About this trial
To breakthrough the bottleneck identified, we will conduct a cross-sectional study to develop a symptom clustering model for depression and anxiety. A wide range of statistical methods as well as machine learning approaches were explored, and a cohesive hierarchical clustering algorithm will be used. After developing the model, a symptom-matched intervention program based on problem solving therapy will be formulated. We are supposed to examine whether its use for personalizing symptom-matched psychological treatment can lead to improved patient outcomes, compared with usual care. This project is expected to provide a new and precise method for the emotion management, which will provide a standardized intervention pathway combining screening with treatment for the management of depression symptom and anxiety symptom. A preciser intervention matched to individual symptoms may provide important insight in improving patient outcome as well as a standardized mood management pathway targeting to the early detection and intervention for community residents.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Aged between 18 and 64 years. PHQ-9 ≥10 and/or GAD-7 ≥8 at baseline assessment defined as the threshold for caseness.
Disqualifiers
They are receiving psychological therapy during an interview for any mental health issue;
currently acutely suicidal or have attempted suicide in the past 2 months, as indicated by PHQ-9 item 9;
cognitively impaired or diagnosed with bipolar disorder or psychosis or experiencing psychotic symptoms; d) dependent on alcohol or drugs; e) living with an unstable or acute medical illness that would interfere with trial participation.
Trial design
Parallel
Treatments tested in this trial
problem solving therapy
BehavioralProblem-solving therapy-based holistic emotion management interventions matched to individual symptoms
control group
Other interventionRoutine psychological care and guidance on mood management
Treatment groups
Trial outcomes
Primary outcomes
The Patient Health Questionnaire (PHQ-9)
GAD-7
Secondary outcomes
PSQI
WHODAS 2.0
EQ-5D-5L
Other outcomes
remission rate
PHQ-9 \< 5 AND/OR GAD-7 \< 5
SBQ-R
It was utilized to assess suicide ideation for exclusion
Sponsors and contacts
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Wuhan Mental Health Centre
Lead sponsor
National Natural Science Foundation of China
Collaborator