5,"class":6},1]