[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577009":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":30,"responsibleParty":45,"collaborators":10,"id":47,"slug":10,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":69,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Centre Francois Baclesse","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Case group",null,"participant with a hereditary predisposition linked to a BRCA1\u002F2 mutation (case)",[13],"Genetic: Mutation Burden cfMB analysis",{"label":15,"type":10,"description":16,"interventionNames":17},"Control group","participant not carrying a hereditary predisposition linked to a BRCA1\u002F2 mutation (control) participant from the same sibling as the carrier participant (sister)",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"GENETIC","Mutation Burden cfMB analysis","Blood samples will be collected (one time only)",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Louise May THIBAUT, Medical Doctor","CONTACT","0231455050","lm.thibaut@baclesse.unicancer.fr",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":10,"country":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Centre François Baclesse","RECRUITING","Caen","France",{"type":37,"coordinates":38},"Point",[39,40],-0.35912,49.18585,{"lat":40,"lon":39},[43],{"name":44,"role":27,"phone":10,"phoneExt":10,"email":29},"Louise May THIBAUT, MD",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100577009",false,"NCT06792721","MEASUREMENT OF CIRCULATING MUTATION BURDEN","EVALUATION OF CANCER RISK BY MEASUREMENT OF CIRCULATING MUTATIONAL BURDEN IN CARRIERS OF A GENETIC PREDISPOSITION","cRISK","Inclusion Criteria:\n\n* Female participant\n* Participant undergoing oncogenetic follow-up at the Centre François Baclesse\n* Participant belonging to a pair of related biological siblings\n* Within the sibling pair, one participant is a carrier of a hereditary predisposition linked to a BRCA1\u002F2 mutation (case), and the other participant is not a carrier (control).\n* Participant between 30 and 50 years of age\n* Participant affiliated to a social security scheme\n* Participant having given her consent to participate by signing an informed consent form prior to any specific study-related procedure.\n\nExclusion Criteria:\n\n\\-",true,"FEMALE","30 Years","50 Years",{"count":59,"type":60},30,"ESTIMATED","OBSERVATIONAL","Cancer-free women with a hereditary predisposition to breast and\u002For ovarian cancer",[64,65,66,67,68],"Breast Carcinoma","Genetic Predisposition to Cancer","BRCA Mutation","cfMB","Mutation Burden",[67,70,71,72,73],"predisposition to cancer","BRCA1","BRCA2","breast cancer","2025-07-07",{"date":76,"type":77},"2025-07-08","ACTUAL",{"date":79,"type":77},"2025-07-04",{"date":81,"type":60},"2027-12-30",{"name":5,"class":6},1]