Machine Learning-based Classification of Symptom Clusters and Online CBT

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-64
SponsorWuhan Mental Health Centre

About this trial

To breakthrough the bottleneck identified, we will conduct a cross-sectional study to develop a symptom clustering model for depression and anxiety. A wide range of statistical methods as well as machine learning approaches were explored, and a cohesive hierarchical clustering algorithm will be used. After developing the model, a symptom-matched intervention program based on problem solving therapy will be formulated. We are supposed to examine whether its use for personalizing symptom-matched psychological treatment can lead to improved patient outcomes, compared with usual care. This project is expected to provide a new and precise method for the emotion management, which will provide a standardized intervention pathway combining screening with treatment for the management of depression symptom and anxiety symptom. A preciser intervention matched to individual symptoms may provide important insight in improving patient outcome as well as a standardized mood management pathway targeting to the early detection and intervention for community residents.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Aged between 18 and 64 years. PHQ-9 ≥10 and/or GAD-7 ≥8 at baseline assessment defined as the threshold for caseness.

Disqualifiers

They are receiving psychological therapy during an interview for any mental health issue;

currently acutely suicidal or have attempted suicide in the past 2 months, as indicated by PHQ-9 item 9;

cognitively impaired or diagnosed with bipolar disorder or psychosis or experiencing psychotic symptoms; d) dependent on alcohol or drugs; e) living with an unstable or acute medical illness that would interfere with trial participation.

Trial design

Design model

Parallel

Treatments tested in this trial

  • problem solving therapy

    Behavioral

    Problem-solving therapy-based holistic emotion management interventions matched to individual symptoms

  • control group

    Other intervention

    Routine psychological care and guidance on mood management

Treatment groups

380 Participants
are divided into 2 treatment groups
Group A: 8 weeks Problem-solving therapyExperimental treatment 1 intervention
Group B: treatment as usualPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

The Patient Health Questionnaire (PHQ-9)

Time frame
Baseline, week 1, week 2, week 3, week 4, week 5, week 6, week 7, week 8, week 12, week 20, week 32
2

GAD-7

Time frame
Baseline, week 1, week 2, week 3, week 4, week 5, week 6, week 7, week 8, week 12, week 20, week 32

Secondary outcomes

1

PSQI

Time frame
Baseline, week 1, week 4, week 6, week 8, week 12, week 20, week 32
2

WHODAS 2.0

Time frame
Baseline, week 1, week 4, week 6, week 8, week 12, week 20, week 32
3

EQ-5D-5L

Time frame
Baseline, week 1, week 4, week 6, week 8, week 12, week 20, week 32

Other outcomes

1

remission rate

PHQ-9 \< 5 AND/OR GAD-7 \< 5

Time frame
week 8, week 12, week 20, week 32
2

SBQ-R

It was utilized to assess suicide ideation for exclusion

Time frame
week -1 pre-screening

Sponsors and contacts

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Wuhan Mental Health Centre

Lead sponsor

National Natural Science Foundation of China

Collaborator