[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636659":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":37,"collaborators":41,"id":44,"slug":10,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":10,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":57,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":10,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Far Eastern Memorial Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"FEMHPregnancy cohort",null,"Throughout pregnancy, delivery, and infant follow-up at FEMH",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"CHI MAN KUOK","CONTACT","(+886) 952289592","carmentoe@hotmail.com",[19,32],{"facility":5,"status":20,"city":21,"state":10,"zip":10,"country":22,"cosmosGeoPoint":23,"geoPoint":28,"contacts":29},"NOT_YET_RECRUITING","New Taipei City","Taiwan",{"type":24,"coordinates":25},"Point",[26,27],121.45703,25.06199,{"lat":27,"lon":26},[30],{"name":5,"role":15,"phone":31,"phoneExt":10,"email":10},"+886 2 8966 7000",{"facility":5,"status":33,"city":21,"state":10,"zip":10,"country":22,"cosmosGeoPoint":34,"geoPoint":36,"contacts":10},"RECRUITING",{"type":24,"coordinates":35},[26,27],{"lat":27,"lon":26},{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Chi-Man Kuok","Neonatologist",[42],{"name":43,"class":6},"Fu Jen Catholic University","100636659",false,"NCT07568561","Maternal Methyl-Nutrient Status and Infant Neurodevelopment Study","Maternal Methyl-Nutrient Status During Pregnancy and Its Association With Infant Neurodevelopment: Exploring Potential Mechanisms","Inclusion Criteria for Pregnant Women\n\n* Aged 20-45 years\n* Singleton pregnancy\n* Receiving routine prenatal care at the study site and planning to deliver at Far Eastern Memorial Hospital\n\nExclusion Criteria for Pregnant Women\n\n* Diagnosed with major chronic diseases, including renal disease (defined as chronic kidney disease stage 3 or above or history of renal transplantation), liver disease (defined as liver cirrhosis or history of liver transplantation), or malignancy\n* Alcohol consumption during pregnancy\n* Diagnosed with eating disorders or psychiatric conditions that may impair the assessment of nutritional status\n\nInclusion Criteria for Newborns\n\n● Newborns delivered by mothers who participate in this study\n\nExclusion Criteria for Newborns\n\n* Diagnosed with congenital anomalies, epilepsy, or severe brain injury\n* Inability to complete neurodevelopmental assessments at 6 months, 1 year, and 2 years of age at the study site\n* Infants whose mothers are diagnosed with eating disorders or psychiatric conditions that may impair the assessment of nutritional status",true,"ALL","0 Days","45 Years",{"count":55,"type":56},240,"ESTIMATED","2 Years","OBSERVATIONAL","This prospective cohort study examines the relationship between maternal methyl-nutrient status during pregnancy and offspring neurodevelopment. It integrates maternal dietary, biomarker, genetic, and microbiome data and follows children up to 24 months.",[61,62,63,64,65,66,67,68,69],"Infant Neurodevelopment","Nutrition","Methylation","Birth Outcomes","Pregnancy","Dietary Quality","Dietary Intake Assessment","Homocysteine","Trimethylamine N-oxide (TMAO)","2026-05-27",{"date":72,"type":73},"2026-05-29","ACTUAL",{"date":70,"type":73},{"date":76,"type":56},"2029-01-18",{"name":5,"class":6},2]